Stirring of sea ice meltwater enhances submesoscale fronts in the Southern Ocean

In the sea ice-impacted Southern Ocean, the spring melt of sea ice modifies the upper ocean. These modified waters subduct and enter the global overturning circulation. Submesoscale processes act to modulate the stratification of the mixed layer and therefore mixed layer properties. Sparse observations mean that the role of submesoscales in exchange across the base of the mixed layer in this region is not well constrained. The goal of this study is to determine the interplay between sea ice melt, surface boundary layer forcing, and submesoscale flows in regulating the mixed layer structure in the Antarctic Marginal Ice Zone. High-resolution observations suggest that fine-scale lateral fronts, representative of submesoscale mixed layer eddies (MLEs), arise from mesoscale gradients produced by northwards advecting sea ice meltwater. The strong salinity-driven stratification at the base of the mixed layer confined the MLEs to the upper ocean, limiting submesoscale vertical fluxes across the mixed layer base. This strong stratification prevents the local subduction by submesoscale flow of these modified waters, suggesting that the subduction site that links to the global overturning circulation does not correspond with the location of sea ice melt. However, the presence of MLEs enhanced the magnitude of lateral gradients through stirring and increased the potential for Ekman-driven cross-frontal flow to modulate the stability of the mixed layer and mixed layer properties. The inclusion, particularly of submesoscale Ekman Buoyancy Flux parameterizations, in coupled-climate models, may improve the representation of mixed layer heat and freshwater transport in the ice-impacted Southern Ocean during summer

Stirring of Sea‐Ice Meltwater Enhances Submesoscale Fronts in the Southern Ocean

In the sea‐ice‐impacted Southern Ocean, the spring sea‐ice melt and its impact on physical processes set the rate of surface water mass modification. These modified waters will eventually subduct near the polar front and enter the global overturning circulation. Submesoscale processes modulate the stratification of the mixed layer (ML) and ML properties. Sparse observations in polar regions mean that the role of submesoscale motions in the exchange of properties across the base of the ML is not well understood. The goal of this study is to determine the interplay between sea‐ice melt, surface boundary layer forcing, and submesoscale flows in setting properties of the surface ML in the Antarctic marginal ice zone. High‐resolution observations suggest that fine‐scale lateral fronts arise from either/both mesoscale and submesoscale stirring of sea‐ice meltwater anomalies. The strong salinity‐driven stratification at the base of the ML confines these fronts to the upper ocean, limiting submesoscale vertical fluxes across the ML base. This strong stratification prevents the local subduction of modified waters by submesoscale flows, suggesting that the subduction site that links to the global overturning circulation does not correspond with the location of sea‐ice melt. However, surface‐enhanced fronts increase the potential for Ekman‐driven cross‐frontal flow to modulate the stability of the ML and ML properties. The parameterization of submesoscale processes in coupled‐climate models, particularly those contributing to the Ekman buoyancy flux, may improve the representation of ML heat and freshwater transport in the ice‐impacted Southern Ocean during summer

The Nimrod computational workbench: a case study in desktop metacomputing

The coordinated use of geographically distributed computers, or metacomputing, can in principle provide more accessible and cost- effective supercomputing than conventional high-performance systems. However, we lack evidence that metacomputing systems can be made easily usable, or that there exist large numbers of applications able to exploit metacomputing resources. In this paper, we present work that addresses both these concerns. The basis for this work is a system called Nimrod that provides a desktop problem-solving environment for parametric experiments. We describe how Nimrod has been extended to support the scheduling of computational resources located in a wide-area environment, and report on an experiment in which Nimrod was used to schedule a large parametric study across the Australian Internet. The experiment provided both new scientific results and insights into Nimrod capabilities. We relate the results of this experiment to lessons learned from the I-WAY distributed computing experiment, and draw conclusions as to how Nimrod and I-WAY- like computing environments should be developed to support desktop metacomputing

Path integral Monte Carlo simulations of silicates

We investigate the thermal expansion of crystalline SiO$_2$ in the $\beta$-- cristobalite and the $\beta$-quartz structure with path integral Monte Carlo (PIMC) techniques. This simulation method allows to treat low-temperature quantum effects properly. At temperatures below the Debye temperature, thermal properties obtained with PIMC agree better with experimental results than those obtained with classical Monte Carlo methods.Comment: 27 pages, 10 figures, Phys. Rev. B (in press

Flux Phase as a Dynamic Jahn-Teller Phase: Berryonic Matter in the Cuprates?

