How Do Software Startups Pivot? Empirical Results from a Multiple Case Study

In order to handle intense time pressure and survive in dynamic market, software startups have to make crucial decisions constantly on whether to change directions or stay on chosen courses, or in the terms of Lean Startup, to pivot or to persevere. The existing research and knowledge on software startup pivots are very limited. In this study, we focused on understanding the pivoting processes of software startups, and identified the triggering factors and pivot types. To achieve this, we employed a multiple case study approach, and analyzed the data obtained from four software startups. The initial findings show that different software startups make different types of pivots related to business and technology during their product development life cycle. The pivots are triggered by various factors including negative customer feedback.Comment: Conference publication, International Conference on Software Business (ICSOB'16), Sloveni

Holographic Technidilaton and LHC searches

We analyze in detail the phenomenology of a model of dynamical electroweak symmetry breaking inspired by walking technicolor, by using the techniques of the bottom-up approach to holography. The model admits a light composite scalar state, the dilaton, in the spectrum. We focus on regions of parameter space for which the mass of such dilaton is 125 GeV, and for which the bounds on the precision electroweak parameter S are satisfied. This requires that the next-to-lightest composite state is the techni-rho meson, with a mass larger than 2.3 TeV. We compute the couplings controlling the decay rates of the dilaton to two photons and to two (real or virtual) Z and W bosons. For generic choices of the parameters, we find a suppression of the decay into heavy gauge bosons, in respect to the analog decay of the standard-model Higgs. We find a dramatic effect on the decay into photons, which can be both strongly suppressed or strongly enhanced, the latter case corresponding to the large-N regime of the dual theory. There is a correlation between this decay rate of the dilaton into photons and the mass splitting between the techni-rho meson and its axial-vector partner: if the decay is enhanced in respect to the standard-model case, then the heavy spin-1 resonances are nearly degenerate in mass, otherwise their separation in mass is comparable to the mass scale itself.Comment: Very minor typos corrected. References adde

Observations of the bright radio sources in the North Celestial Pole region at the RATAN-600 radio telescope

A survey of the North Celestial Pole region using the RATAN-600 radio telescope at five frequencies in the range 2.3 to 21.7 GHz is described. Sources were chosen from the NVSS catalogue. The flux densities of 171 sources in the Declination range +75 to +88 are presented; typical flux density errors are 5-10 percent including calibration errors. About 20 percent of the sources have flat spectra or a flat component.Comment: 21 pages, 7 figures; to be published in Astronomy and Astrophysics (without last figure with the spectra of the observed sources

Overexpression of Glyoxalase-I in Bovine Endothelial Cells Inhibits Intracellular Advanced Glycation Endproduct Formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

Methylglyoxal (MG), a dicarbonyl compound produced by the fragmentation of triose phosphates, forms advanced glycation endproducts (AGEs) in vitro. Glyoxalase-I catalyzes the conversion of MG to S-D-lactoylglutathione, which in turn is converted to D-lactate by glyoxalase-II. To evaluate directly the effect of glyoxalase-I activity on intracellular AGE formation, GM7373 endothelial cells that stably express human glyoxalase-I were generated. Glyoxalase-I activity in these cells was increased 28-fold compared to neo-transfected control cells (21.80+/-0.1 vs. 0. 76+/-0.02 micromol/min/mg protein, n = 3, P \u3c 0.001). In neo-transfected cells, 30 mM glucose incubation increased MG and D-lactate concentration approximately twofold above 5 MM (35.5+/-5.8 vs. 19.6+/-1.6, P \u3c 0.02, n = 3, and 21.0+/-1.3 vs. 10.0+/-1.2 pmol/ 10(6) cells, n = 3, P \u3c 0.001, respectively). In contrast, in glyoxalase-I-transfected cells, 30 mM glucose incubation did not increase MG concentration at all, while increasing the enzymatic product D-lactate by \u3e 10-fold (18.9+/-3.2 vs. 18.4+/- 5.8, n = 3, P = NS, and 107.1+/-9.0 vs. 9.4+/-0 pmol/10(6) cells, n = 3, P \u3c 0.001, respectively). After exposure to 30 mM glucose, intracellular AGE formation in neo cells was increased 13.6-fold (2.58+/-0.15 vs. 0.19+/-0.03 total absorbance units, n = 3, P \u3c 0.001). Concomitant with increased intracellular AGEs, macromolecular endocytosis by these cells was increased 2.2-fold. Overexpression of glyoxalase-I completely prevented both hyperglycemia-induced AGE formation and increased macromolecular endocytosis

Are Long Term Cryopreservation and Patency of Vein Allograft Truly Achievable?

