8 research outputs found
Divergent Construction of Pyrazoles via Michael Addition of N‑Arylhydrazones to 1,2-Diaza-1,3-dienes
partially_open4noThe base (NaH)-promoted Michael addition of
N-arylhydrazones (AHs) with 1,2-diaza-1,3-dienes (DDs)
produces unprecedented β-azohydrazone adducts. Strategically,
the use of AHs as acyl anion equivalents (d1 synthon)
and DDs as α-electrophiles (a2 synthon) of carbonyl
compounds open the way to two important classes of pyrazole
compounds.embargoed_20160409Serena mantenuto; Fabio Mantellini; Orazio Attanasi; Gianfranco FaviMantenuto, Serena; Mantellini, Fabio; Attanasi, ORAZIO ANTONIO; Favi, Gianfranc
Divergent Construction of Pyrazoles via Michael Addition of <i>N</i>‑Arylhydrazones to 1,2-Diaza-1,3-dienes
The base (NaH)-promoted Michael addition
of <i>N</i>-arylhydrazones
(AHs) with 1,2-diaza-1,3-dienes (DDs) produces unprecedented β-azohydrazone
adducts. Strategically, the use of AHs as acyl anion equivalents (<i>d</i><sup>1</sup> synthon) and DDs as α-electrophiles
(<i>a</i><sup>2</sup> synthon) of carbonyl compounds open
the way to two important classes of pyrazole compounds
Useful Access to Uncommon Thiazolo[3,2‑<i>a</i>]indoles
A practical and environmentally
benign protocol for the
assembly
of poly substituted-thiazolo[3,2-a]indoles from 3-alkylated
indoline-2-thiones and 2-halo-ketones has been developed. This metal-free
approach consists in a complete chemo/regioselective formal [3 + 2]
annulation that occurs in air, at 60 °C, and in water as the
sole reaction medium. The opportunity to vary the substitution pattern
up to six different positions, odorless manipulation of sulfurylated
compounds, very easy product isolation, and mild reaction conditions
are the main synthetic features of this method. The scaled-up experiment
and the successive transformations of the products further demonstrate
the utility of this chemistry
Synthesis of Densely Functionalized 3a,4-Dihydro‑1<i>H</i>‑Pyrrolo[1,2‑<i>b</i>]Pyrazoles via Base Mediated Domino Reaction of Vinyl Malononitriles with 1,2-Diaza-1,3-dienes
A domino reaction of vinyl malononitriles (VMs) with 1,2-diaza-1,3-dienes (DDs) produce unprecedented 3a,4-dihydro-1<i>H</i>-pyrrolo[1,2-<i>b</i>]pyrazole systems in a chemo-, regio-, and stereoselective fashion. This base promoted (DIPEA) one-pot transformation involving multiple steps constructs one new C–C bond, two C–N bonds, and two new fused heterocyclic rings with total atom economy
Tandem Aza-Wittig/Carbodiimide-Mediated Annulation Applicable to 1,2-Diaza-1,3-dienes for the One-Pot Synthesis of Fully Substituted 1,2-Diaminoimidazoles
One-pot sequential aza-Michael, Staudinger, and aza-Wittig
reactions
on 1,2-diaza-1,2-dienes (DDs) can afford fully substituted 1,2-diaminoimidazoles.
A plausible mechanism for the imidazole core formation involving an
intramolecular ring closure of the carbodiimide-derived phosphazene
intermediate is given. The reported strategy has sufficient flexibility
to allow substituted 1,2-diaminoimidazoles with orthogonal nitrogen-protective
groups to be generated from a variety of heterocumulene moieties linked
to the DDs skeleton
Powerful Approach to Heterocyclic Skeletal Diversity by Sequential Three-Component Reaction of Amines, Isothiocyanates, and 1,2-Diaza-1,3-dienes
By highly efficient, one-pot, three-component reactions,
combining
one set of 1,2-diaza-1,3-dienes (DDs), primary amines, and isothiocyanates
in a different sequential order of addition, heterocyclic skeletal
diversity can be achieved. The key feature discriminating the different
heterocyclic core formation is the availability of the <i>N</i> or <i>S</i> heteronucleophile to give the first Michael
addition step affording regioselective substituted 2-thiohydantoins
or 2-iminothiazolidinones. The hydrazone or enehydrazino side chain
at the 5-position of both heterocycles represents a valuable functionality
to reach novel 5-hydroxyethylidene derivatives difficult to obtain
by other methods
Interceptive [4 + 1] Annulation of in Situ Generated 1,2-Diaza-1,3-dienes with Diazo Esters: Direct Access to Substituted Mono‑, Bi‑, and Tricyclic 4,5-Dihydropyrazoles
In situ derived acyclic and cyclic
1,2-diaza-1,3-dienes (DDs) were
engaged in interceptive [4 + 1] annulation strategy with diazo esters
(DEs). The catalytic activity of inexpensive copperÂ(II) chloride allows
the direct synthesis of mono-, bi-, and tricyclic 4,5-dihydropyrazole-5-carboxylic
acid derivatives in a process that circumvents the use of an anhydrous
and inert atmosphere
Divergent Approach to Thiazolylidene Derivatives: A Perspective on the Synthesis of a Heterocyclic Skeleton from β‑Amidothioamides Reactivity
Herein we report a domino protocol
able to reach regioselectively
thiazolylidene systems by combining the reactive peculiarities of
both β-amidothioamides (ATAs) and 1,2-diaza-1,3-dienes (DDs).
Depending on the reaction conditions and/or the nature of the residue
at C4 of the heterodiene system, ATAs can act as hetero-mononucleophiles
or hetero-dinucleophiles in the diversified thiazolylidene ring assembly