Histological comparison of antral and corpus gastric mucosa of <i>H. pylori (HP)</i>-positive (n = 47) and -negative (n = 78) children^a.

a<p>One antral and 3 corpus gastric biopsy specimens from <i>HP</i>-positive and 7 antral and 1 corpus biopsy specimens from <i>HP</i>-negative children were deemed to be inadequate for histology assessment; n, number.</p><p>Neither atrophy, nor intestinal metaplasia was observed.</p

<i>IL1B</i>-31, <i>IL1RN</i> and <i>TNFA</i>-307 genotypic frequencies in <i>H. pylori-positive</i> (n = 47) and –<i>negative</i> children (n = 78).

a<p>It was not possible to genotype 1 <i>H. pylori</i>-positive children for <i>IL1B-</i>31 and 1 for <i>IL1RN</i>.</p>b<p>1 indicates all the long alleles and 2 the short allele. The loci did not deviate significantly from the expected Hardy-Weinberg distribution (P = 0.90 for <i>IL1B-3</i>1, P = 0.26 for <i>IL1RN</i> and P = 0.08 for <i>TNFA</i>-307) and all segregated independently.</p

Correlations between corpus IL-1β concentrations and concentrations of ferritin and haemoglobin in <i>H. pylori</i>-positive children (n = 47).

<p>Statistical analysis by Pearson’s correlation after log transformation in the case of IL-1β and ferritin.</p

Box plots representing the comparison of gastric IL-1β (A) and TNF-α (B) concentrations (pg/mg of protein) between <i>H. pylori</i>-positive (HP+, n = 47) and -negative (HP-, n = 78) children, and between antral and corpus concentration in <i>H. pylori</i>-positive and -negative groups.

<p>The upper and lower limits of the boxes represent the 75^th and 25^th percentiles, respectively. The horizontal bar across the box indicates the median and the capped bars indicate the minimum and maximum data values. Statistical analysis by Student’s t test after log transformation in the case of IL-1β; *p<0.001 and **p = 0.02.</p

Histological comparison of antral (n = 85) and corpus (n = 83) gastric mucosa of <i>H. pylori (HP)</i>-positive children and antral (n = 202) and corpus (n = 214) gastric mucosa of <i>H. pylori</i>-negative children.^*.

*<p>Twenty-four antral and 13 corpus gastric biopsy specimens were deemed to be inadequate for histology assessment. n, number.</p

Multiple linear regression models including ferritin or haemoglobin as dependent variables and age, gender, country of birth and <i>H. pylori</i> infection as independent variables in children from Chile (n = 105) and Brazil (n = 125).

<p>Multiple linear regression models including ferritin or haemoglobin as dependent variables and age, gender, country of birth and <i>H. pylori</i> infection as independent variables in children from Chile (n = 105) and Brazil (n = 125).</p

Comparison of the iron deficiency/iron deficiency anaemia parameters between <i>H. pylori</i>-positive (n = 86) and negative (n = 225) children from Brazil, Chile and United Kingdom.

*<p>obtained by dividing the serum iron concentration by the total iron binding capacity;</p><p>SD, standard deviation; MCV, mean corpuscular volume; MCH, mean corpuscular haemoglobin.</p

Multiple linear regression models including ferritin or haemoglobin as dependent variables and age, gender, country of birth and <i>H. pylori</i> infection as independent variables in children from United Kingdom, Chile and Brazil (n = 311).

<p>Multiple linear regression models including ferritin or haemoglobin as dependent variables and age, gender, country of birth and <i>H. pylori</i> infection as independent variables in children from United Kingdom, Chile and Brazil (n = 311).</p

Multiple linear regression models including ferritin or haemoglobin as dependent variables and age, gender and <i>H. pylori</i> (HP) infection as independent variables in children from United Kingdom (n = 81), Chile (n = 105) and Brazil (n = 125).

<p>Multiple linear regression models including ferritin or haemoglobin as dependent variables and age, gender and <i>H. pylori</i> (HP) infection as independent variables in children from United Kingdom (n = 81), Chile (n = 105) and Brazil (n = 125).</p