Despite extensive experimental work, neither the effect of long term cryopreservation on vein graft architecture nor the failure of alloveins due to graft rejection have yet been investigated. Herein, we investigated ultrastructurally: a) the integrity of rabbit jugular veins following 1, 2 and 3 months of cryopreservation; b) the outcome of the three-month cryopreserved vein auto- and allografts after 1 month of implantation in the rabbit carotid artery; and c) the immunologic response to cryopreserved vein allografts with and without seeded autologous endothelium. Prior to implantation, the cryopreserved rabbit veins were well-maintained except for endothelial cell damage. Following implantation, the cryopreserved vein autografts were comparable to fresh veins with a complete endothelial lining. Conversely, only one of the allograft was still patent with features of acute rejection. After seeding with autologous endothelium , these explants failed shortly after surgery. We found absence of endothelium and necrosis of the media components with neutrophil infiltration. Although three months of cryopreservation does not affect vein graft architecture significantly, endothelial cells are damaged irrespective of the time of cryopreservation. Vein autografts promptly healed after one month of implantation at which time a viable endothelial cell lining was restored from the host artery. Conversely, vein allografts, with and without seeded autologous endothelium, failed due to graft rejection. This study highlights that current methods of cryopreservation do not reduce antigenicity of venous allografts significantly

Three Spin Spiky Strings in beta-deformed Background

We study rigidly rotating strings in $\beta$-deformed $AdS_5\times S^5$ background with one spin along AdS$_5$ and two angular momenta along $S^5$. We find the spiky string solutions and present the dispersion relation among various charges in this background. We further generalize the result to the case of four angular momenta along $AdS_5 \times S_{\gamma}^5$.Comment: 12 pages, minor corrections, added references, to appear in JHE

A case of Incontinentia Pigmenti associated with congenital absence of portal vein system and nodular regenerative hyperplasia

Congenital absence of portal vein system (CAPVS) is a rare condition in which portal perfusion is bypassed by portosystemic shunt leading to the development of portal hypertension (PH) or porto‐systemic encephalopathy (PSE). Visceral anomalies and liver cancer can be associated with CAPVS1.Thanks to the advances in imaging, the number of CAPVS cases detected has increased. Incontinentia Pigmenti (IP) (OMIM #308300) also represents a rare condition, characterized by skin, teeth, hair, nails, eyes and central nervous system alterations, due to mutations of NEMO/IKBKG gene. We report on the first case of IP associated with CAPVS and nodular regenerative hyperplasia (NRH) of the liver, in a patient with facial dysmorphisms and speech delay. Although rare, this finding may support the role of NEMO in liver homeostasis

1.4 GHz polarimetric observations of the two fields imaged by the DASI experiment

We present results of polarization observations at 1.4 GHz of the two fields imaged by the DASI experiment ($\alpha = 23^{\rm h} 30^{\rm m}$, $\delta = -55^{\circ}$ and $\alpha = 00^{\rm h} 30^{\rm m}$, $\delta = -55^{\circ}$, respectively). Data were taken with the Australia Telescope Compact Array with 3.4 arcmin resolution and $\sim 0.18$ mJy beam$^{-1}$ sensitivity. The emission is dominated by point sources and we do not find evidence for diffuse synchrotron radiation even after source subtraction. This allows to estimate an upper limit of the diffuse polarized emission. The extrapolation to 30 GHz suggests that the synchrotron radiation is lower than the polarized signal measured by the DASI experiment by at least 2 orders of magnitude. This further supports the conclusions drawn by the DASI team itself about the negligible Galactic foreground contamination in their data set, improving by a factor $\sim 5$ the upper limit estimated by Leitch et al. (2005). The dominant point source emission allows us to estimate the contamination of the CMB by extragalactic foregrounds. We computed the power spectrum of their contribution and its extrapolation to 30 GHz provides a framework where the CMB signal should dominate. However, our results do not match the conclusions of the DASI team about the negligibility of point source contamination, suggesting to take into account a source subtraction from the DASI data.Comment: 7 pages, six figures, submitted to MNRA

Probing for Invisible Higgs Decays with Global Fits

We demonstrate by performing a global fit on Higgs signal strength data that large invisible branching ratios Br_{inv} for a Standard Model (SM) Higgs particle are currently consistent with the experimental hints of a scalar resonance at the mass scale m_h ~ 124 GeV. For this mass scale, we find Br_{inv} < 0.64 (95 % CL) from a global fit to individual channel signal strengths supplied by ATLAS, CMS and the Tevatron collaborations. Novel tests that can be used to improve the prospects of experimentally discovering the existence of a Br_{inv} with future data are proposed. These tests are based on the combination of all visible channel Higgs signal strengths, and allow us to examine the required reduction in experimental and theoretical errors in this data that would allow a more significantly bounded invisible branching ratio to be experimentally supported. We examine in some detail how our conclusions and method are affected when a scalar resonance at this mass scale has couplings deviating from the SM ones.Comment: 32pp, 15 figures v2: JHEP version, ref added & comment added after Eq.