Effect of Plasmodium vivax malaria and their density on some Haematological parameters in infected patients admitted to Wad Medani teaching hospital in Gezira state, Sudan

Background: Despite the great effort of the malaria control program in Sudan, Plasmodium vivax malaria has remained a major challenge recently, causing significant morbidity with a variety of haematological changes. Objective: This study aims to investigate the effect of Plasmodium vivax malaria and their density on some haematological parameters in patients admitted to Wad Medani teaching hospital in Gezira state, Sudan. Methods: Some haematological parameters of 160 participants, 80 infected with vivax malaria (47 male and 33 female) and 80 non-infected with malaria, who were admitted to Wad Medani teaching hospital in Gezira state, Sudan during high transmission season between August and November 2018, were evaluated for some haematological parameters. Results: The parameters (haemoglobin, haematocrit, counts of red blood cells, platelets, white blood cells, lymphocytes, monocytes and eosinophils) were significantly lower in infected patients than malaria negatives. The platelets and haemoglobin were inversely correlated to parasite density in positive cases. Conclusion: The exhibition of some haematological parameters changes was closely related to patients infected with vivax malaria versus non-infected, and these changes could be used as a diagnostic criterion for vivax malaria diagnosis in endemic regions

Effect of Plasmodium Vivax Malaria and Their Density on Some Haematological Parameters in Infected Patients Admitted to Wad Medani Teaching Hospital in Gezira State, Sudan

Background: Despite the great effort of the malaria control program in Sudan, Plasmodium vivax malaria has remained a major challenge recently, causing significant morbidity with a variety of haematological changes. Objective: This study aims to investigate the effect of Plasmodium vivax malaria and their density on some haematological parameters in patients admitted to Wad Medani teaching hospital in Gezira state, Sudan. Methods: Some haematological parameters of 160 participants, 80 infected with vivax malaria (47 male and 33 female) and 80 non-infected with malaria, who were admitted to Wad Medani teaching hospital in Gezira state, Sudan during high transmission season between August and November 2018, were evaluated for some haematological parameters. Results: The parameters (haemoglobin, haematocrit, counts of red blood cells, platelets, white blood cells, lymphocytes, monocytes and eosinophils) were significantly lower in infected patients than malaria negatives. The platelets and haemoglobin were inversely correlated to parasite density in positive cases. Conclusion: The exhibition of some haematological parameters changes was closely related to patients infected with vivax malaria versus non-infected, and these changes could be used as a diagnostic criterion for vivax malaria diagnosis in endemic regions

Long-Term Feeding with Curcumin Affects the Growth, Antioxidant Capacity, Immune Status, Tissue Histoarchitecture, Immune Expression of Proinflammatory Cytokines, and Apoptosis Indicators in Nile Tilapia, <i>Oreochromis niloticus</i>

The impact of dietary curcumin (CUR) on the growth, antioxidant activity, histomorphology of certain organs, proinflammatory cytokine production, and immune status of Oreochromis niloticus was evaluated. The fingerlings (n = 225, 41.60 ± 0.09 g/fish) were randomly allotted into five experimental groups in triplicate. Fish were fed basal diets complemented with 0, 200, 400, 600, or 800 mg curcumin/kg diet (CUR0, CUR200, CUR400, CUR600, and CUR800, respectively) for 10 weeks. An increase in fish growth was reported in the CUR200 and CUR400 groups. The feed conversion ratio was enhanced by 15% in the CUR400 group. Fish body protein content was increased in the CUR600 group (p ≤ 0.01). Body fat was decreased, and ash content was increased by CUR supplementation in a level-related way (p O. niloticus challenged with Aeromonas hydrophila was highest in the CUR200-CUR600 groups (100%) and decreased in the CUR800 group (80%). This study concluded that CUR could be added to Nile tilapia diets up to 400 mg·kg−1 to achieve better growth, antioxidant capacity, immune response, and intestinal histology. Long feeding periods on high levels of CUR (600 and 800 mg·kg−1) stimulate inflammatory reactions in fish tissues