Cisplatin-induced changes of selenium levels and glutathione peroxidase activities in blood of testis tumor patients

\u3cp\u3eHaematocrit and glutathione peroxidase activity in blood, as well as selenium levels in blood, erythrocytes and plasma, were determined in 15 patients during four courses of cisplatin combination treatment for testicular teratoma. The haematocrit steadily declined, necessitating frequent blood transfusions during or after treatment. For patients without blood transfusions during treatment the reduction of the haematocrit averaged 40%. Glutathione peroxidase activity in blood declined also; for patients without blood transfusion the reduction was 30%, which is fully explained by the decrease of the haematocrit. The enzyme activity per volume of erythrocytes remained constant during the treatment. Erythrocyte selenium level did not change significantly, but plasma selenium levels of all patients dropped within each course of chemotherapy, and progressively with each subsequent course. Between cycles the levels were largely restored to almost normal values. These results may be explained by a decreasing availability of selenium in the body to maintain the normal plasma level, due to increased retention of cisplatin in tissues and subsequent alteration of selenium metabolism.\u3c/p\u3

Physical activity and obesity: is there a difference in association between the Asian- and African- Surinamese adult population?

The role of different physical activity (PA) characteristics, i.e. domain, duration and intensity in obesity prevention still requires investigation. Furthermore, ethnicity can modify the effect of PA on body composition. Therefore, we aim to describe the association between obesity and PA characteristics across the Asian- and African-Surinamese population, living in the capital of Suriname.status: publishe

Exploring cardiovascular health: the Healthy Life in Suriname (HELISUR) study. A protocol of a cross-sectional study

Obesity, hypertension and diabetes are on a dramatic rise in low-income and middle-income countries, and this foretells an overwhelming increase in chronic disease burden from cardiovascular disease. Therefore, rapid action should be taken through preventive population-based programmes. However, in these regions, data on the population distribution of cardiovascular risk factors, and of intermediate and final end points for cardiovascular disease are scarce. The Healthy Life in Suriname (HELISUR) study is a cardiovascular population study in Suriname, which is part of the Caribbean Community. The HELISUR study is dedicated to provide data on risk factors and prevalent cardiovascular disease in the multiethnic population, which is mainly of African and Asian descent. In a cross-sectional, observational population-based setting, a random representative sample of 1800 citizens aged between 18 and 70 years will be selected using a cluster household sampling method. Self-reported demographic, socioeconomic and (cardiovascular) health-related data will be collected. Physical examination will include the assessment of cardiovascular risk factors and prevalent cardiovascular disease. In addition, we will study cardiovascular haemodynamics non-invasively, as a novel intermediate outcome. Finally, fasting blood and overnight urine samples will be collected to monitor cardiometabolic risk factors. The main outcome will be descriptive in reporting the prevalence of risk factors and measures of (sub) clinical end organ damage, stratified for ethnicity and sex-age groups. Ethical approval has been obtained from the State Secretary of Health. Data analysis and manuscript submission are scheduled for 2016. Findings will be disseminated in peer-reviewed journals, and at national, regional and international scientific meetings. Importantly, data will be presented to Surinamese policymakers and healthcare workers, to develop preventive strategies to combat the rapid rise of cardiovascular diseas

Sand rprlnt requests to: Dr. Nice REDUCTION OF CISPLATIN NEPHROTOXICITY BY SODIUM SELENITE Lack of Interaction at the Pharmacokinetic Level of Both Compounds

ABSTRACT: Administration of sodium selenite (Na SeO

Assessing the feasibility of the Healthy Life in Suriname Study: using advanced hemodynamics to evaluate cardiovascular risk

Objectives. To determine the feasibility of assessing population cardiovascular risk with advanced hemodynamics in the Healthy Life in Suriname (HELISUR) study. Methods. This was a preliminary study conducted in May - June 2012 using the Technical-Economic-Legal-Operational-Scheduling (TELOS) method to assess the feasibility of the HELISUR-a large-scale, cross-sectional population study of cardiovascular risk factors and disease in Suriname. Suriname, a middle-income country in South America with a population of mostly African and Asian ethnicity, has a high risk of cardiovascular disease. A total of 135 volunteers 18 - 70 years of age participated. A health questionnaire was tested in a primary health care center, and non-invasive cardiovascular evaluations were performed in an academic health center. The cardiovascular evaluation included sitting, supine, and standing blood pressure, and intermediate endpoints, such as cardiac output, peripheral vascular resistance, pulse wave velocity, and augmentation index. Results. The TELOS testing found that communicating by cellular phone was most effective for appointment adherence, and that completion of the questionnaire often required assistance from a trained interviewer; modifications to improve the clarity of the questions are recommended. Regarding the extended cardiovascular assessments of peripheral and central hemodynamics, the findings showed these to be technically and operationally feasible and well tolerated by participants, in terms of burden and duration. Conclusions. Findings of this feasibility assessment indicate that large-scale, detailed evaluations of cardiovascular risk, including a questionnaire and advanced central and peripheral hemodynamics, are feasible in a high-risk population in a middle-income settin

Hypertension and Cardiovascular Risk Profile in a Middle-Income Setting: The HELISUR Study

