Socio-demographic Characteristics of Study Participants.

<p>Socio-demographic Characteristics of Study Participants.</p

Screening profile of women attending month 24 clinic visit in the Good health for Women project cohort.

<p>Screening profile of women attending month 24 clinic visit in the Good health for Women project cohort.</p

Sexual Behaviour and STIs among Study Participants.

<p>Sexual Behaviour and STIs among Study Participants.</p

Participant characteristics at enrollment.

<p>Participant characteristics at enrollment.</p

Number of participants providing specimens at each visit.

<p>*Two women missed baseline cervico-vaginal samples due to menstruation.</p><p>Number of participants providing specimens at each visit.</p

Main reason specimen not collected (reported at first refusal) – number of participants (% of refusals).

<p>Main reason specimen not collected (reported at first refusal) – number of participants (% of refusals).</p

Total number of participants undergoing mucosal collection by gender.

<p>A. Total number of female participants in the three trials combined and the number providing each type of specimen at the three time points. B. Total combined number of male participants and the number providing specimens at each time point.</p

Multifunctional CD4+ and CD8+ T-cell responses.

<p>The diameter of each pie is scaled according to the magnitude (geometric mean). The pie charts represent <b>A.</b> CD40L+ CD4+ T cells expressing one, two or three cytokines to F4 (p24-RT-Nef- p17) peptide pools across groups A-D; <b>B.</b> CD40L+ CD4+ T cells expressing one, two or three cytokines to GRIN (Gag-RT-Int-Nef) peptide pools across groups A-D CD8+ T cells expressing one, two or three cytokines to GRIN (Gag-RT-Int-Nef) peptides pools across groups A-D and <b>C.</b> CD8+ T cells expressing one, two or three cytokines to GRIN (Gag-RT-Int-Nef) peptides pools across groups A-D. M: Months, Pre: pre-vaccination.</p

Kinetics of Humoral immune responses against the F4 fusion protein.

<p>Anti-F4 IgG antibody concentrations measured by ELISA expressed as geometric mean concentration (GMC) in mEU/ml across groups A-D. Group A = 2xF4/AS01_E / Ad35-GRIN, B = 2xF4/AS01_B / Ad35-GRIN, C = Ad35-GRIN / 2xF4/AS01_B and D = 3xCo-Ad. M = months.</p

Kinetics of CD8+ T cell responses.

<p>The magnitude of the CD8+ T cells expressing at least one cytokine among IL-2, TNF-α and IFN-γ is shown for <b>A.</b> F4 (any of p24+RT+Nef+p17 peptide pools) and <b>B.</b> GRIN (any of Gag+RT+Int+Nef peptides pools). M: Months. Gray dots: response below the cut-off to any of the 8 peptide pools; red circles: response above the cut-off to any of the 8 peptide pools. All baseline and placebo (Pbo*) groups are combined in the far right box plot. The arrows indicate when the vaccines were given for each group (lower X-axis).</p