Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines

We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate 3-bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h−1 of DBFO.We would like to thank Syngenta Crop Protection AG (CB) and the EPSRC (SVL, grant nos. EP/K009494/1, EP/ M004120/1, and EP/K039520/1) for financial support

Les parasitoses cardiopulmonaires chez le chat, étude bibliographique

Les parasitoses cardiopulmonaires chez le chat sont des infections souvent sous-diagnostiquées, même dans les régions d'endémie, car elles ont des signes cliniques peu spécifiques et variés. Ce travail propose de faire le point sur les principaux parasites responsables : Paragonimus sp, Aelurostrongylus abstrusus, Toxoplasma gondii, Eucoleus aerophilum, Dirofilaria immitis et Cytauxzoon felis ainsi que d'autres parasites rares, par l'étude de leur biologie, de leur répartition géographique, de leur diagnostic et des traitements qui sont efficaces. Le but étant d'aider les cliniciens dans leur démarche diagnostique face à une suspicion de parasitose cardiopulmonaire. Le diagnostic définitif repose le plus souvent sur la mise en évidence des parasites directement (coproscopie, LBA, échographie, autopsie) ou indirectement (sérologie). Enfin, tous ces parasites répondent bien à un traitement anti-parasitaire, qui n'est pas toujours nécessaire, et le pronostic reste généralement bon . Cytauxzoon felis reste cependant une exception (maladie grave et parasite résistant à la plupart des antiparasitaires).MAISONS-ALFORT-Ecole Vétérin (940462302) / SudocSudocFranceF

Black grain mycetoma caused by Leptosphaeria tompkinsii

International audienceLeptosphaeria tompkinsii is a dematiaceous fungus which is rarely reported as an agent of black-grain mycetoma. We present a case involving a mycetoma of the hand of a former farmer from Mali, West Africa, who has been a resident in France for 27 years. The patient was successfully treated with surgery and the use of oral itraconazole for 6 months. Species identification was based on sexual reproductive structures observed on potato-carrot agar media and the use of internal transcribed spacer sequencing

Data supporting "Continuous preparation and use of dibromoformaldoxime as a reactive intermediate for the synthesis of 3-bromoisoxazolines"

NMR file

A Convergent Continuous Multistep Process for the Preparation of C<inf>4</inf>-Oxime-Substituted Thiazoles

We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime 7 as a key building block. A three-step sequence to 7 was designed, which for safety concerns, could only be operated in batch mode on limited scales (<< 100g). We describe herein how we addressed such a limitation, by designing a multistep continuous synthesis of this intermediate and further demonstrate the advantages of flow reactor configuration upon scaling up.Syngent