The Mediterranean world as a mission field in the first century

Typewritten sheets in cover. Thesis (M.A.)--Boston University, 1931. Bibliography: 3 p. at en

Healthy debate: medical discourses in the early novel

In the light of different views about how the early novel was distinct as a literary form, this thesis draws on those ideas that emphasise the novel’s capacity to formulate and address issues of major concern to a broad section of eighteenth-century society. Modern experience was shaped by new epistemological and socio-ethical codes, removed from traditional values and assumptions which, as a cultural instrument, the novel was designed to mediate. This thesis focuses on the novel of mid-century when, in Michael McKeon’s view, the novel first became a distinct genre, and displayed a conspicuous adaptability in tackling its explicatory and interpretative role. To the reader, the novel opened up a spectrum of (fictional) experiential possibilities. These were delivered through formal realist strategies in a literary form that was askance to established modes of cultural expression such as romance. Furthermore, formal realist strategies reflected empiricist tenets, or the gaining of knowledge through experience rather than by referral to perceived authorities, such as Church or State. One theme which recurs as a prominent area of concern is that of medical theory and practice. This thesis demonstrates how the early novel form explicated and engaged with topical medical discourses by virtue of its emergent literary qualities. These qualities include innovative narrative techniques, the portrayal of multiple perspectives, and characterisation; those attributes that strive to construct verisimilitude. Via this engagement, medical discourses served as a powerful tool to illustrate and participate in wider debates of philosophical, cultural and social significance during the period. Adopting the methodology of the case study, three contrasting representatives of the early novel are analysed with reference to three important medical debates of mid-century. The novels are The Life and Opinions of Tristram Shandy, Gentleman (1759-1767) by Laurence Sterne; The Adventures of Roderick Random (1748) by Tobias Smollett and The Adventures of Ferdinand Count Fathom (1753) also by Smollett. The debates are respectively man-midwifery and conception theories; naval medicine, and the professionalisation of medicine. Furthermore, I argue that together the case studies provide new evidence to substantiate a broader claim. They confirm John Bender’s evaluation of the eighteenth-century novel as an Enlightenment ‘knowledge system’

Sampling atmospheric sea-salt nuclei over the ocean

Atmospheric hygroscopic nuclei are of primary interest to meteorologists in studies of haze, fog, clouds, etc. (Simpson, 1941; Middleton, 1941; Sheppard, 1947). The sea surface is presumed to be an important source of these nuclei in the form of drops of concentrated sea water arising from spray

Patronage, Connoisseurship and Antiquarianism in Georgian England: The Fitzwilliam Music Collection (1763-1815)

In eighteenth-century Britain, many aristocrats studied music, participated as amateurs in musical clubs, and patronized London’s burgeoning concert life. Richard Fitzwilliam, Seventh Viscount Fitzwilliam of Merrion and Thorncastle (1745-1816), was one such patron and amateur. Fitzwilliam shaped his activities – participation, patronage, and collecting – in a unique way that illustrates his specialized tastes and interests. While as an amateur musician he sang in the Noblemen’s and Gentlemen’s Catch Club (the premiere social club dedicated to musical performance), he rose to the highest level of patronage by spearheading the Handel Commemoration Festival of 1784 and serving for many years as a Director of the Concert of Antient Music, the most prestigious concert series in Georgian Britain. His lasting legacy, however, was his bequest to Cambridge University of his extensive collection of art, books and music, as well as sufficient funds to establish the Fitzwilliam Museum. At the time of his death, Fitzwilliam’s collection of music was the best in the land, save that in the Royal Library. Thus, his collection is ideally suited for examination as proof of his activities, taste and connoisseurship. Moreover, the music in Fitzwilliam’s collection shows his participation in the contemporary musicological debate, evidenced by his advocacy for ancient music, his agreement with the views of Charles Avison and his support for the music of Domenico Scarlatti. On one side of this debate were proponents of learned, ancient music, such as Fitzwilliam and Avison, whose Essay on Musical Expression of 1752 was a milestone in musical criticism. On the other side of the discussion were advocates for the more modern, “classical” style and genres, led by historian Charles Burney

Analyzing Gene Expression from Marine Microbial Communities using Environmental Transcriptomics

Analogous to metagenomics, environmental transcriptomics (metatranscriptomics) retrieves and sequences environmental mRNAs from a microbial assemblage without prior knowledge of what genes the community might be expressing. Thus it provides the most unbiased perspective on community gene expression in situ. Environmental transcriptomics protocols are technically difficult since prokaryotic mRNAs generally lack the poly(A) tails that make isolation of eukaryotic messages relatively straightforward 1 and because of the relatively short half lives of mRNAs 2. In addition, mRNAs are much less abundant than rRNAs in total RNA extracts, thus an rRNA background often overwhelms mRNA signals. However, techniques for overcoming some of these difficulties have recently been developed. A procedure for analyzing environmental transcriptomes by creating clone libraries using random primers to reverse-transcribe and amplify environmental mRNAs was recently described was successful in two different natural environments, but results were biased by selection of the random primers used to initiate cDNA synthesis 3. Advances in linear amplification of mRNA obviate the need for random primers in the amplification step and make it possible to use less starting material decreasing the collection and processing time of samples and thereby minimizing RNA degradation 4. In vitro transcription methods for amplifying mRNA involve polyadenylating the mRNA and incorporating a T7 promoter onto the 3 end of the transcript. Amplified RNA (aRNA) can then be converted to double stranded cDNA using random hexamers and directly sequenced by pyrosequencing 5. A first use of this method at Station ALOHA demonstrated its utility for characterizing microbial community gene expression 6

