Additional file 2: of Identifying the participant characteristics that predict recruitment and retention of participants to randomised controlled trials involving children: a systematic review

Search terms and strategy – systematic review database search terms and search strategy. (DOCX 15 kb

Characteristics of the patients on admission and their outcomes up to one year post discharge.

<p>Characteristics of the patients on admission and their outcomes up to one year post discharge.</p

Change in volume of most affected temporal lobe over time.

<p>Patients 1 and 3 received corticosteroids during their care in hospital.</p

Coronal T2-weighted FLAIR images of a 45 year old woman with HSV encephalitis (Patient 3).

<p>On day 7 of admission a five-day course of corticosteroids was started. The same image slice is depicted from the day 2 scan (Image 1), from day 6 (Image 2) and from day 21 (Image 3)</p

Details of the scan parameters for each patient.

<p>Details of the scan parameters for each patient.</p

Change in volume of total oedema over time.

<p>Patients 1 and 3 received corticosteroids during their care in hospital.</p

Image using the easymeasure stereology, point counting software showing the landmarks for temporal lobe measurements.

<p>(1) where the lateral ventricle splits into the temporal and frontal horns as the posterior limit for the right temporal lobe in a HSV encephalitis patient; (2) the mid point of the right temporal lobe measurement (in yellow the previously calculated left temporal lobe calculation); (3) the anterior limit of the temporal lobe and (4) the mid point section in (2) showing the volume of the overall damage including that outwith the temporal lobe, where HSV is seen to affect the right temporal lobe on this slice.</p

A 2x2 table demonstrating whether volume changes increased or decreased in the two groups of patients, those treated with corticosteroids and those that were not.

<p>A 2x2 table demonstrating whether volume changes increased or decreased in the two groups of patients, those treated with corticosteroids and those that were not.</p

Flow chart of inclusion of patients in this study.

<p>Flow chart of inclusion of patients in this study.</p

Additional file 1: of A new primary dental care service compared with standard care for child and family to reduce the re-occurrence of childhood dental caries (Dental RECUR): study protocol for a randomised controlled trial

Modified dental contemplation ladder. (DOCX 91 kb