Global brain connectivity analysis by diffusion MR tractography:algorithms, validation and applications

The human cerebral cortex consists of approximately 1010 neurons that are organized into a complex network of local circuits and long-range connections. During the past years there has been an increasing interest from the neuro-scientific community towards the study of this network, referred to as the human connectome. Due to its ability to probe the tissue microstructure in vivo and non invasively, diffusion MRI has revealed to be a helpful tool for the analysis of brain axonal pathways at the millimeter scale. Whereas the neuronal level remains unreachable, diffusion MRI enables the mapping of a low-resolution estimate of the human connectome, which should give a new breath to the study of normal or pathologic neuroanatomy. After a short introduction on diffusion MRI and tractography, the process by which fiber tracts are reconstructed from the diffusion images, we present a methodology allowing the creation of normalized whole-brain structural connection matrices derived from tractography and representing the human connectome. Based on the developed framework we then investigate the potential of front propagation algorithms in tractography. We compare their performance with classical tractography approaches on several well-known associative fiber pathways, and we discuss their advantages and limitations. Several solutions are proposed in order to evaluate and validate the connectome-related methodology. We develop a method to estimate the respective contributions of diffusion contrast versus other effects to a tractography result. Using this methodology, we show that whereas we can have a strong confidence in mid- and long-range connections, short-range connectivity has to be interpreted with care. Next, we demonstrate the strong relationship between the structural connectivity obtained from diffusion MR tractography and the functional connectivity measured with functional MRI. Then, we compare the performance of several diffusion MRI techniques through connectome-based measurements. We find that diffusion spectrum imaging is more sensitive and therefore enhances the results of tractography. Finally, we present two network-oriented applications. We use the human connectome to reveal the small-world architecture of the brain, a very efficient network topology in terms of wiring and power supply. We identify the cortical areas that belong to the core of structural connectivity. We show that these regions also belong to the default mode network, a set of dynamically coupled brain regions that are found to be more highly activated at rest. As a conclusion, we emphasize the potential of human connectome mapping for clinical applications and pathological studies

La signification d’une science platonicienne du langage selon Jean-Toussaint Desanti dans son cours inédit « Être et relation chez Platon »

Dans son cours intitulé « Être et relation chez Platon » (1986-1987), Jean-Toussaint Desanti montre les raisons qui font que l'enquête dialectique sur la vérité de l’être chez Platon demande à ce qu’on élucide en préliminaire la question de la nature du langage et explique comment le Cratyle est pensé pour fournir cette élucidation. La construction du dialogue par Platon est éclairée par des références à l’arrière-plan historique, politique et intellectuel du débat sur la nature et l’usage du langage.In his course of 1986–87 entitled “Être et relation chez Platon”, Jean-Toussaint Desanti shows the reasons why Plato’s dialectic enquiry upon “true beeing” needs a preliminary elucidation of the nature of language and explains how the Cratylus is meant to provide it. Plato’s making of this dialogue is clarified by referring to the historical, political and intellectual background of the debate upon the nature and the use of language

Fast-Marching Tractography for Connection Matrix (Fast-TraC)

Although high angular resolution diffusion MRI techniques are able to solve multiple intra-voxel fiber orientations, the usual streamline Diffusion Spectrum Imaging (DSI) tractography algorithms present some limitations in their ability to map complex fiber-crossings in the brain white matter because they select locally only the most linear trajectories. In this work, we present a fast marching tractography algorithm for DSI, called Fast-TraC, which 1) is able to efficiently address this issue, 2) creates fiber trajectories between 1000 small cortical ROIs covering the entire brain and 3) builds a whole brain connection matrix. We also see selected tracts that are accurately reconstructed

Statistical DSI Brain Tractography: A Way to Handle the Kiss-Cross Uncertainty.

Despite the advent of diffusion magnetic resonance imaging and tractography algorithms, the accurate mapping of complex fiber kiss-crossings areas of the brain remains out of reach. In this study, we present a statistical DSI-based tractography algorithm which explores all possible paths in the brain white matter. We also introduce a cortex connectivity graph whose weighted edges correspond to the connection likelihood. The tests performed on the centrum semi-ovale have shown that a simple thresholding applied to the edges of this graph allows us to image the connectivity of any part of the brain to the desired level of complexity

How Much Confidence Do We Have in a MRI Tractography Experiment?

When performing a tractography experiment it is essential to know whether a reconstructed tract results from the diffusion signal itself or from some random effect or noise. In this study, we introduce a way to associate to every connection a confidence level. The reason why the latter greatly varies with the length of the tract is analyzed. We use this method to filter out the connections likely to be the result of noise and show the effect on the connectivity of the human visual system

Francesco Verde, Elachista. La dottrina dei minimi nell’epicureismo

À un regard superficiel et peu averti, cet ouvrage pourrait sembler ressortir au genre du « presque tout sur presque rien » : un élément extrêmement pointu et technique de la doctrine épicurienne, la théorie des minima, devient l’objet d’une enquête qui, en 354 pages, va en épuiser toutes les dimensions : textuelle, doxo­graphique, conceptuelle, systématique, historique, exégétique, etc. Mais il est en­tendu, en réalité, que le problème des elachista ne constitue en rien un détail de l’histoi..

The Early Aptian Grünten Member: Description of a new lithostratigraphic unit of the helvetic Garschella Formation

Abstract.: Early Aptian sediments mostly referred to as "upper Orbitolina beds” are known from a relatively small number of outcrop areas throughout the distal part of the Helvetic Zone of Switzerland, Austria and Germany. These sediments are here formally defined as a new, basal member of the Garschella Formation; the Grünten Member. Equivalent and correlatable sediments also exist in the Vercors region of the French Dauphinée Zone. The historical type section (holostratotype) of the Grünten Member is situated on the Grünten Mountain in southern Germany. A new type section (lectostratotype) for the Grünten Member is chosen in the better suited Bauen-Brisen area of Central Switzerland and an additional reference section (hypostratotype) is defined near the Rawil Pass in the Bernese Oberland of Switzerland. In relatively proximal settings, the Grünten Member overlies Early Aptian limestones of the Urgonian Carbonate Platform (Schrattenkalk Formation), documenting its demise and early "drowning”. In relatively distal settings, it overlies the contemporary hemipelagic sediments of the Drusberg and Mittagspitz Formations. In complete successions, the Grünten Member is in turn overlain by the basal, phosphoritic Luitere Bed of the Brisi Member (Garschella Formation) documenting the continuing "drowning” of the Urgonian Carbonate Platform in the Late Aptian. The Grünten Member essentially consists of a single stratigraphic sequence, beginning with a marly base and gradually passing to crinoidal limestones at its top. Rare ammonite finds as well as sequence stratigraphic correlations suggest a late Early Aptian age (parts of the Deshayesi and Furcata Ammonite Zones). In the relatively proximal reference section of Rawil, the Grünten Member contains two phosphoritic horizons. Phosphateenriched horizons are also known from other proximal sections of the Grünten Membe