Methylenetetrahydrofolate Reductase Gene Polymorphisms in Children with Attention Deficit Hyperactivity Disorder

<p><b>Objective</b>: The purpose of this study was to evaluate the relationship between 5,10- methylenetetrahydrofolate reductase (MTHFR) polymorphisms and Attention Deficit Hyperactivity Disorder (ADHD) in a sample of Turkish children.</p><p><b>Study Design:</b> MTHFR gene polymorphisms were assessed in 40 patients with ADHD and 30 healty controls. Two mutations in the MTHFR gene were investigated using polymerase chain reactions and restriction fragment length polymorphisms.</p><p><b>Results</b>: Although there were no statistically significant differences in genotype distributions of the C677T alleles between the ADHD and the control groups (p=0,678) but the genotypic pattern of the distributions of the A1298C alleles was different between the ADHD patients and the controls (p=0,033).</p><p><b>Conclusions: </b>Preliminary data imply a possible relationship between A1298C MTHFR polymorphisms and the ADHD.</p

Morning Glory Syndrome and Autism: A Case Report

Autism is a developmental neuropsychiatric disorder that starts in early years of life, lasts lifelong, and characterized by the triad of impaired social skills, delayed speech, and repetitive or unusual behaviours. Morning glory syndrome (MGS) is a congenital anomaly of the optic disc, first described in 1970 and named by Kindler due to a resemblance to the flower of the same name. Congenital anomalies are more common in autistics compared to normal population. Among all types of congenital anomalies, the frequency of autism is higher with brain and/or eye anomalies. In this paper, we reported a 2-year-old female, who was diagnosed to have morning glory syndrome when she was 14-months old and admitted to our clinic because of delayed speech and lack of communication. Although congenital eye anomalies and autism comorbidity is high, there is only one case diagnosed to have MGS with autism reported in the literature. We aimed to report this case because of the difference in visual impairment than previous case and to impress on the relationship between MGS and autism, which stems from the early development phase of embryological life, when there is increased sensitivity for genetic and environmental factors

Osteogenesis imperfecta and attention deficit hyperactivity disorder: A rare combination

Osteogenesis Imperfecta (OI) is a rare, autosomally inherited disorder of the connective tissue matrix that is characterized by bone fractures, deafness, and blue sclera. The impairment of Type 1 collagen production causes frequent fractures and increased bone fragility as well as reduced bone mass. Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurobehavioral disorder developed during childhood that is characterized by inattention, hyperactivity, impulsivity and, consequently, high risk for unintentional injury. This study will examine the case of a 6-year-old male admitted to the researchers clinic who has been diagnosed with OI and ADHD and has experienced reccurent traumatic injury. While in the clinic, the patient also expressed symptoms of anxiety such as insomnia, restlessness and irritability. This case has beenpresented since associations of both d,sorder is rare. Aside from the fact that these disorders are injury-related and, thus, require additional attention by clinicians, the simultaneous nature of these diseases is also important in that their interaction may provide opportunity for early diagnosis and necessary intervention. [Med-Science 2018; 7(1.000): 232-234

EXPERIMENTAL INVESTIGATION OF FLOW CHARACTERISTICS OF DISCRETIZED TRIANGULAR HYDROGRAPHS

36th IAHR World Congress -- JUN 28-JUL 03, 2015 -- Delft, NETHERLANDSWOS: 000398996204112In this study effect of discretization of triangular hydrographs on flow characteristics is investigated. All experimental tests are carried out in a rectangular flume of 70 cm width and 18 m length and having a slope of 0.004. The flow rate is measured by an electromagnetic flow meter mounted on the inlet pipe and the time variation of flow depth is monitored at various locations. The point velocities are measured by a side-looking ultrasonic velocity meter at 17 different elevations along the water column by repeating the same hydrograph 17 times in unsteady flows, so that the velocity time series could be obtained at each location. A pump speed control unit (PSCU) is used to generate the hydrograph. The results of a three step discretized hydrograph and a continuous triangular shaped hydrograph generated in the flume are compared. Rising and falling periods of both hydrographs are 5.5 minutes and the base and peak flow rates are 14 l/s and 62 l/s respectively. The time varying mean of velocity time series in both stream-wise and vertical directions are investigated. The velocity profiles as well as the turbulence characteristics are compared with the ones obtained from the triangular hydrograph and the discretized hydrograph at unsteady flow conditions. The effect of discretization of the triangular hydrograph on flow velocities and turbulence characteristics is also discussed.Int Assoc Hydro Environm Engn & Res, Boskalis, Van Oord, UNESCO IHE, Delft Univ Technol, Deltares, Minist Infrastructure & Environm, Rijkswaterstaat, Royal HaskoningDHV, ARCADIS, WItteveen Bos, AANDERAA, Prince Sultan Bin Abulaziz Int Prize Wate

Evaluation of the Interaction of Cinacalcet with Calf Thymus dsDNA: Use of Electrochemical, Spectrofluorimetric, and Molecular Docking Methods

The binding of drugs to DNA plays a critical role in new drug discovery and is important for designing better drugs. In this study, the interaction and binding mode of calf-thymus double-stranded deoxyribonucleic acid (ct-dsDNA) with cinacalcet (CIN) from the calcimimetic drug that mimics the action of calcium on tissues group were investigated. The interaction of CIN with ct-dsDNA was observed by the differential pulse voltammetry (DPV) technique by following the decrease in electrochemical oxidation signals to deoxyguanosine and adenosine. A competitive study was performed on an indicator, methylene blue, to investigate the interaction of the drug with ct-dsDNA by fluorescence spectroscopy. Interaction studies have shown that the binding mode for the interaction of CIN with ct-dsDNA could be groove-binding. According to the results obtained, the binding constant values were found to be 6.30 × 104 M−1 and 3.16 × 105 M−1, respectively, at 25 °C as obtained from the cyclic voltammetry (CV) and spectroscopic techniques. Possible molecular interactions of CIN with dsDNA were explored via molecular docking experiments. The docked structure indicated that CIN could fit well into the minor groove of the DNA through H-bonding and π-π stacking contact with CIN