1,988 research outputs found
Rotation-induced 3D vorticity in 4He superfluid films adsorbed on a porous glass
Detailed study of torsional oscillator experiments under steady rotation up
to 6.28 rad/sec is reported for a 4He superfluid monolayer film formed in 1
micrometer-pore diameter porous glass. We found a new dissipation peak with the
height being in proportion to the rotation speed, which is located to the lower
temperature than the vortex pair unbinding peak observed in the static state.
We propose that 3D coreless vortices ("pore vortices") appear under rotation to
explain this new peak. That is, the new peak originates from dissipation close
to the pore vortex lines, where large superfluid velocity shifts the vortex
pair unbinding dissipation to lower temperature. This explanation is confirmed
by observation of nonlinear effects at high oscillation amplitudes.Comment: 4pages, 5figure
Clinical Implementation of Germ Line Cancer Pharmacogenetic Variants During the Next-Generation Sequencing Era
Over 100 FDA-approved medications include pharmacogenetic biomarkers in the drug label, many with cancer indications referencing germline DNA variations. With the advent of next-generation sequencing (NGS) and its rapidly increasing uptake into cancer research and clinical practice, an enormous amount of data to inform documented gene-drug associations will be collected, which must be exploited to optimize patient benefit. This state-of-the-art article focuses on the implementation of germline cancer pharmacogenetics into clinical practice. Specifically, it discusses the importance of germline variation in cancer and the role of NGS in pharmacogenetic discovery and implementation. In the context of a scenario where massive NGS-based genetic information will be increasingly available to health stakeholders, this review explores the ongoing debate over the threshold of evidence necessary for implementation, provides an overview of recommendations in cancer by professional organizations and regulatory bodies, discusses limitations of current guidelines and strategies to improve third-party coverage
Search for supersolidity in 4He in low-frequency sound experiments
We present results of the search for supersolid 4He using low-frequency,
low-level mechanical excitation of a solid sample grown and cooled at fixed
volume. We have observed low frequency non-linear resonances that constitute
anomalous features. These features, which appear below about 0.8 K, are absent
in 3He. The frequency, the amplitude at which the nonlinearity sets in, and the
upper temperature limit of existence of these resonances depend markedly on the
sample history.Comment: Submitted to the Quantum Fluids and Solids Conf. Aug. 2006 Kyot
Characterizing correlations of flow oscillations at bottlenecks
"Oscillations" occur in quite different kinds of many-particle-systems when
two groups of particles with different directions of motion meet or intersect
at a certain spot. We present a model of pedestrian motion that is able to
reproduce oscillations with different characteristics. The Wald-Wolfowitz test
and Gillis' correlated random walk are shown to hold observables that can be
used to characterize different kinds of oscillations
Kinetic energy of solid neon by Monte Carlo with improved Trotter- and finite-size extrapolation
The kinetic energy of solid neon is calculated by a path-integral Monte Carlo
approach with a refined Trotter- and finite-size extrapolation. These accurate
data present significant quantum effects up to temperature T=20 K. They confirm
previous simulations and are consistent with recent experiments.Comment: Text and figures revised for minor corrections (4 pages, 3 figures
included by psfig
New measurement of the scattering cross section of slow neutrons on liquid parahydrogen from neutron transmission
Liquid hydrogen is a dense Bose fluid whose equilibrium properties are both
calculable from first principles using various theoretical approaches and of
interest for the understanding of a wide range of questions in many body
physics. Unfortunately, the pair correlation function inferred from
neutron scattering measurements of the differential cross section from different measurements reported in the literature are
inconsistent. We have measured the energy dependence of the total cross section
and the scattering cross section for slow neutrons with energies between
0.43~meV and 16.1~meV on liquid hydrogen at 15.6~K (which is dominated by the
parahydrogen component) using neutron transmission measurements on the hydrogen
target of the NPDGamma collaboration at the Spallation Neutron Source at Oak
Ridge National Laboratory. The relationship between the neutron transmission
measurement we perform and the total cross section is unambiguous, and the
energy range accesses length scales where the pair correlation function is
rapidly varying. At 1~meV our measurement is a factor of 3 below the data from
previous work. We present evidence that these previous measurements of the
hydrogen cross section, which assumed that the equilibrium value for the ratio
of orthohydrogen and parahydrogen has been reached in the target liquid, were
in fact contaminated with an extra non-equilibrium component of orthohydrogen.
Liquid parahydrogen is also a widely-used neutron moderator medium, and an
accurate knowledge of its slow neutron cross section is essential for the
design and optimization of intense slow neutron sources. We describe our
measurements and compare them with previous work.Comment: Edited for submission to Physical Review
A preliminary assessment of the effects of ATI-2042 in subjects with paroxysmal atrial fibrillation using implanted pacemaker methodology
Aims ATI-2042 (budiodarone) is a chemical analogue of amiodarone with a half life of 7 h. It is electrophysiologically similar to amiodarone, but may not have metabolic and interaction side effects. The sophisticated electrocardiograph logs of advanced DDDRP pacemakers were used to monitor the efficacy of ATI-2042. The aim of this study was to determine the preliminary efficacy and safety of ATI-2042 in patients with paroxsymal atrial fibrillation (PAF) and pacemakers.
