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A Convergent Continuous Multistep Process for the Preparation of C<inf>4</inf>-Oxime-Substituted Thiazoles
We report a strategy designed for the rapid and convergent assembly of C4-oxime substituted thiazoles. Our approach relied on 3-bromo-2-oxopropanal O-methyl oxime 7 as a key building block. A three-step sequence to 7 was designed, which for safety concerns, could only be operated in batch mode on limited scales (<< 100g). We describe herein how we addressed such a limitation, by designing a multistep continuous synthesis of this intermediate and further demonstrate the advantages of flow reactor configuration upon scaling up.Syngent
A Convergent Continuous Multistep Process for the Preparation of C<sub>4</sub>âOxime-Substituted Thiazoles
We
report a strategy designed for the rapid and convergent assembly
of C<sub>4</sub>-oxime substituted thiazoles. Our approach relied
on 3-bromo-2-oxopropanal <i>O</i>-methyl oxime <b>7</b> as a key building block. A three-step sequence to <b>7</b> was designed, which, for safety concerns, could only be operated
in batch mode on limited scales (âȘ100 g). We describe herein
how we addressed such a limitation, by designing a multistep continuous
synthesis of this intermediate and further demonstrate the advantages
of flow reactor configuration upon scaling up
Epidemiological investigation for grouped cases of Trichosporon asahii using whole genome and IGS1 sequencing
International audienc