Quasielastic Charged-Current Neutrino-Nucleus Scattering with Nonrelativistic Nuclear Energy Density Functionals

Charged-current neutrino-nucleus scattering is studied in the quasielastic region with the KIDS (Korea-IBS-Daegu-SKKU) nuclear energy density functional. We focus on the uncertainties stemming from the axial mass and the in-medium effective mass of the nucleon. Comparing the result of theory to the state-of-the-art data from MiniBooNE, T2K, and MINER$\nu$A, we constrain the axial mass and the effective mass that are compatible with the data. We find that the total cross section is insensitive to the effective mass, so the axial mass could be determined independently of the uncertainty in the effective mass. Differential cross sections at different kinematics are, on the other hand, sensitive to the effective mass as well as the axial mass. Within the uncertainty of the axial mass constrained from the total cross section, dependence on the effective mass is examined. As a result we obtain the axial mass and the effective mass that are consistent with the experimental data.Comment: 13 pages, 6 figure

Differentiation, Evaluation, and Application of Human Induced Pluripotent Stem Cell–Derived Endothelial Cells

The emergence of induced pluripotent stem cell (iPSC) technology paves the way to generate large numbers of patient-specific endothelial cells (ECs) that can be potentially delivered for regenerative medicine in patients with cardiovascular disease. In the last decade, numerous protocols that differentiate EC from iPSC have been developed by many groups. In this review, we will discuss several common strategies that have been optimized for human iPSC-EC differentiation and subsequent studies that have evaluated the potential of human iPSC-EC as a cell therapy or as a tool in disease modeling. In addition, we will emphasize the importance of using in vivo vessel-forming ability and in vitro clonogenic colony–forming potential as a gold standard with which to evaluate the quality of human iPSC-EC derived from various protocols

Neutron skin of 27^{27}Al with Skyrme and Korea-IBS-Daegu-SKKU density functionals

Recent measurement of the parity-violating (PV) asymmetry in the elastic electron scattering on $^{27}$Al target evokes the interest in the distribution of the neutron in the nucleus. In this work, we calculate the neutron skin thickness ($R_{np}$) of $^{27}$Al with nonrelativistic nuclear structure models. We focus on the role of the effective mass, symmetry energy and pairing force. Models are selected to have effective masses in the range $(0.58-1.05)M$ where $M$ is the nucleon mass in free space, and stiffness of the symmetry energy is varied by choosing the slope of the symmetry energy in the range 9.4 -- 100.5 MeV. Effect of pairing force is investigated by calculating $R_{np}$ with and without pairing, and using two different forms of the pairing force. With nine models, we obtain $R_{np} = 0.001 - 0.014$ fm. The result is independent of the effective mass, symmetry energy, and the form of pairing force. However, $R_{np}$ is negative when the pairing force is switched off, so the pairing force plays an essential role to make $R_{np}$ positive and constrained in a narrow range. We also calculate the PV asymmetry ($A_{\rm pv}$) in the elastic electron-$^{27}$Al scattering in the Born approximation at the kinematics of the Qweak experiment. We obtain a very narrow-ranged result $A_{\rm pv} =$ (2.07 -- 2.09) $\times 10^{-6}$. The result is consistent with the experiment and insensitive to the effective mass, symmetry energy and pairing force.Comment: 5 pages, 2 figure

Nuclear mass table in density functional approach inspired by neutron-star observations

Background: Nuclear energy-density functional (EDF) approach has been widely used to describe nuclear-matter equations of state (EoS) and properties of finite nuclei. Recent advancements in neutron-star (NS) observations have put constraints on the nuclear EoS. The Korea-IBS-Daegu-SKKU (KIDS) functional has been then developed to satisfy the NS observations and applied to homogeneous nuclear matter and spherical nuclei. Purpose: We examine the performance of the KIDS functional by calculating the masses and charge radii of even-even nuclei towards the drip lines. Method: The Kohn-Sham-Bogoliubov equation is solved by taking into account the axial deformation. Results: The root-mean-square deviation of the binding energy and the charge radius for the KIDS functional is 4.5--5.1 MeV and 0.03--0.04 fm, which is comparable to that for existing EDFs. The emergence and development of nuclear deformation in open-shell nuclei are well described. The location of the neutron drip line is according to the nuclear-matter parameter characterizing the low-mass NS. Conclusions: The NS-observation-inspired EDF offers a reasonable reproduction of the structures of finite nuclei. A future global optimization including more nuclear data will give better accuracy and high predictive power of neutron-rich nuclei.Comment: 9 pages, 6 figures, and 2 table

Biomarkers of Oxidative Stress and Endogenous Antioxidants for Patients with Chronic Subjective Dizziness

