LDH intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval.

<p>LDH intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval.</p

IgG intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval.

<p>IgG intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval.</p

Total bilirubin intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval and cutoff for DAIDS grade one severity (vertical dashed line).

<p>Total bilirubin intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval and cutoff for DAIDS grade one severity (vertical dashed line).</p

Chemistry results, U.S.-based comparison intervals, and out of range (OOR) values

*<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004401#pone.0004401-Kratz1" target="_blank">[22]</a></p>‡<p>The number and percent of African values outside the U.S.-based comparison interval</p>1<p>Excludes women from Kilifi</p>2<p>Excludes men from Masaka</p>3<p>Excludes all Masaka volunteers and males from KNH</p>4<p>No data available from KNH, Kangemi, Entebbe or Masaka</p

Neutrophil intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval and cutoff for DAIDS grade one severity (vertical dashed line).

<p>Neutrophil intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval and cutoff for DAIDS grade one severity (vertical dashed line).</p

Hemoglobin intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval and cutoff for DAIDS grade one severity (vertical dashed line).

<p>Hemoglobin intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval and cutoff for DAIDS grade one severity (vertical dashed line).</p

Hematology results, U.S.-based comparison intervals and out of range (OOR) values

*<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004401#pone.0004401-Kratz1" target="_blank">[22]</a>, except differential counts <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004401#pone.0004401-Bakerman1" target="_blank">[23]</a> and CD4/CD8 counts [Beckton Dickson package insert]</p>‡<p>The number and percent of African values outside the U.S.-based comparison interval</p>1<p>Excludes men from Kangemi and KNH, and women from Kangemi</p>2<p>Excludes women from Kangemi</p>3<p>Excludes men from Masaka</p>4<p>Excludes all Lusaka volunteers</p>5<p>Excludes all Lusaka and Entebbe volunteers, and women from Kilifi</p

Characteristics of reference sample groups by location

°<p>Range of values from the 2.5^th %ile to 97.5^th %ile</p>*<p>Includes cocaine and off-label use of prescription medications.</p

Eosinophil count intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval.

<p>Eosinophil count intervals and medians by site and gender (men: blue, women: white) including U.S.-based comparison interval.</p

Analyte results and frequency of “adverse events” graded against western-derived DAIDS AE cutoffs^*

*<p>Chemistry cutoffs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004401#pone.0004401-DAIDS1" target="_blank">[16]</a> derived from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004401#pone.0004401-Kratz1" target="_blank">[22]</a>. Hemoglobin, platelets, WBC, neutrophil, lymphocyte and CD4 counts provided in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004401#pone.0004401-DAIDS1" target="_blank">[16]</a></p