Wynik w skali CHA2DS2-VASc jako czynnik predykcyjny nefropatii pokontrastowej u chorych z zawałem serca z uniesieniem odcinka ST poddanych pierwotnej interwencji wieńcowej

Background and aim: We aimed to investigate the predictive value of the CHA2DS2-VASc score in the development of contrast-induced nephropathy (CIN). Methods: A total of 2972 patients who had been diagnosed with ST elevation myocardial infarction (STEMI) and who had undergone primary coronary angioplasty were included in the study. The patients were divided into three groups according to the CHA2DS2-VASc score, i.e.: low risk (1 point), intermediate risk (2 points), and high risk (≥ 3 points). The groups were followed with regard to CIN development. Results: The median CHA2DS2-VASc score was significantly higher in the CIN(+) group compared to the CIN(–) group (3 vs. 2, p 1 (OR 4.25, 95% CI 3.10–5.82, p < 0.001) were found to be independent predictors for CIN development. Conclusions: The CHA2DS2-VASc score is an independent and strong predictor of CIN development in patients with acute STEMI.Wstęp: Badanie przeprowadzono w celu oceny wartości predykcyjnej skali CHA2DS2-VASc w odniesieniu do ryzyka rozwoju nefropatii pokontrastowej (CIN). Metody: Do badania włączono 2972 chorych, u których zdiagnozowano zawał serca z uniesieniem odcinka ST (STEMI) i wykonano pierwotną angioplastykę wieńcową. Uczestników badania podzielono na trzy grupy w zależności od wyniku w skali CHA2DS2-VASc: grupa niskiego ryzyka (1 punkt), grupa pośredniego ryzyka (2 punkty) i grupa wysokiego ryzyka (≥ 3 punkty). Wszystkie grupy obserwowano pod kątem rozwoju CIN. Wyniki: Mediana wyników w skali CHA2DS2-VASc była istotnie wyższa w grupie CIN(+) niż w grupie CIN(–) (3 vs. 2; p 1 (OR 4,25; p < 0,001) były niezależnymi czynnikami predykcyjnymi rozwoju CIN. Wnioski: Wynik w skali CHA2DS2-VASc jest silnym i niezależnym czynnikiem predykcyjnym rozwoju CIN u chorych z ostrym STEMI

The use of SSRI (Selective Serotonin Reuptake Inhibitors) in kleptomania’s treatment: case reports

Kleptomania is characterized by a recurrent failure to resist the impulse to steal objects not necessary for personal use or their monetary value. Although kleptomania has been identified for decades, very little is known about the reason, prevalence, and treatment of this disorder. Current knowledge about kleptomania is generally derived from case reports and theoretical studies on etiology. With regard to comorbidity, kleptomania is related to the obsessive compulsive disorder spectrum and to the broader spectrum of affective disorders. Accordingly, a psychopharmacological intervention with antidepressant drugs or mood stabilizers may be possible, even though there have been known results from controlled therapy studies to date. Nevertheless, the successful administration of such medication has been reported in several cases. Assuming a disturbed central serotonin reuptake, the use of selective serotonin reuptake inhibitors (SSRI) seems to be indicated. Consequently, in our study three outpatients who have diagnosed kleptomania by taking SSRI treatment is presented

Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction?

Introduction The correlation between erectile dysfunction (ED) and coronary artery disease has been emphasized and ED has been recognized as a potential independent risk factor and/or predictor of coronary artery disease (CAD). We evaluated the association between the number of occluded coronary arteries in myocardial infarction (MI) patients with the severity of ED, and investigated the influence of related risk factors in our study group. Materials and Methods 183 male patients who underwent coronary angiography because of acute MI from November 2009 to May 2011 were included. Following the stabilization of patients after the treatment, each patient was evaluated for erectile functionality. Risk factors such as age, diabetes, smoking, waist circumference, hypertension, and hematologic parameters were recorded. Results Among 183 patients with a mean age of 55.2 years who underwent coronary angiography due to acute MI, 100 (54.64%) had ED, while the ED rate was 45.36% (44/97) in cases of single-vessel disease, 64.5% (31/48) in cases of two-vessel disease, and 65.7% (25/38) in cases of three-vessel disease. The mean IIEF score was 24.2 &#177; 4.3, 20.4 &#177; 4.9 and 20.5 &#177; 4.2 for single or two or three-vessel disease, respectively. The presence of hypertension aggravated ED only in patients with three-vessel disease and increased total and LDL cholesterol levels in patients with single-vessel or two-vessel disease were accompanied by significantly decreasing IIEF scores. Conclusion The severity of ED correlated with the number of occluded vessels documented by coronary angiography, in male patients with acute myocardial infarction. In addition, the presence of hypertension had a significant influence over erectile function only in patients with three-vessel occlusion

The Effects of Personal Disease Management on Insufficiency Levels and Quality of Life in Patients with Arthritis

WOS: 000283186700017Objective: The aim of this study was to investigate the effects of personal education on insufficiency levels and quality in of the patients with inflammatory and non-inflammatory arthritis, and to investigate whether its effect was similar in these two different disease models. Material and Methods: Female patients admitted to our out-patient rheumatology clinic in an university hospital and diagnosed with gonarthrosis (N=30) and rheumatoid arthritis (N=30) were included in this semi-experimental study conducted between September 2007-June 2008. A private questionnaire was applied to each patient to collect their socio-demographic and disease-related data, and each patient was given information about the characteristics, causes and treatments of the disease. Moreover, the importance of adaptation to the medical treatment, diet and regular exercise, and also ways to cope with the disease were told to each patient. Before and, two and six weeks after the education period, insufficiency levels and quality of life of the patients were investigated by applying a health assessment questionnaire (HAQ) and SF-36 quality of life assessment form. Data were analyzed by numbers, percentages, Student-t test, repeated measures of One-way ANOVA and repeated measures of Two-way ANOVA (SPSS 15.0). Results: There were no significant differences between HAQ and SF-36 data in two arthritis groups before education. However, HAQdata were significantly improved in both two arthritis groups after education (p<0.05). In addition, all parameters in gonarthrosis group, and all parameters except social function in rheumatoid arthritis group were significantly improved for SF-36 data after education (p<0.05). No group differences were found for improved parameters. Conclusion: Our present data shows that patient education decreases the insufficiency levels in disease and increases the quality of life of the patients with gonarthrosis and rheumatoid arthritis

Evaluation of oxidative stress factors in patients with osteoporosis

Osteoporosis is an important disease with an increasing incidence that leads to serious losses in physical function and adversely affecting the life quality of women especially in postmenopausal period. Age, genetic structure, vitamin D and K abnormalities, estrogen deficiency, chronic inflammation and oxidative stress are considered among the most important risk factors for osteoporosis. Therefore, we aimed to investigate the plasma paraoxonase (PON1) activity, high-density lipoprotein (HDL), total sialic acid (TSA) and total oxidant/antioxidant status (TOS/TAS) of patients with osteoporosis in this study. Comparisons of 25 female patients diagnosed with osteoporosis aged between 51-67 and 10 healthy women between the ages ranged 50-68 were made in this study. PON1 activity, HDL, TSA, TOS and TAS levels were measured by spectrophotometrical method in plasma samples that obtained from blood samples of patients and healthy individuals. Results were expressed as mean ± standard deviation. Plasma PON1 activity, TAS and HDL levels were significantly lower in patiens with osteoporosis than the healty group (p [Med-Science 2017; 6(3.000): 479-82