A Convergent Continuous Multistep Process for the Preparation of C<inf>4</inf>-Oxime-Substituted Thiazoles

We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime 7 as a key building block. A three-step sequence to 7 was designed, which for safety concerns, could only be operated in batch mode on limited scales (<< 100g). We describe herein how we addressed such a limitation, by designing a multistep continuous synthesis of this intermediate and further demonstrate the advantages of flow reactor configuration upon scaling up.Syngent

A Convergent Continuous Multistep Process for the Preparation of C₄‑Oxime-Substituted Thiazoles

We report a strategy designed for the rapid and convergent assembly of C₄-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal <i>O</i>-methyl oxime <b>7</b> as a key building block. A three-step sequence to <b>7</b> was designed, which, for safety concerns, could only be operated in batch mode on limited scales (≪100 g). We describe herein how we addressed such a limitation, by designing a multistep continuous synthesis of this intermediate and further demonstrate the advantages of flow reactor configuration upon scaling up

Epidemiological investigation for grouped cases of Trichosporon asahii using whole genome and IGS1 sequencing

International audienc