Sensitivity of levofloxacin in combination with ampicillin-sulbactam and tigecycline against multidrug-resistant Acinetobacter baumannii

Background and Objectives: The selection of alternative treatment options with antibiotic combinations may be used for successful managing of multidrug-resistant Acinetobacter baumannii. The aim of this study was to determine the synergistic effects of ampicillin-sulbactam combined with either levofloxacin or tigecycline against MDR A. baumannii. Materials and Methods: A total 124 of A.baumannii isolates collected from clinical samples of hospitalized patients which assessed for antibiotic susceptibility using disk diffusion method. E-test was used on 10 MDR A. baumannii isolates to determine the minimum inhibitory concentration (MIC) of ampicillin-sulbactam, levofloxacin and tigecycline. Any synergistic effects were evaluated at their own MIC using E-test assay at 37°C for 24 hours. Synergy was defined as a fractional inhibitory concentration index (FICI) of ≤0.5. Results: Levofloxacin plus ampicillin-sulbactam combination was found to have synergistic effects (FIC index: ≤0.5) in 90% of the isolates, but there was no synergistic effect for ampicillin-sulbactam/tigecycline and tigecycline/ levofloxacin combination. The antagonist effect in 50% of isolates (FIC index: >2) showed in combination of levofloxacin/tigecycline. Conclusion: The emergence of multidrug A. baumannii isolates requires evaluating by combination therapy. The combination of levofloxacin plus a bactericidal antibiotic such as ampicillin-sulbactam is recommended. Results should be confirmed by clinical studies. Keywords: Acinetobacter baumannii, Etest Methods, Microbial Drug Resistance, Synergistic effec

Electrochemical-Mechanistic Model for Concrete Cover Cracking Due to Corrosion Initiated by Chloride Diffusion

A holistic electrochemical-mechanistic model of the corrosion of steel reinforcing bars inside concrete that accounts for the diffusion of oxygen and moisture into the concrete and rust layers, the densification of rust due to confinement, the flow of rust into the concrete pores, the development of internal pressure due to rust buildup, and cracking of the concrete cover is presented. The relationship between the corrosion current and the pressure buildup due to the corrosion products for different concrete cover thicknesses and concrete quality was calibrated through experiments using an accelerated corrosion test with an applied current. Results from finite-element analysis with an inelastic smeared crack concrete model were used to calibrate a simple analytical model of the critical internal pressure required to cause cracking of the concrete cover. The various submodels are linked together to predict the time for cracking of the concrete cover from the time of corrosion initiation. Results of parametric studies using the model indicate that the main factors that control the corrosion current and the time to cracking are the boundary condition, water-cement ratio, and concrete cover

Antibiotic resistance pattern and distribution of Vietnamese extended-spectrum- β lactamase (VEB-1) gene in Acinetobacter baumannii isolated from hospitalized patients in Kashan Shahid Beheshti hospital during 2013-2014

Background: Acinetobacter baumannii are widely distributed pathogens in hospitals. They have the ability to have various mechanisms of resistance. Multiple drug resistant (MDR) strains of A. baumannii have created therapeutic problems worldwide. The aim of the present study was to determine the antimicrobial susceptibility and detection of blaOXA51 and VEB-1 genes of A. baumannii isolated from clinical specimens in teaching hospital. Materials and Methods: A descriptive cross-sectional study was performed on 124 A. baumannii strains isolated from patients in Beheshti hospital, Kashan, Iran, during 2013-2014. At the species level, the isolates were identified by conventional biochemical tests and then confirmed by the Microgen kit (GNA). An antibiotic susceptibility test was performed for 17 antimicrobial agents according to the CLSI guidelines. Multiple drug resistant was defined as presence of resistance to three or more classes of antibiotics. The presence of blaOXA51 and VEB-1 genes was investigated using the polymerase chain reation. Results: Acinetobacter baumannii isolates demonstrated the highest resistance to ceftriaxone, ceftazidime and cefotaxime. All isolates were sensitive to colistin and polymyxin. All isolates were positive for blaOXA51. Thirty-two isolates (25.8) were positive for the VEB-1 gene. Conclusion: This study highlights the high frequency of MDR isolates. The VEB-1 gene, which produces extended spectrum beta lactamase enzymes and inactivates third generation cephalosporins, was positive in more than 25 of the samples

Secure Simultaneous Information and Power Transfer for Downlink Multi-User Massive MIMO

In this article, downlink secure transmission in simultaneous information and power transfer (SWIPT) system enabled with massive multiple-input multiple-output (MIMO) is studied. A base station (BS) with a large number of antennas transmits energy and information signals to its intended users, but these signals are also received by an active eavesdropper. The users and eavesdropper employ a power splitting technique to simultaneously decode information and harvest energy. Massive MIMO helps the BS to focus energy to the users and prevent information leakage to the eavesdropper. The harvested energy by each user is employed for decoding information and transmitting uplink pilot signals for channel estimation. It is assumed that the active eavesdropper also harvests energy in the downlink and then contributes during the uplink training phase. Achievable secrecy rate is considered as the performance criterion and a closed-form lower bound for it is derived. To provide secure transmission, the achievable secrecy rate is then maximized through an optimization problem with constraints on the minimum harvested energy by the user and the maximum harvested energy by the eavesdropper. Numerical results show the effectiveness of using massive MIMO in providing physical layer security in SWIPT systems and also show that our closed-form expressions for the secrecy rate are accurate

Secure Simultaneous Information and Power Transfer for Downlink Multi-user Massive MIMO

In this paper, downlink secure transmission in simultaneous information and power transfer (SWIPT) system enabled with massive multiple-input multiple-output (MIMO) is studied. A base station (BS) with a large number of antennas transmits energy and information signals to its intended users, but these signals are also received by an active eavesdropper. The users and eavesdropper employ a power splitting technique to simultaneously decode information and harvest energy. Massive MIMO helps the BS to focus energy to the users and prevent information leakage to the eavesdropper. The harvested energy by each user is employed for decoding information and transmitting uplink pilot signals for channel estimation. It is assumed that the active eavesdropper also harvests energy in the downlink and then contributes during the uplink training phase. Achievable secrecy rate is considered as the performance criterion and a closed-form lower bound for it is derived. To provide secure transmission, the achievable secrecy rate is then maximized through an optimization problem with constraints on the minimum harvested energy by the user and the maximum harvested energy by the eavesdropper. Numerical results show the effectiveness of using massive MIMO in providing physical layer security in SWIPT systems and also show that our closed-form expressions for the secrecy rate are accurate

Quantum phases of dimerized and frustrated Heisenberg spin chains with s = 1/2, 1 and 3/2: an entanglement entropy and fidelity study

We study here different regions in phase diagrams of the spin-1/2, spin-1 and spin-3/2 one dimensional antiferromagnetic Heisenberg systems with frustration (next-nearest-neighbor interaction $J_2$) and dimerization ($\delta$). In particular, we analyze the behaviors of the bipartite entanglement entropy and fidelity at the gapless to gapped phase transitions and across the lines separating different phases in the $J_2-\delta$ plane. All the calculations in this work are based on numerical exact diagonalizations of finite systems.Comment: 12 pages, 15 figures; provided some finite size analysis results, some changes in text accordingly; to appear in J. Phys.: Condens. Matte