Demographic and clinical characteristics of PD patients and controls.

<p>Demographic and clinical characteristics of PD patients and controls.</p

Magnetic Resonance Imaging Features of the Nigrostriatal System: Biomarkers of Parkinson’s Disease Stages? - Fig 2

<p><b>(A): R2* values in the nigrostriatal system at different stages of PD; Fig (B): Striatal volumes at different stages of PD; (C): Shape analysis of caudate nucleus and putamen at different stages of PD relative to controls</b>. In blue no statistical difference p>0.05, from yellow to read decrease of p value from p<0.05 (p value of read surface< pvalue of yellow surface<0.05). Yellow and read surface correspond to surface contraction and thus atrophy; <b>(D): Iron overload in the MPTP mouse model of PD.</b> Mice were treated with MPTP (or not; n = 10 per group). Data are presented as the mean and SEM. Immunohistochemistry of tyrosine hydroxylase (TH) stained sections of the right substantia nigra (SN), illustrating the level of degeneration after MPTP intoxication. TH+ cell counts of both sides of the SN. *: Wilcoxon test: p<0.0001. Total iron levels in the SN, as measured by atomic absorption spectrometry. *: p = 0.035. R2* multiple-echo spin echo value (7 T MRI) in the SN (MRI performed <i>in vivo</i> prior to sacrifice and spectrometry measurements) (R2* = 1/T2*(ms-1) x 103) *: p = 0.001. Motor handicap scores (measured in a 10-minute actimetry test). Number of rearings *: p = 0.004. Maximum speed: *: p = 0.03.</p