Genomics: Think Global, Act Local

Long a slogan for environmentalists, “think global, act local” could be a new rallying cry for biologists. As genome-wide techniques advance and their costs drop, scientists are expanding into larger and larger territories—metagenomics, global proteomic approaches, and analyses of thousands of genomes. These massive data sets are opening up new possibilities for understanding some of the smallest details of the genome. Here, we look at four such cases—investigating the evolutionary role of insertions and deletions in the genome, connecting an orphan enzyme with its gene, mapping the fine details of chromatin structure, and characterizing global interactions between proteins and RNA—all of which depend on a combination of global thinking and local action

Proposed technical guidelines for the acquisition of clinical images of skin-related conditions

IMPORTANCE Standardizing dermatological imaging is important to improve monitoring of skin lesions and skin conditions, ensure the availability of high-quality images for teledermatology, and contribute to the development of a robust archive of skin images to be used for research

Pearson correlation coefficients of 3 observers for counts of naevi of different dermoscopic patterns in 20 participants.

<p>Pearson correlation coefficients of 3 observers for counts of naevi of different dermoscopic patterns in 20 participants.</p

Differences in old and new BNMS criteria for reticular and globular patterns.

<p>Reticular: (a) the new system specifies that lines must create a complete net; (b) lines that form open shapes do not meet the criteria. Globular: (c) globules must be present over 1/3 or more of the naevus under the old BNMS system; (d) under the new BNMS system, 3 or more globules must be present but the globules can be confined to a relatively small area.</p

Dermoscopic pattern criteria of the old BNMS classification system and new BNMS classification system.

<p>Dermoscopic pattern criteria of the old BNMS classification system and new BNMS classification system.</p