Fused core-modified meso-aryl expanded porphyrins

The synthesis and characterization of the first examples of singly and doubly fused expanded porphyrins containing dithienothiophene (DTT) cores are reported

Bio-efficacy of ground plant powders on the population of Tribolium castaneum (Herbst) in stored green gram

Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) is one of the major insect pests of stored grains. Experiment was conducted for studying the efficiency of ground plant materials for management of T. castaneum in stored green gram and effect of plant powders on seed germination in laboratory of Department of Entomology, CoA, CAU, Imphal during the period 2021-2022. Studies on effect of plant powders on management of T. castaneum revealed that Black pepper @ 1.5g/kg seed shows maximum mean adult mortality of 100.00 per cent and Sweet flag @ 1.5g/kg seed shows lowest mean adult mortality of 33.33 per cent. Highest seed damage was recorded in Sweet flag @ 1.5g/kg seed (8.00 per cent) and least was in Black pepper @ 1.5g/kg seed (1.67 per cent). Maximum adult emergence was noted in treatment of Sweet flag @ 1.5g/kg seed (8.00 per cent) and lowest was in China berry @ 1.5g/kg seed (1.33 per cent). Evaluation of germination percentage reveals that minimum germination percentage was recorded in Black pepper @ 1.5g/kg seed (91.33 per cent) and maximum was in Indian wormwood @ 1.5g/kg seed (98.67 per cent) but none of the treatment recorded the percentage below the prescribed germination percentage of green gram. Plant powders offers efficient control of red flour beetle and these are available locally and did not show any adverse on the environment and hence can be recommended as alternatives to the chemical insecticides

Indian commentary on the 2009 KDIGO clinical practice guideline for the diagnosis, evaluation, and treatment of chronic kidney disease-mineral and bone disorders

This commentary presents the view of an Expert Group of Indian nephrologists on adaptation and implementation of the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for evaluation and management of mineral and bone disorder in chronic kidney disease (CKD-MBD) for practice in India. Zonal meetings of nephrologists drawn from the cross-section were convened to discuss the KDIGO guidelines. Recommendations were presented in a central meeting of zonal representatives. The finalized recommendations were reviewed by all the participants. There was a broad agreement on most of the recommendations made by the KDIGO workgroup. Significant departures in the current guidelines from the previous Kidney Disease Outcome Quality Initiative (KDOQI) guidelines were also noted. The participants agreed that the available evidence did not allow more precise recommendations, and the recommended best practice suggestions were often based on relatively weak evidence. There is a remarkable lack of data from Indian patients. We comment on specific areas and amplify certain concepts where we feel that further guidance that goes beyond what is stated in the document might help Indian nephrologists in appropriate implementation of the KDIGO guidelines. This commentary is intended to help define practically implementable best practices based on current disease concepts and available research evidence, thereby positively affecting the quality of management of CKD-MBD in India, and eventually improving patient outcomes

Bio-efficacy of ground plant powders on the population of Tribolium castaneum (Herbst) in stored green gram

Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) is one of the major insect pests of stored grains. Experiment was conducted for studying the efficiency of ground plant materials for management of T. castaneum in stored green gram and effect of plant powders on seed germination in laboratory of Department of Entomology, CoA, CAU, Imphal during the period 2021-2022. Studies on effect of plant powders on management of T. castaneum revealed that Black pepper @ 1.5g/kg seed shows maximum mean adult mortality of 100.00 per cent and Sweet flag @ 1.5g/kg seed shows lowest mean adult mortality of 33.33 per cent. Highest seed damage was recorded in Sweet flag @ 1.5g/kg seed (8.00 per cent) and least was in Black pepper @ 1.5g/kg seed (1.67 per cent). Maximum adult emergence was noted in treatment of Sweet flag @ 1.5g/kg seed (8.00 per cent) and lowest was in China berry @ 1.5g/kg seed (1.33 per cent). Evaluation of germination percentage reveals that minimum germination percentage was recorded in Black pepper @ 1.5g/kg seed (91.33 per cent) and maximum was in Indian wormwood @ 1.5g/kg seed (98.67 per cent) but none of the treatment recorded the percentage below the prescribed germination percentage of green gram. Plant powders offers efficient control of red flour beetle and these are available locally and did not show any adverse on the environment and hence can be recommended as alternatives to the chemical insecticides

SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart.

Extracellular vesicles (EVs) mediate intercellular signaling by transferring their cargo to recipient cells, but the functional consequences of signaling are not fully appreciated. RBC-derived EVs are abundant in circulation and have been implicated in regulating immune responses. Here, we use a transgenic mouse model for fluorescence-based mapping of RBC-EV recipient cells to assess the role of this intercellular signaling mechanism in heart disease. Using fluorescent-based mapping, we detected an increase in RBC-EV-targeted cardiomyocytes in a murine model of ischemic heart failure. Single cell nuclear RNA sequencing of the heart revealed a complex landscape of cardiac cells targeted by RBC-EVs, with enrichment of genes implicated in cell proliferation and stress signaling pathways compared with non-targeted cells. Correspondingly, cardiomyocytes targeted by RBC-EVs more frequently express cellular markers of DNA synthesis, suggesting the functional significance of EV-mediated signaling. In conclusion, our mouse model for mapping of EV-recipient cells reveals a complex cellular network of RBC-EV-mediated intercellular communication in ischemic heart failure and suggests a functional role for this mode of intercellular signaling