Graphical representations (box-plot) of the EPHX1 c.377T>C genotypes with CDR_CBZ CBZ: Carbamazepine; CDR: Concentration/dose ratio.

<p>Data are mean ± standard deviations. Statistical significance for difference of means is shown (P values, one way ANOVA analysis followed by Student’s T-test).</p

Graphical representations (box-plot) of the EPHX1 c.416A>G genotypes associations with (A) CBZD:CBZ, (B) CBZD:CBZE and (C) CDR_CBZD,.

<p>CBZ: Carbamazepine; CBZD: Carbamazepine-10,11-trans dihydrodiol; CBZE: Carbamazepine-10,11-epoxide; CDR: Concentration/dose ratio. Data are mean ± standard deviations. Statistical significance for difference of means is shown (P values, one way ANOVA analysis followed by Student’s T-test).</p

Distribution of SCN1A, ABCB1, EPHX1 genes polymorphism in drug-resistant and drug-responsive epileptic patients.

<p>Distribution of SCN1A, ABCB1, EPHX1 genes polymorphism in drug-resistant and drug-responsive epileptic patients.</p

Correlation between CBZ and CBZE plasma concentrations (Pearson’s correlation coefficient R).

<p>Correlation between CBZ and CBZE plasma concentrations (Pearson’s correlation coefficient R).</p

CBZ daily dose, maintenance dose, concentration/dose adjusted ratios of CBZ, CBZE, CBZD and their concentration ratios stratified by individual SNPs genotypes.

<p>^a,b Values sharing same letter are not significantly different.</p><p>*P<0.05</p><p>**P<0.01. (one way ANOVA analysis followed by Student’s T-test). CBZE: carbamazepine-10,11-epoxide; CBZD: 10,11-dihydroxy-carbazepine.</p><p>Data are mean ± standard deviations.</p

Graphical representations (box-plot) of the sodium channels (SCN1A IVS5-91 G>A) SNPs genotypes associations with (A) CBZ daily dosage (mg/day), (B) CBZ maintenance dose (mg/kg per day), (C) CDR_CBZ and (D) CBZD:CBZ.

<p>Statistical significance for difference of means is shown (P values, one way ANOVA analysis followed by Student’s T-test).</p

Incidence of coronary heart disease (CHD), peripheral artery disease (PAD) and cardiovascular events (CVE) in the PLIC population according to the rs9370867 SNP.

<p>Panels A, B and C shows the incidence (%) of CHD, PAD and CVE for GG, AG or AA carriers of the rs9370867 IDOL SNP. Panel D shows the risk CHD, PAD and CVE for the carriers of A allele of the rs9370867 vs carriers of the G allele. Odds Ratios (OR, the 95% Confidence Interval (C.I.), adjusted for age, gender, lipid profile, systolic blood pressure, glucose levels and therapies) are not statistically significant.</p

mRNA expression of LDL-R and IDOL and LDL uptake in macrophages from N342 and S342 macrophages.

<p>Panel A shows mRNA expression for LDL-receptor and for IDOL in macrophages obtained from N342 and S342 carriers (n = 5 for both genotypes) cultured in complete RPMI medium The results, normalized for the expression of an housekeeping gene (18S), data are shown as mean ± SEM. Next flow cytometry was used to study the LDL uptake in macrophages obtained from N342 or S342 carriers. To determine the LDL uptake, macrophages were incubated with fluorescently labelled LDL (DiO-LDL, 10 μg/mL) for 2 hours at 37°C. Panel B shows representative images for flow cytometry in N342 and S342 macrophages, with the gating strategy of macrophages (inside panel) and the fluorescence intensity for Dio-LDL while panel C shows the results from five N342 and five S342 patients (mean intensity fluorescence is given, mean ± SEM is shown).</p

Anthropometric and biochemical characteristics according to the rs9370867 SNP in subjects from the PLIC population.

<p>Anthropometric and biochemical characteristics according to the rs9370867 SNP in subjects from the PLIC population.</p

Heart left ventricular mass and carotid intima media thickness of the common carotid arteries in the PLIC population according to the rs9370867 IDOL SNP.

<p>Panel A shows the mean ± SD for left ventricular mass for GG, AG or AA carriers. Panel B shows the mean ± SD of carotid intima media thickness of the common carotid arteries (right and left) for GG, AG or AA carriers.</p