Role of Process Alignment and End User Participation in Successful Implementation of E-Government Programs: Perspective of Different Stakeholders

In recent years, a number of developing countries have launched e-government programs, and several development agencies and governments have identified e-government implementation as a key policy priority. Driven by the success of a few projects in improving delivery of services to citizens and businesses, an increasing number of governments are making ICT investments in the public sector. Alignment of departmental processes in government and active participation of employee of government departments as well of participation and cooperation of government department’s users play vital role of success in such programs. Therefore, the major objective of the paper is to understand the role of process alignment and end user participation in success of e-government programs from the important stakeholders perspective; leaders, government departments as users, nodal IT agencies, and IT vendor organization. The research findings are based on survey carried out with 152 stakeholders in all categories through a questionnaire targeted in northern states in India

Role of Key Stakeholders in Successful E-Governance Programs: Conceptual Framework

In recent years, a number of developing countries have launched e-government programs, and several development agencies and governments have identified e-government implementation as a key policy priority. Driven by the success of a few projects in improving delivery of services to citizens and businesses, an increasing number of governments are making ICT investments in the public sector. While there has been a lot of success in these endeavors, evidence of failed projects has drawn attention to the level of risk involved in implementation. The study on role of different stakeholders is important to understand the improvements which can be made on these critical success factors. Hence the objective of this paper is to (1) To understand the role of key stakeholders which influence the success of e-governance projects. (2) Come up with a framework considering role of all these key stakeholders. Through a conceptual analysis the we tried to examine the relationship and role among different stakeholders and how they contribute towards successful implementation of e-governance programs

Acute Coronary Syndrome in a Young Patient with Dual Mechanical Valves and Therapeutic International Normalized Ratio - A Rare Occurrence

Patients of valvular heart disease treated with mechanical valve replacement are required to be on lifelong medication with anticoagulants. Complications may arise when adequate International Normalized Ratio (INR) control is not maintained, leading to thromboembolic events, but very few cases have been reported where these complications arise despite therapeutic INR control. We, here, highlight a case of rare fatal complication of Acute Coronary Syndrome in a one month postoperative patient of Dual Mechanical Valve Replacement with therapeutic INR, which evaded correct diagnosis due to unawareness on the part of the treating team of physicians

A rare case of long-term graft complication in a patient of middle aortic syndrome

Middle aortic syndrome (MAS) is rare entity described as a progressive narrowing of the aorta between the aortic arch and terminal bifurcation of the aorta. Surgical treatment is with the use of grafts for bypassing the narrow aortic segment. Rarely, graft complications may occur over long periods of time due to the axial growth of the patient and loss of tensile strength of the graft material. This is a case of MAS, presenting 34 years after initial surgery due to aneurysmal dilation of the graft, treated with redo surgery and complete recovery of the patient

Primitive neuroectodermal tumor with inferior vena cava thrombus: A rare case report

Primitive neuroectodermal tumors (PNETs) are rare type of small cell, aggressive tumors, commonly seen in the central nervoussystem, and PNET of the kidney with inferior vena cava thrombus is an extremely uncommon presentation of this entity. There are noestablished distinctive signs or radiological characteristics for diagnosis, but a majority of cases report positivity for CD99 marker.The patients usually present in the advanced stages of the disease and require progressive techniques of immunohistochemicalanalysis and expertise of multidisciplinary team of physicians to arrive at a correct diagnosis and have a proper management.Although rare, these tumors should be considered in the differential diagnosis of all patients with large renal masses, especially inthe younger population. We present a case of a 23-years-old female, with PNET of the left kidney, treated with radical nephrectomyand adjuvant chemotherapy

Cytological spectrum of granulomatous mastitis: diagnostic and treatment challenges

Background: Granulomatous mastitis (GM) is an inflammatory disease of the breast which clinico- radiologically mimics both inflammatory and malignant lesions. This leads to diagnostic dilemmas and delay in treatment. The aim of the present study was to review the cases diagnosed as granulomatous mastitis on Fine Needle Aspiration Cytology (FNAC) with an objective to co-relate their clinico-radiological findings, histology review where available and follow up treatment received to establish etiology and study the treatment outcome.Methods: Cytologically diagnosed cases of granulomatous mastitis were retrieved and reviewed from August 2015 - July 2017 records. Clinico-radiological co-relation, histology review where available and follow up treatment records were sought for.Results: Around 31.7% (530/1670) cases were reported as malignant, 60.3% (1009/1670) as benign proliferative and 7.9% (131/1670) as inflammatory lesions by breast FNA. 3.1% (51/1670) cases were reported as GM of all breast FNAC and 38% (51/131) of all inflammatory lesions. Follow up was available for 47 cases. Of which 26 (55.3%) cases were diagnosed as Tubercular Granulomatous mastitis (TGM) and 21(44.7%) were idiopathic granulomatous mastitis (IGM).Conclusions: Countries where tuberculosis is endemic, high degree of clinical suspicion and detailed work-up to rule out TGM is essential for all cases of granulomatous mastitis. Authors recommend a multidisciplinary workup with microbiological culture and molecular based tests on FNA material. This retrospective study illustrates that the cause of GM needs to be determined accurately for timely treatment, to avoid unnecessary delays and treatment dilemma in these patients

NetPath: a public resource of curated signal transduction pathways

NetPath, a novel community resource of curated human signaling pathways is presented and its utility demonstrated using immune signaling data

Evaluation of Critical Quality Attributes of a Pentavalent (A, C, Y, W, X) Meningococcal Conjugate Vaccine for Global Use

Towards achieving the goal of eliminating epidemic outbreaks of meningococcal disease in the African meningitis belt, a pentavalent glycoconjugate vaccine (NmCV-5) has been developed to protect against Neisseria meningitidis serogroups A, C, Y, W and X. MenA and X polysaccharides are conjugated to tetanus toxoid (TT) while MenC, Y and W polysaccharides are conjugated to recombinant cross reactive material 197 (rCRM197), a non-toxic genetic variant of diphtheria toxin. This study describes quality control testing performed by the manufacturer, Serum Institute of India Private Limited (SIIPL), and the independent control laboratory of the U.K. (NIBSC) on seven clinical lots of the vaccine to ensure its potency, purity, safety and consistency of its manufacturing. In addition to monitoring upstream-manufactured components, samples of drug substance, final drug product and stability samples were evaluated. This paper focuses on the comparison of the vaccine’s critical quality attributes and reviews key indicators of its stability and immunogenicity. Comparable results were obtained by the two laboratories demonstrating sufficient levels of polysaccharide O-acetylation, consistency in size of the bulk conjugate molecules, integrity of the conjugated saccharides in the drug substance and drug product, and acceptable endotoxin content in the final drug product. The freeze-dried vaccine in 5-dose vials was stable based on molecular sizing and free saccharide assays. Lot-to-lot manufacturing consistency was also demonstrated in preclinical studies for polysaccharide-specific IgG and complement-dependent serum bactericidal activity for each serogroup. This study demonstrates the high quality and stability of NmCV-5, which is now undergoing Phase 3 clinical trials in Africa and India