Актуальность социогуманитарного подхода к исследованию конвергентных технологий в условиях современного информационно-коммуникативного пространства

The paper presents theoretical and methodological dimensions of convergent technologies and risks connected with them. These risks stipulate for the adequate socio-humanistic analysis of the practical applications of these technologies

Physical simulation of wind pressure on building models at various arrangement and airflow conditions

The results of modeling and distribution of the pressure coefficient on the faces of the faces of the model of a high-rise building with a relative height of H/a = 3 and 6 are obtained under the influence of vortex flows created by an obstacle with similar geometric parameters with its lateral displacement from the longitudinal axis of the channel. The accepted range of transverse displacements is L2/a = 0.5; 1; 1.5; 2. In the range of studies, the airflow angle of 0 degrees was adopted with the maximum Reynolds number (Re) = 4.25´104. The distances between the models in the wake correspond to the calibers L1/a = 1.5; 3 and 6. A series of experiments was carried out on the basis of the theory of modeling. The experiments are based on the modeling of the model buildings under study on the basis of the similarity theory. Systematic data are obtained on the distribution of the pressure coefficients Cp on the faces of the model, depending on its location in the track of the upstream model with a change in the distance between them in the transverse direction relative to the direction of the air flow

Information environment of project training accommodation

The article considers the issues of information support for project teaching of students. The configuration and composition of the information environment based on the areas of knowledge of project management

Photocatalytic degradation of diclofenac in wastewater using ironceramic composites

The photocatalytic degradation of diclofenac in model aqueous solution is investigated. The surface of composites were correlated with photocatalytic activity. Adsorption activity of the composites is related to the presence of surface active sites. The degradation under UV irradiation and photo-Fenton process using ironceramic composites is more effective than direct photolysis

Моделирование наземных испытаний рефлекторов антенн космических аппаратов на стенде с активной системой обезвешивания

Объектом исследования является стенд для раскрытия рефлектора антенны с восемью спицами диаметром 8,6 метров. Цель работы – моделирование наземных испытаний рефлекторов антенн космического аппарата (КА) на стенде с активной системой обезвешивания. В процессе исследования проводился анализ существующих способов обезвешивания элементов конструкций КА, разрабатывался алгоритм обезвешивания спицы, определялись кинематические зависимости углов механизма раскрытия спиц от перемещения мачты при раскрытии рефлектора антенны КА, разрабатывалась модель системы раскрытия спицы.The object of this study is to stand for the opening of the reflector antenna with eight spokes with a diameter of 8.6 meters. Objective - ground test simulation of the spacecraft antenna reflectors (CA) on a stand with an active obezveshivaniya system. The study analyzed the existing methods obezveshivaniya elements of spacecraft structures, developed an algorithm obezveshivaniya spokes, were determined according to the disclosure of the kinematic mechanism of the angles of the spokes on the displacement of the mast during the opening of the reflector antenna spacecraft designed spokes model disclosure system

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity

Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two signaling branches, one cGMP- and the other Ca(2+)-dependent, of which many signaling components have yet to be identified. The STATc stress signalling pathway feeds back on itself by upregulating the expression of STATc and STATc-regulated genes. Based on microarray studies we chose two tyrosine-kinase like proteins, Pyk3 and Phg2, as possible modulators of STATc phosphorylation and generated single and double knock-out mutants to them. Transcriptional regulation of STATc and STATc dependent genes was disturbed in pyk3(-), phg2(-), and pyk3(-)/phg2(-) cells. The absence of Pyk3 and/or Phg2 resulted in diminished or completely abolished increased transcription of STATc dependent genes in response to sorbitol, 8-Br-cGMP and the Ca(2+) liberator BHQ. Also, phospho-STATc levels were significantly reduced in pyk3(-) and phg2(-) cells and even further decreased in pyk3(-)/phg2(-) cells. The reduced phosphorylation was mirrored by a significant delay in nuclear translocation of GFP-STATc. The protein tyrosine phosphatase 3 (PTP3), which dephosphorylates and inhibits STATc, is inhibited by stress-induced phosphorylation on S448 and S747. Use of phosphoserine specific antibodies showed that Phg2 but not Pyk3 is involved in the phosphorylation of PTP3 on S747. In pull-down assays Phg2 and PTP3 interact directly, suggesting that Phg2 phosphorylates PTP3 on S747 in vivo. Phosphorylation of S448 was unchanged in phg2(-) cells. We show that Phg2 and an, as yet unknown, S448 protein kinase are responsible for PTP3 phosphorylation and hence its inhibition, and that Pyk3 is involved in the regulation of STATc by either directly or indirectly activating it. Our results add further complexities to the regulation of STATc, which presumably ensure its optimal activation in response to different environmental cues

Исследование зависимости предела динамической пластичности конструкционных материалов от скорости деформации

В процессе исследования проводились обработка и анализ результатов взрывных экспериментов с применением методов скоростной фоторегистрации и импульсной рентгенографии В результате исследованияполучены значения предела динамической пластичности и скорости деформации для спец. материала, определен характер зависимости этих величин.The paper presents the results of explosive experiments. The results were processed and analyzed using the methods of high-speed photographic recording and pulsed radiography. As results of the work, the values of the limit of dynamic plasticity and strain rate for special material as well as the nature of the dependence of these quantities are determined

Applicability of RNA standards for evaluating RT-qPCR assays and platforms

The availability of diverse RT-qPCR assay formats and technologies hinder comparability of data between platforms. Reference standards to facilitate platform evaluation and comparability are needed. We have explored using universal RNA standards for comparing the performance of a novel qPCR platform (Fluidigm® BioMark™) against the widely used ABI 7900HT system. Our results show that such standards may form part of a toolkit to evaluate the key performance characteristics of platforms