There is considerable evidence for some form of charge ordering on the hole-doped stripes in the cuprates, mainly associated with the low-temperature tetragonal phase, but with some evidence for either charge density waves or a flux phase, which is a form of dynamic charge-density wave. These three states form a pseudospin triplet, demonstrating a close connection with the E X e dynamic Jahn-Teller effect, suggesting that the cuprates constitute a form of Berryonic matter. This in turn suggests a new model for the dynamic Jahn-Teller effect as a form of flux phase. A simple model of the Cu-O bond stretching phonons allows an estimate of electron-phonon coupling for these modes, explaining why the half breathing mode softens so much more than the full oxygen breathing mode. The anomalous properties of $O^{2-}$ provide a coupling (correlated hopping) which acts to stabilize density wave phases.Comment: Major Revisions: includes comparisons with specific cuprate phonon modes, 16 eps figures, revte

A Method for the Simultaneous Estimation of Selection Intensities in Overlapping Genes

Inferring the intensity of positive selection in protein-coding genes is important since it is used to shed light on the process of adaptation. Recently, it has been reported that overlapping genes, which are ubiquitous in all domains of life, seem to exhibit inordinate degrees of positive selection. Here, we present a new method for the simultaneous estimation of selection intensities in overlapping genes. We show that the appearance of positive selection is caused by assuming that selection operates independently on each gene in an overlapping pair, thereby ignoring the unique evolutionary constraints on overlapping coding regions. Our method uses an exact evolutionary model, thereby voiding the need for approximation or intensive computation. We test the method by simulating the evolution of overlapping genes of different types as well as under diverse evolutionary scenarios. Our results indicate that the independent estimation approach leads to the false appearance of positive selection even though the gene is in reality subject to negative selection. Finally, we use our method to estimate selection in two influenza A genes for which positive selection was previously inferred. We find no evidence for positive selection in both cases

Preliminary outcomes of a paediatric highly active antiretroviral therapy cohort from KwaZulu-Natal, South Africa

BACKGROUND: Few studies address the use of paediatric highly active antiretroviral therapy (HAART) in Africa. METHODS: We performed a retrospective cohort study to investigate preliminary outcomes of all children eligible for HAART at Sinikithemba HIV/AIDS clinic in KwaZulu-Natal, South Africa. Immunologic, virologic, clinical, mortality, primary caregiver, and psychosocial variables were collected and analyzed. RESULTS: From August 31, 2003 until October 31, 2005, 151 children initiated HAART. The median age at HAART initiation was 5.7 years (range 0.3–15.4). Median follow-up time of the cohort after HAART initiation was 8 months (IQR 3.5–13.5). The median change in CD4% from baseline (p < 0.001) was 10.2 (IQR 5.0–13.8) at 6 months (n = 90), and 16.2 (IQR 9.6–20.3) at 12 months (n = 59). Viral loads (VLs) were available for 100 children at 6 months of which 84% had HIV-1 RNA levels ≤ 50 copies/mL. At 12 months, 80.3% (n = 61) had undetectable VLs. Sixty-five out of 88 children (73.8%) reported a significant increase (p < 0.001) in weight after the first month. Eighty-nine percent of the cohort (n = 132) reported ≤ 2 missed doses during any given treatment month (> 95%adherence). Seventeen patients (11.3%) had a regimen change; two (1.3%) were due to antiretroviral toxicity. The Kaplan-Meier one year survival estimate was 90.9% (95%confidence interval (CI) 84.8–94.6). Thirteen children died during follow-up (8.6%), one changed service provider, and no children were lost to follow-up. All 13 deaths occurred in children with advanced HIV disease within 5 months of treatment initiation. In multivariate analysis of baseline variables against mortality using Cox proportional-hazards model, chronic gastroenteritis was associated with death [hazard ratio (HR), 12.34; 95%CI, 1.27–119.71) and an HIV-positive primary caregiver was found to be protective against mortality [HR, 0.12; 95%CI, 0.02–0.88). Age, orphanhood, baseline CD4%, and hemoglobin were not predicators of mortality in our cohort. Fifty-two percent of the cohort had at least one HIV-positive primary caregiver, and 38.4% had at least one primary caregiver also on HAART at Sinikithemba clinic. CONCLUSION: This report suggests that paediatric HAART can be effective despite the challenges of a resource-limited setting

Track E Implementation Science, Health Systems and Economics

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138412/1/jia218443.pd