As a neurotologic disorder of persistent non-vertiginous dizziness, chronic subjective dizziness (CSD) arises unsteadily by psychological and physiological imbalance. The CSD is hypersensitivity reaction due to exposure to complex motions visual stimuli. However, the pathophysiological features and mechanism of the CSD still remains unclearly. The present study was purposed to establish possible endogenous contributors of the CSD using serum samples from patients with the CSD. A total 199 participants were gathered and divided into two groups; healthy (n = 152, male for 61, and female for 91) and CSD (n = 47, male for 5, female for 42), respectively. Oxidative stress parameters such as, hydrogen peroxide and reactive substances were significantly elevated (p < 0.01 or p < 0.001), whereas endogenous antioxidant components including total glutathione contents, and activities of catalase and superoxide dismutase were significantly deteriorated in the CSD group (p < 0.01 or p < 0.001) as comparing to the healthy group, respectively. Serum levels of tumor necrosis factor -α and interferon-γ were significantly increased in the CSD participants (p < 0.001). Additionally, emotional stress related hormones including cortisol, adrenaline, and serotonin were abnormally observed in the serum levels of the CSD group (p < 0.01 or p < 0.001). Our results confirmed that oxidative stress and antioxidants are a critical contributor of pathophysiology of the CSD, and that is first explored to establish features of redox system in the CSD subjects compared to a healthy population

Effects of Symmetry Energy on the Equation of State for Hybrid Neutron Stars

In this paper, the implications of the symmetry energy on the hadron and quark phase transitions in the compact star, including the properties of the possible configurations of the quark-hadron hybrid stars, are investigated in the frameworks of the energy-density functional (EDF) models and the flavor SU(2) Nambu--Jona-Lasinio (NJL) model with the help of the Schwinger's covariant proper-time regularization (PTR) scheme. In this {theoretical setup}, the equations of states (EoSs) of hadronic matter for various values of symmetry energies obtained from the EDF models are employed to describe the hadronic matter, and the {flavor} SU(2) NJL model with various repulsive-vector interaction strengths are used to describe the quark matter. We then observe the obtained EoS in the mass-radius properties of the hybrid star configurations for various vector interactions and nuclear symmetry energies by solving the Tolman-Oppenheimer-Volkoff equation. We obtain that the critical density at which the phase transition occurs varies over the density (3.6--6.7)$\rho_0$ depending on the symmetry energy and the strength of the vector coupling $G_v$. The maximum mass of the neutron star (NS) is susceptible to $G_v$. When there is no repulsive force, the NS maximum mass is only about $1.5M_\odot$, but it becomes larger than $2.0M_\odot$ when the vector coupling constant is about half of the {attractive} scalar coupling constant. Surprisingly, the presence of the quark matter does not affect the canonical mass of NS ($1.4M_\odot$), so observing the canonical mass of NSs can provide unique constraints to the EoS of hadronic matter at high densities.Comment: 20 pages, 5 figures, 1 tabl

Neutrino propagation in the neutron star with uncertainties from nuclear, hadron, and particle physics

In the present work, we investigate the neutral-current neutrino-nucleon scattering in the nuclear medium using various energy-density functional (EDF) models such as the KIDS (Korea-IBS-Daegu-SKKU) and SLy4, together with the quark-meson coupling (QMC) model for the nucleon form factors at finite density. The differential cross section (DCS) and neutrino mean free path (NMFP) are computed numerically, considering the density-dependent nucleon form factors (DDFF) and neutrino structural properties such as the neutrino magnetic moment (NMM) and its electric charge radius (NCR). It turns out that the DDFF decreases the scattering cross-section, while the NCR increases it considerably. The effect of the NMM turns out to be almost negligible. We also observe that the value of the neutron effective mass is of importance in the neutron-star cooling process, indicating that for the neutron effective mass larger than the mass in free space, the neutrino can interact with matter at densities $\rho \gtrsim 1.5 \rho_0$ in the neutron star with radius 13 km.Comment: 16 pages, 2 tables, 12 figure

Role of nucleon effective mass and symmetry energy on the neutrino mean free path in neutron star

The Korea-IBS-Daegu-SKKU energy density functional (KIDS-EDF) models, derived from the universal Skyrme functional, have been successfully and widely applied in describing the properties of finite nuclei and infinite nuclear matter. In the present work, we extend the applications of the KIDS-EDF models to investigate the implications of the nucleon effective mass and nuclear symmetry energy obtained from the KIDS-EDF models on the properties of neutron star (NS) and neutrino interaction with the NS constituents matter in the linear response approximation (LRA). We then analyze the total differential cross-section of neutrino, neutrino mean free path (NMFP), and the NS mass-radius (M-R) relations. We find that the NS M-R relations predictions for all KIDS-EDF models are in excellent agreement with the recent observations as well as the NICER result. Remarkable prediction results on the NMFPs are given by the KIDS0-m*77 and KIDS0-m*99 models with $M_n^* /M \lesssim 1$ which are quite higher in comparison with those obtained for the KIDS0, KIDS-A, and KIDS-B models with $M_n^*/M \gtrsim 1$. For the KIDS0, KIDS-A, and KIDS-B models, we obtain the $\lambda \lesssim R_{\textrm{NS}}$, indicating that these models support the slow NS cooling and neutrino trapping in NS. On the contrary, both KIDS0-m*77 and KIDS0-m*99 models support faster NS cooling and a small possibility of neutrino trapping within NS, predicting $\lambda \gtrsim R_{\textrm{NS}}$. More interestingly the NMFP decreases as the density and neutrino energy increase, which is consistent with those obtained in the Brussels-Montreal Skyrme (BSk17 and BSk18) models at saturation density.Comment: 24 pages, 2 tables, 22 figure