Serum Iron Level is Associated with Time to Antibiotics in Cystic Fibrosis

Background: Serum levels of hepcidin‐25, a peptide hormone that reduces blood iron content, are elevated when patients with cystic fibrosis (CF) develop pulmonary exacerbation (PEx). Because hepcidin‐25 is unavailable as a clinical laboratory test, we questioned whether a one‐time serum iron level was associated with the subsequent number of days until PEx, as defined by the need to receive systemic antibiotics (ABX) for health deterioration. Methods: Clinical, biochemical, and microbiological parameters were simultaneously checked in 54 adults with CF. Charts were reviewed to determine when they first experienced a PEx after these parameters were assessed. Time to ABX was compared in subgroups with and without specific attributes. Multivariate linear regression was used to identify parameters that significantly explained variation in time to ABX. Results: In univariate analyses, time to ABX was significantly shorter in subjects with Aspergillus‐positive sputum cultures and CF‐related diabetes. Multivariate linear regression models demonstrated that shorter time to ABX was associated with younger age, lower serum iron level, and Aspergillus sputum culture positivity. Conclusions: Serum iron, age, and Aspergillus sputum culture positivity are factors associated with shorter time to subsequent PEx in CF adults

Exile Vol. XXI No. 1

FICTION Lonely Wire Hangers by Larry Weber 7-11 untitled by Peggy Gifford 15-16 Anything by Joe Bolster 20-21 Easter Story by Ellen Claffy 25-27 Melanie by Dawn Patnode 31-34 PHOTOGRAPHY by Nanny Trippe 4, 22, 24, 28 by Geoffery Yeomans 6, 11, 17, 28, 30, 35, 36, 40 POETRY untitled by Martin Cloran 5 Mirror, Mirror by Tigger Montague 12 Twenty-Two Year Decay by Tigger Montague 13 Rice Puddin\u27 by Mary Mueller 14 untitled by Sharon Singleton 18 untitled by Sharon Singleton 19 untitled by Kim McMullen 23 Audience by Dawn Patnode 29 Extinction by Vic Coccimiglio 37 The Only Way I Know Her by Vic Coccimiglio 38 Touch by Vic Coccimiglio 38 Family by Vic Coccimiglio 3

Early Agriculture in the Maya Lowlands

Wetland research in northern Belize provides the earliest evidence for development of agriculture in the Maya Lowlands. Pollen data confirm the introduction of maize and manioc before 3000 B.C. Dramatic deforestation, beginning ca. 2500 B.C. and intensifying in wetland environments ca. 1500-1300 B.C., marks an expansion of agriculture, which occurred in the context of a mixed foraging economy. By 1000 B.C. a rise in groundwater levels led farmers to construct drainage ditches coeval with the emergence of Maya complex society ca. 1000-400 B.C. Field manipulations often involved minor modifications of natural hummocks. Canal systems are not as extensive in northern Belize as previously reported, nor is there evidence of artificially raised planting platforms. By the Classic period, wetland fields were flooded and mostly abandoned

Restitution of superoxide generation in autosomal cytochrome-negative chronic granulomatous disease (A22(0) CGD)-derived B lymphocyte cell lines by transfection with p22phax cDNA

The respiratory burst oxidase of phagocytes and B lymphocytes is a multicomponent enzyme that catalyzes the one-electron reduction of oxygen by NADPH. It is responsible for the O2-production that occurs when these cells are exposed to phorbol 12-myristate 13-acetate or physiologic stimuli, such as phagocytosis in phagocytes or cross- linking of surface immunoglobulin in B lymphocytes. The activity of this enzyme is greatly diminished or absent in patients with chronic granulomatous disease (CGD), an inherited disorder characterized by a severe defect in host defense against bacteria and fungi. In every CGD patient studied so far, an abnormality has been found in a gene encoding one of the four components of the respiratory burst oxidase: the membrane proteins p22phox or gp91phox which together form the cytochrome b558 protein, or the cytosolic proteins p47phox or p67phox. Autosomal recessive cytochrome-negative CGD (A22(0) CGD) is associated with mutations in the gene coding for p22phox. We report here that the capacity for O2- production and cytochrome b558 protein expression were restored to Epstein-Barr virus-transformed B lymphocytes from two A22(0) CGD patients by transfection with an expression plasmid containing a p22phox cDNA. No detectable O2- was generated by untransfected p22phox-deficient lymphocytes. The genetic reconstitution of the respiratory burst in A22(0) CGD B lymphocytes by transfer of the wild-type p22phox cDNA represents a further step towards somatic gene therapy for this subgroup of A22(0) CGD. This system will also be useful for expression of genetically engineered mutant p22phox proteins in intact cells, facilitating the structure-function analysis of cytochrome b558

Prospectus, September 13, 1978

ELECTION DAYS ARE HERE!; Students get refund from hungry Canteen machines; Recipes for college students; CPR saves lives; Advertising Policy; PC band formed; \u27Lost in a masquerade\u27 Benson creates ecstasy; Creative writers receive assistance; Health issues program new WPCD addition; Operetta to begin tomorrow; Shaker photograph exhibition; Student Elections -- Today!; Cadaver lab is added; Apathetic turnout; Poet contest sponsored; Volleyball clinic held Sept. 9; Meeting Sept. 26 for cheerleaders; WPCD\u27s Top 15 For The Week Of Sept. 11; German club to begin activities; Classifieds; Cimmeron review \u27mediocre\u27; Thought food offered for older adults; Student Activities-\u2778; Doehring keeps on truckin\u27; Coach Jim Reed gets many players; Klems wins first Freddy contest; Cooper recruits well; Williams has busy year ahead of him; Fast Freddy Contest; Cross Country Schedulehttps://spark.parkland.edu/prospectus_1978/1012/thumbnail.jp