1,190 research outputs found
Weak Mixing Angle and Higgs Mass in Gauge-Higgs Unification Models with Brane Kinetic Terms
We show that the idea of Gauge-Higgs unification(GHU) can be rescued from the
constraint of weak mixing angle by introducing localized brane kinetic terms in
higher dimensional GHU models with bulk and simple gauge groups. We find that
those terms lead to a ratio between Higgs and W boson masses, which is a little
bit deviated from the one derived in the standard model. From numerical
analysis, we find that the current lower bound on the Higgs mass tends to
prefer to exceptional groups E(6), E(7), E(8) rather than other groups like
SU(3l), SO(2n+1), G(2), and F(4) in 6-dimensional(D) GHU models irrespective of
the compactification scales. For the compactification scale below 1 TeV, the
Higgs masses in 6D GHU models with SU(3l), SO(2n+1), G(2), and F(4) groups are
predicted to be less than the current lower bound unless a model parameter
responsible for re-scaling SU(2) gauge coupling is taken to be unnaturally
large enough. To see how the situation is changed in more higher dimensional
GHU model, we take 7D S^{3}/ Z_{2} and 8D T^{4}/ Z_{2} models. It turns out
from our numerical analysis that these higher dimensional GHU models with gauge
groups except for E(6) can lead to the Higgs boson whose masses are predicted
to be above the current lower bound only for the compatification scale above 1
TeV without taking unnaturally large value of the model parameter, whereas the
Higgs masses in the GHU models with E(6) are compatible with the current lower
bound even for the compatification scale below 1 TeV.Comment: 22 pages, 4 figure
Aerothermodynamic Analysis of a Reentry Brazilian Satellite
This work deals with a computational investigation on the small ballistic
reentry Brazilian vehicle SARA (acronyms for SAt\'elite de Reentrada
Atmosf\'erica). Hypersonic flows over the vehicle SARA at zero-degree angle of
attack in a chemical equilibrium and thermal non-equilibrium are modeled by the
Direct Simulation Monte Carlo (DSMC) method, which has become the main
technique for studying complex multidimensional rarefied flows, and that
properly accounts for the non-equilibrium aspects of the flows. The emphasis of
this paper is to examine the behavior of the primary properties during the high
altitude portion of SARA reentry. In this way, velocity, density, pressure and
temperature field are investigated for altitudes of 100, 95, 90, 85 and 80 km.
In addition, comparisons based on geometry are made between axisymmetric and
planar two-dimensional configurations. Some significant differences between
these configurations were noted on the flowfield structure in the reentry
trajectory. The analysis showed that the flow disturbances have different
influence on velocity, density, pressure and temperature along the stagnation
streamline ahead of the capsule nose. It was found that the stagnation region
is a thermally stressed zone. It was also found that the stagnation region is a
zone of strong compression, high wall pressure. Wall pressure distributions are
compared with those of available experimental data and good agreement is found
along the spherical nose for the altitude range investigated.Comment: The paper will be published in Vol. 42 of the Brazilian Journal of
Physic
New ophthalmosaurid ichthyosaurs from the European lower cretaceous demonstrate extensive ichthyosaur survival across the Jurassic–Cretaceous boundary
Background
Ichthyosauria is a diverse clade of marine amniotes that spanned most of the Mesozoic. Until recently, most authors interpreted the fossil record as showing that three major extinction events affected this group during its history: one during the latest Triassic, one at the Jurassic–Cretaceous boundary (JCB), and one (resulting in total extinction) at the Cenomanian-Turonian boundary. The JCB was believed to eradicate most of the peculiar morphotypes found in the Late Jurassic, in favor of apparently less specialized forms in the Cretaceous. However, the record of ichthyosaurs from the Berriasian–Barremian interval is extremely limited, and the effects of the end-Jurassic extinction event on ichthyosaurs remains poorly understood.
Methodology/Principal Findings
Based on new material from the Hauterivian of England and Germany and on abundant material from the Cambridge Greensand Formation, we name a new ophthalmosaurid, Acamptonectes densus gen. et sp. nov. This taxon shares numerous features with Ophthalmosaurus, a genus now restricted to the Callovian–Berriasian interval. Our phylogenetic analysis indicates that Ophthalmosauridae diverged early in its history into two markedly distinct clades, Ophthalmosaurinae and Platypterygiinae, both of which cross the JCB and persist to the late Albian at least. To evaluate the effect of the JCB extinction event on ichthyosaurs, we calculated cladogenesis, extinction, and survival rates for each stage of the Oxfordian–Barremian interval, under different scenarios. The extinction rate during the JCB never surpasses the background extinction rate for the Oxfordian–Barremian interval and the JCB records one of the highest survival rates of the interval.
Conclusions/Significance
There is currently no evidence that ichthyosaurs were affected by the JCB extinction event, in contrast to many other marine groups. Ophthalmosaurid ichthyosaurs remained diverse from their rapid radiation in the Middle Jurassic to their total extinction at the beginning of the Late Cretaceous
Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65.
Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide. Nuclear factor kappa B (NF-κB) transcription factors play crucial roles in clearance of invading viruses through activation of many physiological processes. Previous investigation showed that HBoV infection could significantly upregulate the level of TNF-α which is a strong NF-κB stimulator. Here we investigated whether HBoV proteins modulate TNF-α-mediated activation of the NF-κB signaling pathway. We showed that HBoV NS1 and NS1-70 proteins blocked NF-κB activation in response to TNF-α. Overexpression of TNF receptor-associated factor 2 (TRAF2)-, IκB kinase alpha (IKKα)-, IκB kinase beta (IKKβ)-, constitutively active mutant of IKKβ (IKKβ SS/EE)-, or p65-induced NF-κB activation was inhibited by NS1 and NS1-70. Furthermore, NS1 and NS1-70 didn't interfere with TNF-α-mediated IκBα phosphorylation and degradation, nor p65 nuclear translocation. Coimmunoprecipitation assays confirmed the interaction of both NS1 and NS1-70 with p65. Of note, NS1 but not NS1-70 inhibited TNF-α-mediated p65 phosphorylation at ser536. Our findings together indicate that HBoV NS1 and NS1-70 inhibit NF-κB activation. This is the first time that HBoV has been shown to inhibit NF-κB activation, revealing a potential immune-evasion mechanism that is likely important for HBoV pathogenesis
Star Formation in Galaxies Along the Hubble Sequence
Observations of star formation rates (SFRs) in galaxies provide vital clues
to the physical nature of the Hubble sequence, and are key probes of the
evolutionary properties of galaxies. The focus of this review is on the broad
patterns in the star formation properties of galaxies along the Hubble
sequence, and their implications for understanding galaxy evolution and the
physical processes that drive the evolution. Star formation in the disks and
nuclear regions of galaxies are reviewed separately, then discussed within a
common interpretive framework. The diagnostic methods used to measure SFRs are
also reviewed, and a self-consistent set of SFR calibrations is presented as an
aid to workers in the field.Comment: 41 pages, with 9 figures. To appear in Volume 36 of the Annual Review
of Astronomy and Astrophysic
Two Alleles of NF-κB in the Sea Anemone Nematostella vectensis Are Widely Dispersed in Nature and Encode Proteins with Distinct Activities
BACKGROUND. NF-κB is an evolutionarily conserved transcription factor that controls the expression of genes involved in many key organismal processes, including innate immunity, development, and stress responses. NF-κB proteins contain a highly conserved DNA-binding/dimerization domain called the Rel homology domain. METHODS/PRINCIPAL FINDINGS. We characterized two NF-κB alleles in the sea anemone Nematostella vectensis that differ at nineteen single-nucleotide polymorphisms (SNPs). Ten of these SNPs result in amino acid substitutions, including six within the Rel homology domain. Both alleles are found in natural populations of Nematostella. The relative abundance of the two NF-κB alleles differs between populations, and departures from Hardy-Weinberg equilibrium within populations indicate that the locus may be under selection. The proteins encoded by the two Nv-NF-κB alleles have different molecular properties, in part due to a Cys/Ser polymorphism at residue 67, which resides within the DNA recognition loop. In nearly all previously characterized NF-κB proteins, the analogous residue is fixed for Cys, and conversion of human RHD proteins from Cys to Ser at this site has been shown to increase DNA-binding ability and increase resistance to inhibition by thiol-reactive compounds. However, the naturally-occurring Nematostella variant with Cys at position 67 binds DNA with a higher affinity than the Ser variant. On the other hand, the Ser variant activates transcription in reporter gene assays more effectively, and it is more resistant to inhibition by a thiol-reactive compound. Reciprocal Cys<->Ser mutations at residue 67 of the native Nv-NF-κB proteins affect DNA binding as in human NF-κB proteins, e.g., a Cys->Ser mutation increases DNA binding of the native Cys variant. CONCLUSIONS/SIGNIFICANCE. These results are the first demonstration of a naturally occurring and functionally significant polymorphism in NF-κB in any species. The functional differences between these alleles and their uneven distribution in the wild suggest that different genotypes could be favored in different environments, perhaps environments that vary in their levels of peroxides or thiol-reactive compounds.National Institutes of Health (CA047763); National Science Foundation (FP-91656101-0); Environmental Protection Agency (F5E11155); Conservation International Marine Management Area Science Program; Boston University (SPRInG grant); Postdoctoral Scholar Program at the Woods Hole Oceanographic Institution; The Beacon Institute for Rivers and Estuaries; the J Seward Johnson Fund; Boston University (5 P42 ES07381
Assessment of Remote Heart Rhythm Sampling Using the AliveCor Heart Monitor to Screen for Atrial Fibrillation
Rotation Curves of Spiral Galaxies
Rotation curves of spiral galaxies are the major tool for determining the
distribution of mass in spiral galaxies. They provide fundamental information
for understanding the dynamics, evolution and formation of spiral galaxies. We
describe various methods to derive rotation curves, and review the results
obtained. We discuss the basic characteristics of observed rotation curves in
relation to various galaxy properties, such as Hubble type, structure,
activity, and environment.Comment: 40 pages, 6 gif figures; Ann. Rev. Astron. Astrophys. Vol. 39, p.137,
200
A Measure to Determine Acceptable Workload for Increasing Operational Efficiencies for the Conduct of Clinical Trials
As the demands for the conduct of clinical trials rise, it becomes increasingly important to establish a quantitative means of estimating the appropriate staffing resource to coordinate trial related activities. There has been a limited amount of research conducted to evaluate methods or tools to measure workload in the clinical trial setting. A literature search revealed a gap in the literature about tools used to measure workload and its impact on clinical trial performance and job satisfaction. The aim of this pilot project was to test the Ontario Protocol Assessment Level (OPAL) complexity rating tool in generating quantitative measurements of workload for the purpose of assessing operational efficiencies and identifying opportunities for process improvement changes. The pilot project was conducted in a clinical trials unit consisting of clinical research nurses (CRN), clinical research coordinators (CRC) and research managers who participated in the project implementation. Concepts from the Institute for Healthcare Improvement (IHI) Model for Improvement and Plan-Do-Study-Act (PDSA) were used to guide project implementation and Lean principles for the interpretation of data findings. The findings from the data showed that OPAL can be used as a quantitative means to measure workload, and to assess factors affecting operational efficiencies
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