63 research outputs found

    Keeping It Real: Making Space for Play in Early Education Policy and Practice

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    This chapter considers how the pedagogical framing of preschool activity as a preparation for a school, may be in conflict with an international consensus advocating allowing children greater control of some of their activities in preschool. The first sometimes promotes an early start to more formal learning, while the second proposes that personal responsibility and self-control and can lead to longer lasting benefits resulting from preschool experiences. A case study of changing policy and practice in Kazakhstan is used to illustrate the tensions between these two models of learning. Qualitative, semi-structured interviews with practitioners in the preschool environment were used to explore how national standards documents interact with underlying beliefs about the nature of learning in the formation of practice. The findings suggest that, as in other countries, the intention to increase child-led pedagogy may be inhibited by existing classroom-based expectations of children’s participation. The chapter considers how participatory research in play environments might help to increase awareness of the value of child-led play by focusing increased attention on how play supports learning

    A method of measuring the minute volume of the heart

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    The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.

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    Background: Multiple sclerosis outcome may be influenced by ultraviolet radiation and vitamin D synthesis, suggesting skin type and genes determining this phenotype are candidates for disability. However, though associations between melanocortin 1 receptor (MC1R) single nucleotide polymorphisms and disability are reported, some data are incompatible with their expected influence on skin type.Objective: Determine which MC1R single nucleotide polymorphisms affect disability and establish if ultraviolet radiation modifies such associations.Methods: We studied using linear regression in 525 cases, associations of the Multiple Sclerosis Severity Score (MSSS) with skin type, gender, ultraviolet radiation exposure and six MC1R single nucleotide polymorphisms (rs1805005, rs1805006, rs2228479, rs1805007, rs1805008, rs1805009).Results: CG(294) with GG(294) genotypes (rs1805009) (coefficient = -1.44, 95% CI -2.30, -0.59, mean MSSS +/- SD = 4.33 +/- 2.87) and AC(84) (rs1805006) (coefficient = 1.62, 95% CI 0.17, 3.06, mean MSSS = 7.62 +/- 2.43) were associated with MSSS. Associations with Asp294His were found in those with skin types 1/2 and 3/4, and cases stratified by ultraviolet radiation exposure. However, they were seen only in cases with a history of childhood sunburn and not in those without sunburn. We found no significant associations between exposure parameters and MSSS.Conclusions: Multiple Sclerosis outcome is influenced by interactions between host response to ultraviolet radiation and MC1R single nucleotide polymorphisms. The influence of the single nucleotide polymorphisms appears distinct from their association with skin type

    Progeria

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