5,223 research outputs found
Antioxidant and Angiotensin I-Converting Enzyme (ACE) Inhibitory Peptides Obtained from Alcalase Protein Hydrolysate Fractions of Hemp (Cannabis sativa L.) Bran
Proteins from hemp bran (HPB), a byproduct of the hemp seed food-processing chain, were chemically extracted, hydrolyzed by Alcalase, and separated by membrane ultrafiltration into four fractions (MW <1, 1-3, 3-5, and >5 kDa). The antioxidant and antihypertensive properties of the initial extract and the fractions were evaluated by in vitro assays for their ability to scavenge radical species, bind with metal ions, reduce ferric ions, and inhibit angiotensin-converting enzyme (ACE) activity. Bioactive peptides were identified by high-resolution mass spectrometry and sequence comparison with BIOPEP and BioPep DB databases. The hydrolysate was strongly antioxidant and ACE-inhibiting; the most bioactive peptides were further concentrated by ultrafiltration. Of the 239 peptides identified, 47 (12 antioxidant and 35 ACE-inhibitory) exhibited structural features correlated with the specific bioactivity. These results highlight the promise of hydrolysate and size-based HPB fractions as natural functional ingredients for the food or pharmaceutical industry
Production of Scalar Higgs Bosons Associated with Boson at the CERN LHC in the MSSM
We investigate the associated production of a scalar Higgs boson ( or
) with boson in the minimal supersymmetric extension of the standard
model (MSSM) at the CERN Large Hadron Collider (LHC), including the
contributions from annihilation at the tree level and gluon fusion
via quark and squark loops. We quantitatively analyze the total cross sections
in the mSUGRA scenario. For the production of associated with , we
find that in most of the parameter regions, the contributions from initial
and are at a level of one percent of the total cross section
and therefore almost insignificant. For the production of associated with
, the contributions from channel can be much larger than those
from light quark initial states. Especially for large , the
increment can reach about one order of magnitude. Thus, when considering the
associated production of and at the LHC, the contributions from
annihilation should be taken into account seriously.Comment: 19 pages, 8 figures, RevTeX4; one reference added, minor changes,
conclusion unchanged; Journal-ref adde
Tako-Tsubo cardiomyopathy in an older woman with hyperkinetic delirium
Tako-Tsubo syndrome is cardiological condition, mainly affecting post-menopausal women, that mimics an acute heart attack, because a similar clinical presentation, ECG changes and altered laboratory tests. There is general consensus that the common etiology is a sudden and strong emotional or physical stress. We report here the case of 80-yearold woman who developed a Tako-Tsubo syndrome during an episode of hyperkinetic delirium. Delirium is an acute, transient, usually reversible neuropsychiatric syndrome, considered a serious and stressful condition in older patients admitted to both medical and surgical setting. This clinical case expands our knowledge on the negative consequence of delirium in hospitalized patients and describes an additional risk factor for Tako-Tsubo syndrome in older people
Scenarios about the long-time damage of silicon as material and detectors operating beyond LHC collider conditions
For the new hadron collider LHC and some of its updates in luminosity and
energy, as SLHC and VLHC, the silicon detectors could represent an important
option, especially for the tracking system and calorimetry. The main goal of
this paper is to analyse the expected long-time degradation in the bulk of the
silicon as material and for silicon detectors, in continuous radiation field,
in these hostile conditions. The behaviour of silicon in relation to various
scenarios for upgrade in energy and luminosity is discussed in the frame a
phenomenological model developed previously by the authors. Different silicon
material parameters resulting from different technologies are considered to
evaluate what materials are harder to radiation and consequently could minimise
the degradation of device parameters in conditions of continuous long time
operation.Comment: submitted to Physica Scripta Work in the frame of CERN RD-50
Collaboratio
On the Angular Resolution of the AGILE gamma-ray imaging detector
We present a study of the Angular Resolution of the AGILE gamma-ray imaging
detector (GRID) that is operational in space since April 2007. The AGILE
instrument is made of an array of 12 planes each equipped with a Tungsten
converter and Silicon micros trip detectors and is sensitive in the energy
range 50 MeV - 10 GeV. Among the space instruments devoted to gamma-ray
astrophysics, AGILE uniquely exploits an analog readout system with dedicated
electronics coupled with Silicon detectors. We show the results of Monte Carlo
simulations carried out to reproduce the gamma-ray detection by the GRID, and
we compare them to in-flight data. We use the Crab (pulsar + Nebula) system for
discussion of real data performance, since its E^{-2} energy spectrum is
representative of the majority of gamma-ray sources. For Crab-like spectrum
sources, the GRID angular resolution (FWHM of ~4deg at 100 MeV; ~0.8deg at 1
GeV; ~0.9deg integrating the full energy band from 100 MeV to tens of GeV) is
stable across a large field of view, being characterized by a flat response up
to 30deg off-axis. A comparison of the angular resolution obtained by the two
operational gamma-ray instruments, AGILE-GRID and Fermi-LAT, is interesting in
view of future gamma-ray missions, that are currently under study. The two
instruments exploit different detector configurations affecting the angular
resolution: the former being optimized in the readout and track reconstruction
especially in the low-energy band, the latter in terms of converter thickness
and power consumption. We show that, despite these differences, the angular
resolution of both instruments is very similar between 100 MeV and a few GeV.Comment: 19 pages, 8 figures, accepted for publication in Ap
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