An Economic analysis of the potential for precision farming in UK cereal production

The results from alternative spatial nitrogen application studies are analysed in economic terms and compared to the costs of precision farming hardware, software and other services for cereal crops in the UK. At current prices, the benefits of variable rate application of nitrogen exceed the returns from a uniform application by an average of £22 ha−1 The cost of the precision farming systems range from £5 to £18 ha−1 depending upon the system chosen for an area of 250 ha. The benefits outweigh the associated costs for cereal farms in excess of 80 ha for the lowest price system to 200–300 ha for the more sophisticated systems. The scale of benefits obtained depends upon the magnitude of the response to the treatment and the proportion of the field that will respond. To be cost effective, a farmed area of 250 ha of cereals, where 30% of the area will respond to variable treatment, requires an increase in crop yield in the responsive areas of between 0·25 and 1.00 t ha−1 (at £65 t−1) for the basic and most expensive precision farming systems, respectively

Deprojection of luminosity functions of galaxies in the Coma cluster

We use a simple analytic model to deproject 2-d luminosity functions (LF) of galaxies in the Coma cluster measured by Beijersbergen et al. 2002. We demonstrate that the shapes of the LFs change after deprojection. It is therefore essential to correct LFs for projection effects. The deprojected LFs of the central area have best-fitting Schechter parameters of M^{*}_U=-18.31^{+0.08}_{-0.08} and \alpha_U=-1.27^{+0.018}_{-0.018}, M^{*}_B=-19.79^{+0.14}_{-0.15} and \alpha_B=-1.44^{+0.016}_{-0.016} and M^{*}_r=-21.77^{+0.20}_{-0.28} and \alpha_r=-1.27^{+0.012}_{-0.012}. The corrections are not significant enough to change the previously observed trend of increasing faint end slopes with increasing distance to the cluster center. The weighted U, B, and r band slopes of the deprojected LFs show a slightly weaker steepening with increasing projected cluster radius.Comment: Accepted for publication in A&A as a Research Not

Acidity Studies of Deuterated Acids and Bases Commonly Used as Buffers in NMR Studies

Structure based drug development is currently considered to be an important strategy for drug discovery. This strategy requires that critical knowledge of the three dimensional binding site on receptor molecules be known. NMR studies are frequently employed to ascertain important structural data on individual proteins as well as complexes of proteins with ligands. Deuterium labeled acids and bases are frequently used as buffers in deuterium oxide solutions for NMR studies on the structural conformations of bioactive molecules. Since pH is an important factor in any study of the conformational and stereochemical aspects of biologically active molecules, deuterated buffers are an essential part of the NMR experiments. However, the ionization constant for deuterium oxide (1.95 x 1015) is significantly different from that of water. Therefore, a pH comparison of deuterium-labeled acids and bases in deuterium oxide with nondeuterated aqueous acids and bases was conducted. Titration curve comparisons for deuterated and nondeuterated hydrochloric acid, acetic acid, sodium formate, and TRIS (tris[hydroxymethyl] amino methane) are described. Also, the average pKas of deuterated and non-deuterated acetic acid, formic acid, and TRIS are compared

Report on holographic tests at S-band and K-band on the DSS-63 64 metre antenna

High resolution holographic tests were carried out on DSS-63 at S-band and K-band during May l985. These tests followed a mechanical retrofit which involved the addition of structural bracing to the backing structure. Geosynchronous satellite beacons were used as sources for the tests. At a resolution of 0.4m the S-band and K-band tests revealed rms deviations of the surface to be 2.73mm and 1.53mm, respectively. The difference between these two results is thought to be due mainly to contamination of the S-band surface error map by expected and generally predictable subreflector diffraction effects. The S-band map is also known to be contaminated by diffraction from the subreflector support struts and has a higher noise level than the K-band map. A list of corrections to be applied to the reflector panels is derived from the K-band map. These corrections are predicted to reduce the rms deviation from 1.53mm to 0.86mm at 0.4m resolution. Comparison with results obtained before the mechanical retrofit suggests the major effect of the added structural bracing to be reduction of a third order deformation of the reflector about its axis

A 3-D wavelet analysis of substructure in the Coma cluster: statistics and morphology

Evidence for clustering within the Coma cluster is found by means of a multiscale analysis of the combined angular-redshift distribution. We have compiled a catalogue of 798 galaxy redshifts from published surveys from the region of the Coma cluster. We examine the presence of substructure and of voids at different scales ranging from $\sim 1 to \sim 16 h^{-1}$ Mpc, using subsamples of the catalogue, ranging from $cz=3000$ km/s to $cz=28000$ km/s. Our substructure detection method is based on the wavelet transform and on the segmentation analysis. The wavelet transform allows us to find out structures at different scales and the segmentation method allows us a quantitative statistical and morphological analysis of the sample. From the whole catalogue we select a subset of 320 galaxies, with redshifts between cz=5858 km/s and cz=8168 km/s that we identify as belonging to the central region of Coma and on which we have performed a deeper analysis, on scales ranging from $180 h^{-1}$ kpc to $1.44 h^{-1}$ Mpc. Our results are expressed in terms of the number of structures or voids and their sphericity for different values of the threshold detection and at all the scales investigated. According to our analysis, there is strong evidence for multiple hierarchical substructure, on scales ranging from a few hundreds of kpc to about $4 h^{-1}$ Mpc. The morphology of these substructures is rather spherical. On the scale of $720 h^{-1}$ kpc we find two main subclusters which where also found before, but our wavelet analysis shows even more substructures, whose redshift position is approximatively marked by these bright galaxies: NGC 4934 & 4840, 4889, 4898 & 4864, 4874 & 4839, 4927, 4875.Comment: 24 pages, 6 figures. ApJ (Main Journal), accepted for publication. Added one section on statistical tests and slightly modified text and abstrac

Preparation of Novel Hydroxyethyl Amine Isosteres as Potential Cathepsin D Inhibitors

Cathepsin D is a lysosomal aspartic protease found in all mammalian cells and is considered to be one of the main catabolic proteinases. Cathepsin D has been suggested to play a role in the metastatic potential of several types of cancer. A high activated cathepsin D level in breast tumor tissue has been associated with an increased incidence of relapse and metastasis. High levels of active cathepsin D have also been found in colon cancer, prostate cancer, uterine cancer, and ovarian cancer. Hydroxyethyl isosteres with cyclic tertiary amine have proven to be clinically useful as inhibitors of aspartyl proteases similar to cathepsin D inactivity, such as the HIV-1 aspartyl protease. We have undertaken the design, via computer molecular modeling, and the synthesis of (hydroxyethyl) amine isostere inhibitors, which are similar to potent inhibitors of the aspartyl HIV-1 protease. We now report the preparation of six compounds that contain novel hydroxyethyl isosteres with cyclic tertiary amines