Methods and results Six women with AF burden (AFB) between 1 and 50% underwent six sequential 2-week study periods. Patients received 200 mg bid of ATI-2042 during Period 2 (p2), 400 mg bid during p3, 600 mg bid during p4, 800 mg bid during p5, and no drug during baseline and washout (p1 and p6). Pacemaker data for the primary outcome measure AFB were downloaded during each period. Mean AFB decreased between baseline and all doses: AFB at baseline (SD) was 20.3 ± 14.6% and mean AFB at 200 mg bid was 5.2 ± 4.2%, at 400 mg bid 5.2 ± 5.2%, at 600 mg bid 2.8 ± 3.4%, and at 800 mg bid 1.5 ± 0.5%. The mean reductions in AFB at all doses of ATI-2042 were statistically significant (P < 0.005). Atrial fibrillation burden increased in washout. Atrial fibrillation episodes tended to increase with ATI-2042, but this was offset by substantial decreases in episode duration. ATI-2042 was generally well tolerated.
Conclusion ATI-2042 effectively reduced AFB over all doses studied by reducing mean episode duration. A large-scale study will be required to confirm this effect
Dissipative Chaos in Semiconductor Superlattices
We consider the motion of ballistic electrons in a miniband of a
semiconductor superlattice (SSL) under the influence of an external,
time-periodic electric field. We use the semi-classical balance-equation
approach which incorporates elastic and inelastic scattering (as dissipation)
and the self-consistent field generated by the electron motion. The coupling of
electrons in the miniband to the self-consistent field produces a cooperative
nonlinear oscillatory mode which, when interacting with the oscillatory
external field and the intrinsic Bloch-type oscillatory mode, can lead to
complicated dynamics, including dissipative chaos. For a range of values of the
dissipation parameters we determine the regions in the amplitude-frequency
plane of the external field in which chaos can occur. Our results suggest that
for terahertz external fields of the amplitudes achieved by present-day free
electron lasers, chaos may be observable in SSLs. We clarify the nature of this
novel nonlinear dynamics in the superlattice-external field system by exploring
analogies to the Dicke model of an ensemble of two-level atoms coupled with a
resonant cavity field and to Josephson junctions.Comment: 33 pages, 8 figure
Proceedings of the second "international Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST'14)
The implicit objective of the biennial "international - Traveling Workshop on
Interactions between Sparse models and Technology" (iTWIST) is to foster
collaboration between international scientific teams by disseminating ideas
through both specific oral/poster presentations and free discussions. For its
second edition, the iTWIST workshop took place in the medieval and picturesque
town of Namur in Belgium, from Wednesday August 27th till Friday August 29th,
2014. The workshop was conveniently located in "The Arsenal" building within
walking distance of both hotels and town center. iTWIST'14 has gathered about
70 international participants and has featured 9 invited talks, 10 oral
presentations, and 14 posters on the following themes, all related to the
theory, application and generalization of the "sparsity paradigm":
Sparsity-driven data sensing and processing; Union of low dimensional
subspaces; Beyond linear and convex inverse problem; Matrix/manifold/graph
sensing/processing; Blind inverse problems and dictionary learning; Sparsity
and computational neuroscience; Information theory, geometry and randomness;
Complexity/accuracy tradeoffs in numerical methods; Sparsity? What's next?;
Sparse machine learning and inference.Comment: 69 pages, 24 extended abstracts, iTWIST'14 website:
http://sites.google.com/site/itwist1
Magnetorotationally-Driven Galactic Turbulence and the Formation of Giant Molecular Clouds
Using local 3D MHD simulations, we investigate ways in which galactic
turbulence associated with the magnetorotational instability (MRI) may
influence the formation and properties of GMCs. Our disk models are vertically
stratified and subject to uniform shear. Initial magnetic fields are weak and
purely vertical. For simplicity, we adopt an isothermal equation of state. We
find that MRI-driven turbulence develops rapidly, with the saturated-state
Shakura & Sunyaev parameter alpha~(0.15-0.3) dominated by Maxwell stresses.
Many of the dimensionless characteristics of the turbulence (e.g. the ratio of
the Maxwell to Reynolds stresses) are similar to results from previous MRI
studies of accretion disks, hence insensitive to the degree of vertical disk
compression, shear rate, and the presence of self-gravity. The density-weighted
velocity dispersions in non- or weakly self-gravitating disks are sigma_x ~
sigma_y ~ (0.4-0.6)c_s and sigma_z~(0.2-0.3)c_s, suggesting that MRI can
contribute significantly to the observed level of galactic turbulence. The
saturated-state magnetic field strength B ~ 2 \mu G is similar to typical
galactic values. When self-gravity is strong enough, MRI-driven high-amplitude
density perturbations are swing-amplified to form Jeans-mass (~10^7 Msun) bound
clouds. Compared to previous unmagnetized or strongly-magnetized disk models,
the threshold for nonlinear instability in the present models occurs for
surface densities at least 50% lower, corresponding to the Toomre parameter
Q_th~1.6. We present evidence that self-gravitating clouds like GMCs formed
under conditions similar to our models can lose much of their original spin
angular momenta by magnetic braking, preferentially via fields threading
near-perpendicularly to their spin axes.Comment: 39 pages, 8 figures, to appear in ApJ, vol. 599, Dec. 20, 2003; For
better postscript figures and mpeg animations, see
http://cfa-www.harvard.edu/~wkim/FIGURE4
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