Molecular similarity of MDR inhibitors

Everyone is free to re-use the published material if proper accreditation/citation of the original publication is given. http://creativecommons.org/licences/by/3.0/The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of inhibitors of bacterial MDR were studied and there is a high similarity between these in terms of their shape, presence and orientation of aromatic ring moieties. A comparison of the lipophilic properties of these molecules has also been conducted suggesting that this factor is important in MDR inhibition.Peer reviewe

Dilaton Black Holes Near the Horizon

Generic $U(1)^2$ 4-d black holes with unbroken $N=1$ supersymmetry are shown to tend to a Robinson-Bertotti type geometry with a linear dilaton and doubling of unbroken supersymmetries near the horizon. Purely magnetic dilatonic black holes, which have unbroken $N=2$ supersymmetry, behave near the horizon as a 2-d linear dilaton vacuum $\otimes \, S^2$. This geometry is invariant under 8 supersymmetries, i.e. half of the original $N=4$ supersymmetries are unbroken. The supersymmetric positivity bound, which requires the mass of the 4-d dilaton black holes to be greater than or equal to the central charge, corresponds to positivity of mass for a class of stringy 2-d black holes.Comment: 10 pages, SU-ITP-92-2

The Geometry of Small Causal Diamonds

The geometry of causal diamonds or Alexandrov open sets whose initial and final events $p$ and $q$ respectively have a proper-time separation $\tau$ small compared with the curvature scale is a universal. The corrections from flat space are given as a power series in $\tau$ whose coefficients involve the curvature at the centre of the diamond. We give formulae for the total 4-volume $V$ of the diamond, the area $A$ of the intersection the future light cone of $p$ with the past light cone of $q$ and the 3-volume of the hyper-surface of largest 3-volume bounded by this intersection valid to ${\cal O} (\tau ^4)$. The formula for the 4-volume agrees with a previous result of Myrheim. Remarkably, the iso-perimetric ratio ${3V_3 \over 4 \pi} / ({A \over 4 \pi}) ^{3 \over 2}$ depends only on the energy density at the centre and is bigger than unity if the energy density is positive. These results are also shown to hold in all spacetime dimensions. Formulae are also given, valid to next non-trivial order, for causal domains in two spacetime dimensions. We suggest a number of applications, for instance, the directional dependence of the volume allows one to regard the volumes of causal diamonds as an observable providing a measurement of the Ricci tensor.Comment: 17 pages, no figures; Misprints in eqs.(62), (65), (66) and (81) corrected; a new note on page 13 (with 2 new equations) adde

Branes as BIons

A BIon may be defined as a finite energy solution of a non-linear field theory with distributional sources. By contrast a soliton is usually defined to have no sources. I show how harmonic coordinates map the exteriors of the topologically and causally non-trivial spacetimes of extreme p-branes to BIonic solutions of the Einstein equations in a topologically trivial spacetime in which the combined gravitational and matter energy momentum is located on distributional sources. As a consequence the tension of BPS p-branes is classically unrenormalized. The result holds equally for spacetimes with singularities and for those, like the M-5-brane, which are everywhere singularity free.Comment: Latex, 9 pages, no figure

The Action of Instantons with Nut Charge

We examine the effect of a non-trivial nut charge on the action of non-compact four-dimensional instantons with a U(1) isometry. If the instanton action is calculated by dimensionally reducing along the isometry, then the nut charge is found to make an explicit non-zero contribution. For metrics satisfying AF, ALF or ALE boundary conditions, the action can be expressed entirely in terms of quantities (including the nut charge) defined on the fixed point set of the isometry. A source (or sink) of nut charge also implies the presence of a Misner string coordinate singularity, which will have an important effect on the Hamiltonian of the instanton.Comment: 25 page

Bohm and Einstein-Sasaki Metrics, Black Holes and Cosmological Event Horizons

We study physical applications of the Bohm metrics, which are infinite sequences of inhomogeneous Einstein metrics on spheres and products of spheres of dimension 5 <= d <= 9. We prove that all the Bohm metrics on S^3 x S^2 and S^3 x S^3 have negative eigenvalue modes of the Lichnerowicz operator and by numerical methods we establish that Bohm metrics on S^5 have negative eigenvalues too. We argue that all the Bohm metrics will have negative modes. These results imply that higher-dimensional black-hole spacetimes where the Bohm metric replaces the usual round sphere metric are classically unstable. We also show that the stability criterion for Freund-Rubin solutions is the same as for black-hole stability, and hence such solutions using Bohm metrics will also be unstable. We consider possible endpoints of the instabilities, and show that all Einstein-Sasaki manifolds give stable solutions. We show how Wick rotation of Bohm metrics gives spacetimes that provide counterexamples to a strict form of the Cosmic Baldness conjecture, but they are still consistent with the intuition behind the cosmic No-Hair conjectures. We show how the Lorentzian metrics may be created ``from nothing'' in a no-boundary setting. We argue that Lorentzian Bohm metrics are unstable to decay to de Sitter spacetime. We also argue that noncompact versions of the Bohm metrics have infinitely many negative Lichernowicz modes, and we conjecture a general relation between Lichnerowicz eigenvalues and non-uniqueness of the Dirichlet problem for Einstein's equations.Comment: 53 pages, 11 figure

Fixed Scalars and Suppression of Hawking Evaporation

For an extreme charged black hole some scalars take on a fixed value at the horizon determined by the charges alone. We call them fixed scalars. We find the absorption cross section for a low frequency wave of a fixed scalar to be proportional to the square of the frequency. This implies a strong suppression of the Hawking radiation near extremality. We compute the coefficient of proportionality for a specific model.Comment: 10 pages, late

Gravitational Instantons, Confocal Quadrics and Separability of the Schr\"odinger and Hamilton-Jacobi equations

A hyperk\"ahler 4-metric with a triholomorphic SU(2) action gives rise to a family of confocal quadrics in Euclidean 3-space when cast in the canonical form of a hyperk\"ahler 4-metric metric with a triholomorphic circle action. Moreover, at least in the case of geodesics orthogonal to the U(1) fibres, both the covariant Schr\"odinger and the Hamilton-Jacobi equation is separable and the system integrable.Comment: 10 pages Late