Ektomesenchymaler chondromyxoider Tumor des vorderen Zungenabschnitts

Zusammenfassung: Der ektomesenchymale chondromyxoide Tumor des vorderen Zungenabschnitts ist eine sehr seltene Entität. Insgesamt wurden in der Literatur 37Fälle mitgeteilt. Wir stellen einen 52-jährigen Mann mit einem ektomesenchymalen chondromyxoiden Tumor an typischer Lokalisation mit charakteristischer lobulärer Proliferation monomorpher Tumorzellen in einem chondromyxoiden Stroma sowie Expression der typischen immunhistochemischen Marker GFAP und S-100 vor. Trotz seiner Seltenheit sollte dieser spezielle Tumor bei umschriebenen Schwellungen des vorderen Zungenabschnitts in der Differenzialdiagnose berücksichtigt werde

From fat to FAT (CD36/SR-B2):Understanding the regulation of cellular fatty acid uptake

The molecular mechanisms underlying the cellular uptake of long-chain fatty acids and the regulation of this process have been elucidated in appreciable detail in the last decades. Two main players in this field, each discovered in the early 1990s, are (i) a membrane-associated protein first identified in adipose ('fat') tissue and referred to as putative fatty acid translocase (FAT)/CD36 (now officially designated as SR-B2) which facilitates the transport of fatty acids across the plasma membrane, and (ii) the family of transcription factors designated peroxisome proliferator-activated receptors (PPAR alpha, PPAR gamma, and PPAR(beta/delta) for which fatty acids and fatty acid metabolites are the preferred ligand. CD36/SR-B2 is the predominant membrane protein involved in fatty acid uptake into intestinal enterocytes, adipocytes and cardiac and skeletal myocytes. The rate of cellular fatty acid uptake is regulated by the subcellular vesicular recycling of CD36/SR-B2 from endosomes to the plasma membrane. Fatty acid-induced activation of PPARs results in the upregulation of the expression of genes encoding various proteins and enzymes involved in cellular fatty acid utilization. Both CD36/SR-B2 and the PPARs have been implicated in the derangements in fatty acid and lipid metabolism occurring with the development of pathophysiological conditions, such as high fat diet-induced insulin resistance and diabetic cardiomyopathy, and have been suggested as targets for metabolic intervention. In this brief review we discuss the discovery and current understanding of both CD36/SR-B2 and the PPARs in metabolic homeostasis. (C) 2016 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved

Revealing invisible brews: a new approach to the chemical identification of ancient beer

While ancient Near Eastern cuneiform texts and iconography unambiguously demonstrate the social, economic, and ritual significance of beer, direct archaeological evidence for beer production or consumption remains surprisingly rare. This scarcity of material evidence renders it difficult to extrapolate information about the ingredients and production processes of beer, on the one hand, and the paraphernalia and social contexts of its consumption, on the other. In recent decades, organic residue analysis has become an essential tool in the identification of ancient alcoholic beverages, but research on Near Eastern beer has focused largely on production and storage vessels, whose form, archaeological context, and associated macroscopic residues already indicated their use in beer production. In this paper, we present a novel field sampling protocol that prevents contamination along with a refined organic residue analysis methodology that relies on a series of co-occurring compounds to identify confidently beer in ceramic vessels. The same compounds were identified in several modern beer samples and, thus, support our identification of a similar fermented barley-based beverage in archaeological samples from the late second millennium BCE site of Khani Masi in northeastern Iraq. The results presented in this paper allow us, for the first time, to unambiguously link a diverse range of vessel types to the consumption and production of beer, identify a fundamental change in Mesopotamian consumption practices, and shed light on the cultural dimensions of Babylonia's encounter with the Zagros-Mesopotamian borderlands

One-dimensional Disordered Density Waves and Superfluids: The Role of Quantum Phase Slips and Thermal Fluctuations

The low temperature phase diagram of 1D disordered quantum systems like charge or spin density waves, superfluids and related systems is considered by a full finite T renormalization group approach, presented here for the first time. At zero temperature the consideration of quantum phase slips leads to a new scenario for the unpinning (delocalization) transition. At finite T a rich cross-over diagram is found which reflects the zero temperature quantum critical behavior.Comment: 4 pages, 2 figure

Bi2Te1.6S1.4 - a Topological Insulator in the Tetradymite Family

We describe the crystal growth, crystal structure, and basic electrical properties of Bi2Te1.6S1.4, which incorporates both S and Te in its Tetradymite quintuple layers in the motif -[Te0.8S0.2]-Bi-S-Bi-[Te0.8S0.2]-. This material differs from other Tetradymites studied as topological insulators due to the increased ionic character that arises from its significant S content. Bi2Te1.6S1.4 forms high quality crystals from the melt and is the S-rich limit of the ternary Bi-Te-S {\gamma}-Tetradymite phase at the melting point. The native material is n-type with a low resistivity; Sb substitution, with adjustment of the Te to S ratio, results in a crossover to p-type and resistive behavior at low temperatures. Angle resolved photoemission study shows that topological surface states are present, with the Dirac point more exposed than it is in Bi2Te3 and similar to that seen in Bi2Te2Se. Single crystal structure determination indicates that the S in the outer chalcogen layers is closer to the Bi than the Te, and therefore that the layers supporting the surface states are corrugated on the atomic scale.Comment: To be published in Physical Review B Rapid Communications 16 douuble spaced pages. 4 figures 1 tabl