39 research outputs found
The Cardiopulmonary Effects of the Calcitonin Gene-related Peptide Family
Cardiopulmonary diseases are very common among the population. They are
high -cost diseases and there are still no definitive treatments. The
roles of members of the calcitonin-gene related -peptide (CGRP) family
in treating cardiopulmonary diseases have been studied for many years
and promising results obtained. Especially in recent years, two
important members of the family, adrenomedullin and
adrenomedullin2/intermedin, have been considered new treatment targets
in cardiopulmonary diseases. In this review, the roles of CGRP family
members in cardiopulmonary diseases are investigated based on the
studies performed to date
Glutamine administration enhances the healing of lung parenchymal injuries and reduces air leakage in rats
Beneficial effects of glutamine on wound healing are well known. Parenchymal injuries in the lung cause air leakage that resolves with wound healing. We aimed to determine the effect of glutamine on the healing of lung injuries. Wistar albino female rats were randomized in three groups. One group (control, n = 7) received intraperitoneal injection of 0.9% sodium chloride (1.5 ml/day), while other group (GLN, n = 7) received glutamine (1.5 g/kg/day), beginning two days prior to the operation for total four days. After thoracotomy, a lung parenchymal lesion was made with a scalpel in the right upper lobe. Only thoracotomy was performed to sham group (n = 4). Air leakage was observed in the isolated lungs of control group, but not GLN and sham groups, at 5 cm H2O of positive airway pressure (p < 0.001). The threshold of positive airway pressure for air leakage was 4.85 +/- 0.37 and 19.42 +/- 4.54 cm H2O for control and GLN groups, respectively (p < 0.001). For measurement of collagen content in the healing parenchyma, digital images were processed to calculate the stained area percentage (SAP). SAP for immature collagen, a marker for wound healing, was 0.36 +/- 0.18% and 1.48 +/- 0.83% (p = 0.02) in control and GLN groups, respectively, but no significant difference was noted in SAP for mature collagen. The grade of inflammation was not significantly different between control and GLN groups. We conclude that glutamine enhances lung parenchymal healing by increasing immature collagen secretion
Minimal invaziv teknik uygulanan pektus ekskavatumlu olgularda erken dönem memnuniyet bildirimi
sıçanlardaalveolar hava kaçağı ve akciğer parankim iyileşmesinde sistemik glutaminin etkileri
Chest-wall metastasis in a patient who underwent liver transplantation due to hepatocellular carcinoma
Hepatocellular carcinoma is a common malignancy. It may cause extrahepatic metastases through haematogenous or lymphatic dissemination or direct invasion. Furthermore, methods such as fine-needle aspiration biopsies performed to obtain a diagnosis or percutaneous ethanol injection and radiofrequency hyperthermia performed for treatment may also cause tumour dissemination