Daddy...? Yes, Son...?

By the time you are ready for college, Greg, you will be bigger and so will Iowa State College. Not even the latest model crystal ball can help me predict all the changes we\u27ll see in 1970

Transport visions network - Report 2 - Transportation requirements

This is the second in a series of reports to be produced by the Transport Visions Network. The Network is a novel venture to project the views of young professionals into the debate concerning the future of transport and its role in society. It is comprised of individuals who are aged 35 or under from universities, consultancies and public authorities both in the UK and overseas.This report might be deemed, in effect, to be a statement of Transport Visions Network policy - an advisory framework within which to subsequently pursue specific visions for the future of transport. The report sets out twelve Transportation Requirements that have emerged from extensive discussion and debate

Transport visions network - Report 1 - Society and lifestyles

This is the first in a series of reports to be produced by the Transport Visions Network. The Network is a novel venture to project the views of young professionals into the debate concerning the future of transport and its role in society. It is comprised of individuals who are aged 35 or under from universities, consultancies and public authorities both in the UK and overseas.Travel is a derived demand. In this report, a scenario planning approach is taken to examine future possibilities for society and lifestyle. Three pairs of scenarios are developed and described: (i) community oriented society versus individual oriented society; (ii) free-marked oriented society versus government interventionist society; and (iii) workplace to the workers versus workers to the workplace

Transport Visions Network - Report 3 - Land Use Planning

This is the third in a series of reports to be produced by the Transport Visions Network. The Network is a novel venture to project the views of young professionals into the debate concerning the future of transport and its role in society. It is comprised of individuals who are aged 35 or under from universities, consultancies and public authorities both in the UK and overseas.This report addresses land use planning. Land use planning and transportation are very much inter-related and the Network has sought to identify new ways of planning development that might help in overcoming the transport problems we face today and that might facilitate the development of transport systems in the future that better serve our needs. The report has four main sections each of which deals with a different aspect of land use planning: (i) settlement form; (ii) where we live; (iii) economic push and pull; and (iv) rural and urban environments

Transport visions network - Report 4 - Vehicles and infrastructure

This is the fourth in a series of reports to be produced by the Transport Visions Network. The Network is a novel venture to project the views of young professionals into the debate concerning the future of transport and its role in society. It is comprised of individuals who are aged 35 or under from universities, consultancies and public authorities both in the UK and overseas.This report examines how vehicles and infrastructure might be used to develop the UK’s surface transport networks of the future. In doing so, it has attempted to highlight the balance between maintaining existing systems and making the best use of technological advances to develop new vehicles and new systems. Technological advances offer the opportunity to increase the capacity that any system of infrastructure can provide. Preferably technology should be harnessed to develop systems that increase the number of people per hour that we move rather than the number of vehicles per hour. Measures such as dedicated lanes and intelligent charging can facilitate this. Similarly, greater support for car sharing and innovative forms of shared vehicle ownership could help achieve such aims. The improvements in throughput in people per hour achieved through these measures may also deliver vastly enhanced energy efficiency per kilometre moved

The solution structure of sarafotoxin-c: implications for ligand recognition by endothelin

The solution structure of sarafotoxin-c has been determined using NMR spectroscopy. A total of 112 interproton distance constraints derived from two-dimensional MMR spectra were used to calculate a family of structures using a combination of distance geometry and dynamical simulated annealing calculations. The structures reveal a well defined cu helix extending from Glu(9) to Cys(15) and an N-terminal region (Cys(1)-Asp(8)) that is tightly constrained by disulfide bands to Cys residues in the central helix. In contrast, the C-terminal region (His(16)-Trp(21)) does not adopt a defined conformation in the final family of structures. This is consistent with the paucity of NMR-derived structural constraints obtained for this region and leads to the suggestion that the C-terminal region oscillates rapidly between a number of substantially different conformers. It is proposed that differences between the central helix of the endothelin and sarafotoxin isopeptides might be important in binding of these ligands by the G protein-coupled endothelin receptors

Dead cetacean? beach, bloat, float, sink

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Moore, M. J., Mitchell, G. H., Rowles, T. K., & Early, G. Dead cetacean? beach, bloat, float, sink. Frontiers in Marine Science, 7, (2020): 333, doi:10.3389/fmars.2020.00333.Variably buoyant, dead Cetacea may float, or sink and later bloat to refloat if ambient temperature and pressure allow sufficient decomposition gas formation and expansion. Mortality can result from acute or chronic disease, fishery entanglement, vessel collision, noxious noises, or toxicant spills. Investigators often face the daunting task of elucidating a complex series of events, in reverse order, from when and where an animal is found, and to diagnose the cause of death. Various scenarios are possible: an animal could die at sea remaining there or floating ashore, or strand on a beach alive, where it dies and, if cast high enough, remain beached to be scavenged or decompose. An animal that rests low on a beach may refloat again, through increased buoyancy from decomposition gas and favorable tides, currents, and wind. Here we review the factors responsible for the different outcomes, and how to recognize the provenance of a cetacean mortality found beached, or floating at sea. In conclusion, only some carcasses strand, or remain floating. Negatively buoyant animals that die at depth, or on the surface, and sink, may never surface, even after decomposition gas accumulation, as in cold, deep waters gas may fail to adequately reduce the density of a carcass, precluding it from returning to the surface

Illinois State University Symphony Orchestra

Braden Auditorium Sunday Afternoon September 19, 1999 3:00p.m

Spontaneous virologic suppression in HIV controllers is independent of delayed-type hypersensitivity test responsiveness

<p>Abstract</p> <p>Background</p> <p>Delayed-type hypersensitivity (DTH) testing, an in vivo assessment of cell-mediated immunity, is a predictor of HIV disease progression beyond CD4 cell count. We investigated whether preserved DTH responsiveness was characteristic of HIV controllers compared to non-controllers and individuals on suppressive HAART.</p> <p>Findings</p> <p>DTH testing consisted of ≥ 3 recall antigens applied approximately every 6 months. DTH responses were classified by the number of positive skin tests: anergic (0), partial anergic (1), or non-anergic (≥ 2). HIV controllers were compared to treatment naïve non-controllers (n = 3822) and a subgroup of non-controllers with VL < 400 copies/mL on their initial HAART regimen (n = 491). The proportion of non-anergic results at first DTH testing was similar for HIV controllers compared to non-controllers (81.9% vs. 77.6%; P = 0.22), but tended to be greater in HIV controllers compared to the HAART subgroup (81.9% vs. 74.5%; P = 0.07). Complete anergy was observed in 14 (10.1%) HIV controllers with CD4 counts ≥ 400 cells/uL. For longitudinal testing, the average percentage of non-anergic DTH determinations per participant was higher in HIV controllers compared to non-controllers (81.2 ± 31.9% vs. 70.7 ± 36.8%; P = 0.0002), however this difference was eliminated with stratification by CD4 count: 200-399 (83.4 ± 35.6% vs. 71.9 ± 40.9%; P = 0.15) and > 400 cells/uL (81.2 ± 31.5% vs. 80.4 ± 32.7%; P = 0.76).</p> <p>Conclusions</p> <p>Spontaneous virologic control was not associated with DTH responsiveness, and several HIV controllers were anergic despite having elevated CD4 counts. These findings suggest that cellular immunity assessed by DTH is not a principal factor contributing to spontaneous virologic suppression in HIV controllers.</p