BACKGROUND Hypertension is the leading risk factor responsible for premature death worldwide, but its burden has shifted to low-and middle-income countries. Therefore, we studied hypertension and cardiovascular risk in the population of Suriname, a middle-income country with a predominantly urban population of African and Asian ancestry. METHODS A random sample of 1,800 noninstitutionalized men and women aged 18-70 years was selected to be interviewed at home and examined at the local hospital for cardiovascular risk factors, asymptomatic organ damage, and cardiovascular disease. RESULTS The 1,157 participants examined (37% men) were mainly of self-defined Asian (43%) or African (39%) ancestry, mean age 43 years (SD 14). The majority of the population (71%) had hypertension or prehypertension, respectively, 40% and 31%. Furthermore, 72% was obese or overweight, while 63% had diabetes or prediabetes. Only 1% of the adult population had an optimal cardiovascular risk profile. Hypertension awareness, treatment, and control were respectively 68%, 56%, and 20%. In line with this, 22% of the adult population had asymptomatic organ damage, including increased arterial stiffness, left ventricular hypertrophy, microalbuminuria, or asymptomatic chronic kidney disease. CONCLUSIONS In this first extensive cardiovascular assessment in the general population of this middle-income Caribbean country, high prevalence of hypertension with inadequate levels of treatment and control was predominant. The findings emphasize the need for collaborative effort from national and international bodies to prioritize the implementation of affordable and sustainable public health programs that combat the escalating hypertension and cardiovascular risk factor burde

Prevalence of self-reported stroke in association with ethnic background within a multi-ethnic population in Paramaribo, Suriname: Results from the HeliSur study.

Background: Suriname is a middle-income country with a multi-ethnic population. Urbanization and ethnicity may be associated with incidence of cerebrovascular disease, but so far this has not been documented for Suriname. The objective of this study was to examine the prevalence of stroke in the capital of Suriname, and its association with ethnicity. Methods: Using the self-reported data from the ‘Healthy life in Suriname’ (HeliSur) study, we determined the prevalence of stroke in 1,478 subjects. The odds for having suffered from stroke in Javanese, Maroons and Creoles were separately compared to the odds in Hindustani. Odds ratios were adjusted for traditional risk factors including age, sex, diabetes, hypertension, dyslipidemia, and smoking, by use of multiple logistic regression analysis. Results:The overall prevalence of stroke in urban Surinameis 3.2% (95% CI 2.3 to 4.0%). Hindustani reported the highest prevalence of stroke (4.1%, 95% CI 2.4 to 5.8%) compared to the Javanese (2.0%, 95% CI 0 to 4.0%), Creoles (3.6%, 95% CI 2.7 to 4.5%) and Maroons (1.8%, 95% CI 0.5 to 3.1%). Adjusted odds ratios showed no significant association between ethnic background and stroke. Conclusions: Stroke prevalence is high in urban Suriname, and there seems to be ethnic difference in its prevalence. However, with and without adjustments for traditional risk factors, no significant association between stroke and ethnicity could be shown.</p

Aortic pulse wave velocity in individuals of Asian and African ancestry: the HELISUR study

Aortic pulse wave velocity has emerged as an important predictor of cardiovascular events, but data on ethnic differences in pulse wave velocity remain scarce. We explored differences in pulse wave velocity between people of Asian and African ancestry. Data were used from the cross-sectional Healthy Life in Suriname (HELISUR) study. Pulse wave velocity was estimated oscillometrically with the Arteriograph. We included 353 Asians and 364 Africans, aged respectively 44.9 (SD 13.5) and 42.8 (SD 14.1) years (p = 0.05). Crude median PWV was higher in Asians than in Africans (8.1 [IQR 6.9–10.1] m/s vs. 7.7 [IQR 6.5–9.3] m/s, p = 0.03), which was mainly attributable to an increased PWV in Asians ≥ 50 years (10.1 [IQR 8.7–11.8] m/s vs. 9.1 [IQR 7.9–11.3] m/s in Africans ≥50 years, p < 0.01). After adjustment for age and MAP in multivariable linear regression, Asians had a 1.044 [95% CI 1.019–1.072] m/s higher PWV compared to Africans. Additional adjustment for sex, glucose, total cholesterol, HDL cholesterol, triglycerides, BMI, and waist circumference did not substantially change the difference in pulse wave velocity between Asians and Africans (+1.044 [95% CI 1.016–1.074] m/s for Asians vs. Africans). In conclusion, persons of Asian ancestry have a higher pulse wave velocity than those of African ancestry. This persisted after adjustment for important cardiovascular risk parameters, including age and blood pressure. The higher PWV found in Asians could be consistent with their increased coronary heart disease risk

Prevalence of self-reported stroke in association with ethnic background within a multi-ethnic population in Paramaribo, Suriname: Results from the helisur study

Background: Suriname is a middle-income country with a multi-ethnic population. Urbanization and ethnicity may be associated with incidence of cerebrovascular disease, but so far this has not been documented for Suriname. The objective of this study was to examine the prevalence of stroke in the capital of Suriname, and its association with ethnicity. Methods: Using the self-reported data from the ‘Healthy life in Suriname’ (HeliSur) study, we determined the prevalence of stroke in 1,478 subjects. The odds for having suffered from stroke in Javanese, Maroons and Creoles were separately compared to the odds in Hindustani. Odds ratios were adjusted for traditional risk factors including age, sex, diabetes, hypertension, dyslipidemia, and smoking, by use of multiple logistic regression analysis. Results:The overall prevalence of stroke in urban Surinameis 3.2% (95% CI 2.3 to 4.0%). Hindustani reported the highest prevalence of stroke (4.1%, 95% CI 2.4 to 5.8%) compared to the Javanese (2.0%, 95% CI 0 to 4.0%), Creoles (3.6%, 95% CI 2.7 to 4.5%) and Maroons (1.8%, 95% CI 0.5 to 3.1%). Adjusted odds ratios showed no significant association between ethnic background and stroke. Conclusions: Stroke prevalence is high in urban Suriname, and there seems to be ethnic difference in its prevalence. However, with and without adjustments for traditional risk factors, no significant association between stroke and ethnicity could be shown.Biomechanical EngineeringBiomechatronics & Human-Machine Contro