A multicenter study investigating factors that influence initiation of return to sport functional testing following ACL reconstruction

Despite advances in surgical technique and rehabilitation following anterior cruciate ligament (ACL) reconstruction, re-injury rates after return to play (RTP) are high. There remains controversy over the most effective criteria utilized to initiate RTP functional testing following ACL reconstruction. The purpose of this study is to investigate factors that influence provider decision to initiate RTP functional testing

Revealing the higher-order spin nature of the Hall effect in non-collinear antiferromagnet Mn3Ni0.35Cu0.65N\mathrm{Mn_3Ni_{0.35}Cu_{0.65}N}

Ferromagnets generate an anomalous Hall effect even without the presence of a magnetic field, something that conventional antiferromagnets cannot replicate but noncollinear antiferromagnets can. The anomalous Hall effect governed by the resistivity tensor plays a crucial role in determining the presence of time reversal symmetry and the topology present in the system. In this work we reveal the complex origin of the anomalous Hall effect arising in noncollinear antiferromagnets by performing Hall measurements with fields applied in selected directions in space with respect to the crystalline axes. Our coplanar magnetic field geometry goes beyond the conventional perpendicular field geometry used for ferromagnets and allows us to suppress any magnetic dipole contribution. It allows us to map the in-plane anomalous Hall contribution and we demonstrate a 120$^\circ$ symmetry which we find to be governed by the octupole moment at high fields. At low fields we subsequently discover a surprising topological Hall-like signature and, from a combination of theoretical techniques, we show that the spins can be recast into dipole, emergent octupole and noncoplanar effective magnetic moments. These co-existing orders enable magnetization dynamics unachievable in either ferromagnetic or conventional collinear antiferromagnetic materials

The efficacy of preopoerative instruction in reducing anxiety following gyneoncological surgery: a case control study

<p>Abstract</p> <p>Background</p> <p>This is a quasi-experimental case control research focusing on the impact of systematic preoperative instruction on the level of postoperative anxiety in gyneoncologic patients. The population studied consists of the gyneoncologic surgery patients admitted to the Gynecologic Oncology Service at Zekai Tahir Burak Gynecology Training and Research Hospital from May to September 2010.</p> <p>Patients and methods</p> <p>Through a random sampling, 60 patients were recruited in each group. The study group was given a systematic preoperative instruction while the control group was given routine nursing care. Patients were interviewed in the postoperative period and anxiety was measured. The data-collecting tool consisted of the Individual Information Form and the State-Trait Anxiety Inventory. The collected data were analyzed by using the SPSS Program to find the frequency, the percentage, the mean and the standard variables, and the hypothesis was tested with Chi-square, variance, and t-independent test.</p> <p>Results</p> <p>It was found that the incidence rates from the post-operative anxiety score of the study group were lower than those of the control group (p < .05). The results of this research demonstrated that gyneoncologic surgery patients who were given systematic preoperative instruction felt less anxious than the ones who were given merely a routine nursing care.</p> <p>Conclusions</p> <p>Results of this study suggest that preoperative instruction programs aiming at informing gyneoncologic surgery patients at the preoperative stage should be organized in hospitals and have an essential role.</p

The Precision nEDM Measurement with UltraCold Neutrons at TRIUMF

The TRIUMF Ultra-Cold Advanced Neutron (TUCAN) collaboration aims at a precision neutron electric dipole moment (nEDM) measurement with an uncertainty of $10^{-27}\,e\cdot\mathrm{cm}$, which is an order-of-magnitude better than the current nEDM upper limit and enables us to test Supersymmetry. To achieve this precision, we are developing a new high-intensity ultracold neutron (UCN) source using super-thermal UCN production in superfluid helium (He-II) and a nEDM spectrometer. The current development status of them is reported in this article.Comment: Proceedings of the 24th International Spin Symposium (SPIN 2021), 18-22 October 2021, Matsue, Japa

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection

IMPORTANCE: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals. OBJECTIVE: To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections. DESIGN, SETTING, AND PARTICIPANTS: Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling. EXPOSURE: SARS-CoV-2 infection. MAIN OUTCOMES AND MEASURES: PASC and 44 participant-reported symptoms (with severity thresholds). RESULTS: A total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%]) were PASC positive at 6 months. CONCLUSIONS AND RELEVANCE: A definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC

Uji aktivitas analgesik senyawa asam 2-(3- klorobenzoiloksi) benzoat pada tikus putih jantan dengan uji hot plate

