5 research outputs found
Π‘ΠΏΠΎΡΠΎΠ±Ρ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄Π° Π°Π±Π±ΡΠ΅Π²ΠΈΠ°ΡΡΡ ΠΈ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΡ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ (Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΡΡΡΡΠΊΠΎΠ³ΠΎ ΠΈ Π½Π΅ΠΌΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ·ΡΠΊΠΎΠ²)
ΠΡΠΏΡΡΠΊΠ½Π°Ρ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° 75 Ρ., 2 Π³Π»Π°Π²Ρ, 42 ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠ°.
ΠΡΠ΅Π΄ΠΌΠ΅Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΡΠΏΠΎΡΠΎΠ±Ρ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄Π° Π°Π±Π±ΡΠ΅Π²ΠΈΠ°ΡΡΡ ΠΈ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Ρ Π½Π΅ΠΌΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ·ΡΠΊΠ° Π½Π° ΡΡΡΡΠΊΠΈΠΉ ΡΠ·ΡΠΊ.
ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: Π°Π±Π±ΡΠ΅Π²ΠΈΠ°ΡΡΡΡ ΠΈ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΡ, ΠΎΡΠ½ΠΎΡΡΡΠΈΠ΅ΡΡ ΠΊ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ.
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ: Π²ΡΡΠ²ΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠ΅ ΡΠΏΠΎΡΠΎΠ±Ρ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄Π° Π°Π±Π±ΡΠ΅Π²ΠΈΠ°ΡΡΡ ΠΈ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Ρ Π½Π΅ΠΌΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ·ΡΠΊΠ° Π½Π° ΡΡΡΡΠΊΠΈΠΉ.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: Π±ΡΠ»ΠΈ ΡΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄Π° Π°Π±Π±ΡΠ΅Π²ΠΈΠ°ΡΡΡ ΠΈ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΉ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ
Π‘ΡΠ΅ΠΏΠ΅Π½Ρ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ/Π°ΠΏΡΠΎΠ±Π°ΡΠΈΡ ΡΠ°Π±ΠΎΡΡ: ΠΡΠ»ΠΎ ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½ΠΎ Π΄Π²Π΅ ΡΡΠ°ΡΡΠΈ
ΠΠ±Π»Π°ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ: Π»ΠΈΠ½Π³Π²ΠΈΡΡΠΈΠΊΠ°, ΡΠ·ΡΠΊΠΎΠ·Π½Π°Π½ΠΈΠ΅, ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅.Graduation thesis: 75 pg., 2 chapters, 42 resources.
Subject of research: translation methods of acronyms and reductions in the field of computer technology from German into Russian.
Object of research: Acronyms and reductions in the field of computer technology.
Purpose of research: : to identify the translation methods of acronyms and reductions in the field of computer technology from German into Russian.
Results of research: The features of the translation of acronyms and reductions in the area of computer technology has been revealed.
Degree of implementation /work approbation: two articles were published.
Field of application: Linguistic, theory of translatio
Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease
Charcot-Marie-Tooth (CMT) disease is a clinically and genetically heterogeneous group of peripheral neuropathies. Different chromosomal loci have been linked with three autosomal dominant, 'intermediate' types of CMT: DI-CMTA, DI-CMTB and DI-CMTC. We refined the locus associated with DI-CMTB on chromosome 19p12-13.2 to 4.2 Mb in three unrelated families with CMT originating from Australia, Belgium and North America. After screening candidate genes, we identified unique mutations in dynamin 2 (DNM2) in all families. DNM2 belongs to the family of large GTPases and is part of the cellular fusion-fission apparatus. In transiently transfected cell lines, mutations of DNM2 substantially diminish binding of DNM2 to membranes by altering the conformation of the beta3/beta4 loop of the pleckstrin homology domain. Additionally, in the Australian and Belgian pedigrees, which carry two different mutations affecting the same amino acid, Lys558, CMT cosegregated with neutropenia, which has not previously been associated with CMT neuropathies.status: publishe