Current induced magnetization dynamics in current perpendicular to the plane spin valves

We observe magnetization dynamics induced by spin momentum transfer in the noise spectra of current perpendicular to the plane giant magnetoresistance spin valves. The dynamics are observable only for those combinations of current direction and magnetic configuration in which spin transfer acts to reorient the free layer magnetization away from the direction set by the net magnetic field. Detailed measurements as a function of magnetic configuration reveal an evolution of the noise spectra, going from a spectrum with a well-defined noise peak when the free layer is roughly collinear with the pinned layer to a spectrum dominated by 1/f noise when the free layer is in an orthogonal configuration. Finally, the amplitude of the corresponding resistance noise increases rapidly with increasing current until it saturates at a value that is a substantial fraction of the magnetoresistance between parallel and antiparallel states.Comment: 21 pages, 7 figures, minor revisions in response to Phys. Rev. B referee

A quantitative systems pharmacology consortium approach to managing immunogenicity of therapeutic proteins

Immunogenicity is a major challenge in drug development and patient care. Currently, most efforts are dedicated to the elimination of the unwanted immune responses through T‐cell epitope prediction and protein engineering. However, because it is unlikely that this approach will lead to complete eradication of immunogenicity, we propose that quantitative systems pharmacology models should be developed to predict and manage immunogenicity. The potential impact of such a mechanistic model‐based approach is precedented by applications of physiologically‐based pharmacokinetics

Intramural diverticulosis of esophagus

A description is given of the etiology and pathology of intramural esophageal diverticulosis as so far discussed in the literature. In view of the course and the clinical findings in two young patients in whom this diagnosis was established, it is suggested that intramural diverticulosis develops as a result of a developmental disorder in the autonomic nervous system