Analgesik adalah golongan obat-obatan yang mampu mengurangi atau menghilangkan rasa nyeri tanpa menghilangkan kesadaran. Asam salisilat merupakan obat analgesik non narkotik yang sering digunakan dalam masyarakat. Untuk dapat meningkatkan aktivitas analgesik dan menurunkan efek samping, dilakukan modifikasi struktur asam salisilat dengan cara mengubah gugus karboksil melalui pembentukan garam, ester atau amida. Asam 2-(3-klorobenzoiloksi)benzoat disintesis dengan menggunakan asam salisilat dan 3-klorobenzoil klorida. Hewan yang digunakan adalah tikus putih jantan galur Wistar sebanyak 55 ekor yang dibagi menjadi 3 kelompok, yaitu kelompok kontrol sehat (k-), kelompok pembanding dengan dosis 12,5; 25; 50; 100; dan 200 mg/kgBB dan kelompok uji dengan dosis 12,5; 25; 50; 100; dan 200 mg/kgBB. Setelah diberikan perlakuan pada masing-masing kelompok diamati respon time pada t10, t20, t30, t40, t50, t60 saat tikus diinduksi nyeri berupa panas yang dihasilkan oleh alat plantar test dengan metode hot plate. Perhitungan statistik dilakukan dengan uji one way ANOVA dilanjutkan dengan HSD. Hasil penelitian menunjukkan ED50 senyawa asam 2-(3-klorobenzoiloksi)benzoat sebesar 20,76 mg/kgBB, sedangkan nilai ED50 asam asetilsalisilat sebesar 38,27 mg/kgBB. Hal tersebut menunjukkan bahwa aktivitas analgesik senyawa asam 2-(3- klorobenzoiloksi)benzoat lebih tinggi daripada aktivitas analgesik senyawa asam asetilsalisilat pada tikus dengan metode hot plate

Uji aktivitas analgesik senyawa asam 2-(3- klorobenzoiloksi) benzoat pada tikus putih jantan dengan uji hot plate

Analgesik adalah golongan obat-obatan yang mampu mengurangi atau menghilangkan rasa nyeri tanpa menghilangkan kesadaran. Asam salisilat merupakan obat analgesik non narkotik yang sering digunakan dalam masyarakat. Untuk dapat meningkatkan aktivitas analgesik dan menurunkan efek samping, dilakukan modifikasi struktur asam salisilat dengan cara mengubah gugus karboksil melalui pembentukan garam, ester atau amida. Asam 2-(3-klorobenzoiloksi)benzoat disintesis dengan menggunakan asam salisilat dan 3-klorobenzoil klorida. Hewan yang digunakan adalah tikus putih jantan galur Wistar sebanyak 55 ekor yang dibagi menjadi 3 kelompok, yaitu kelompok kontrol sehat (k-), kelompok pembanding dengan dosis 12,5; 25; 50; 100; dan 200 mg/kgBB dan kelompok uji dengan dosis 12,5; 25; 50; 100; dan 200 mg/kgBB. Setelah diberikan perlakuan pada masing-masing kelompok diamati respon time pada t10, t20, t30, t40, t50, t60 saat tikus diinduksi nyeri berupa panas yang dihasilkan oleh alat plantar test dengan metode hot plate. Perhitungan statistik dilakukan dengan uji one way ANOVA dilanjutkan dengan HSD. Hasil penelitian menunjukkan ED50 senyawa asam 2-(3-klorobenzoiloksi)benzoat sebesar 20,76 mg/kgBB, sedangkan nilai ED50 asam asetilsalisilat sebesar 38,27 mg/kgBB. Hal tersebut menunjukkan bahwa aktivitas analgesik senyawa asam 2-(3- klorobenzoiloksi)benzoat lebih tinggi daripada aktivitas analgesik senyawa asam asetilsalisilat pada tikus dengan metode hot plate

Using injectable fillers for chin and jawline rejuvenation

Abstract Objective As the population ages, facial plastic providers must remain aware of the treatments to prevent and reverse the external signs of aging. In the mandibular region, skin laxity and soft tissue sagging in the jawline may lead to jowling and chin ptosis along with reduced chin projection. While surgical procedures, including chin implantation, may be performed, nonsurgical procedures are becoming increasingly popular due to their temporary, noninvasive, yet effective methods. This review covers the use of hyaluronic acid, calcium hydroxylapatite, poly‐l‐lactic acid, and polymethyl methacrylate in the jawline. Methods PubMed was searched for data on the mechanism of action, pertinent anatomy, indications, contraindications, technique, and evidence supporting the safety and efficacy of the fillers. Results There are a wide variety of fillers available for use in the lower face with unique characteristics and application methods. While the advantages of injectable fillers include relatively affordable cost, minimal patient discomfort, and limited recovery times, taking measures to prevent short‐ and long‐term complications is necessary for optimal results. Conclusions Understanding the benefits and limitations of injectable fillers in the jawline can help providers appropriately counsel and treat patients

Using injectable fillers for midface rejuvenation

Treatment aimed at preventing and reversing the facial aging process has grown in popularity. The aging midface is defined by classic deepening of the nasolabial folds, formation of marionette lines around the mouth, and significant atrophy of deep facial fat. While surgical options have been investigated with satisfactory and long-lasting results, nonsurgical alternatives such as soft tissue fillers are a safe and effective strategy for facial rejuvenation. This review focuses on a variety of injectable fillers available for the treatment of the aging midface, including hyaluronic acid, calcium hydroxylapatite, poly-L-lactic acid, and polymethyl methacrylate. Mechanism of action, relevant anatomy, indications/contraindications, technique, and any evidence of efficacy and safety are described. The benefits of injectable fillers include reduced patient discomfort and shorter recovery times. Understanding the advantages and limitations of injectable fillers for midface augmentation can allow providers to counsel and treat patients seeking care appropriately