2 research outputs found
Genetic and biological characterization of a densovirus isolate that affects dengue virus infection
Genetic and biological characterization of a densovirus isolate that affects dengue virus infection
Brevidensoviruses have an encapsidated, single-stranded DNA genome that
predominantly has a negative polarity. In recent years, they have
received particular attention due to their potential role in the
biological control of pathogenic arboviruses and to their unnoticed
presence in cell cultures as contaminants. In addition,
brevidensoviruses may also be useful as viral vectors. This study
describes the first genetic and biological characterization of a
mosquito densovirus that was isolated in Brazil; moreover, we examined
the phylogenetic relationship between this isolate and the other
brevidensoviruses. We further demonstrate that this densovirus has the
potential to be used to biologically control dengue virus (DENV)
infection with in vitro co-infection experiments. The present study
provides evidence that this densovirus isolate is a fast-spreading
virus that affects cell growth and DENV infection