Declaration of use and appropriate use of reporting guidelines in high-impact rehabilitation journals is limited: a meta-research study

Objectives: The main aims of this metaresearch study conducted among high-impact rehabilitation journals were: 1) to evaluate if the use of reporting guidelines (RGs) was declared and 2) to categorize the declared use as appropriate or inappropriate. Study Design and Setting: Cross-sectional analysis of a random sample of 200 studies published in the period 2010\u20132019 in five generic rehabilitation journals with the highest 5-year impact factor. Randomized controlled trials, systematic reviews, observational studies, and diagnostic studies were included. Prevalence with 95% confidence intervals (CIs) was estimated for the main outcomes. Results: Among the 200 selected studies, 17.5% (95% CI: 12.2\u201322.8%) declared using RGs. Among these studies, 48.6% (95% CI: 32\u201365.1%) declared an appropriate use. There was an increasing trend over time for authors to report the use of RGs (OR: 1.31; 95% CI: 1.13\u20131.53). Systematic reviews (n = 54) reported more frequently the use of RGs than other study designs (35.2%). Conclusion: In high-impact rehabilitation journals, a small minority of article authors declared the use of RGs. In approximately half of these studies, RGs were used inappropriately. There is an urgent need to improve the use of RGs in this field of research

Declaration of use and appropriate use of reporting guidelines in high-impact rehabilitation journals is limited: a meta-research study

Objectives: The main aims of this metaresearch study conducted among high-impact rehabilitation journals were: 1) to evaluate if the use of reporting guidelines (RGs) was declared and 2) to categorize the declared use as appropriate or inappropriate. Study Design and Setting: Cross-sectional analysis of a random sample of 200 studies published in the period 2010–2019 in five generic rehabilitation journals with the highest 5-year impact factor. Randomized controlled trials, systematic reviews, observational studies, and diagnostic studies were included. Prevalence with 95% confidence intervals (CIs) was estimated for the main outcomes. Results: Among the 200 selected studies, 17.5% (95% CI: 12.2–22.8%) declared using RGs. Among these studies, 48.6% (95% CI: 32–65.1%) declared an appropriate use. There was an increasing trend over time for authors to report the use of RGs (OR: 1.31; 95% CI: 1.13–1.53). Systematic reviews (n = 54) reported more frequently the use of RGs than other study designs (35.2%). Conclusion: In high-impact rehabilitation journals, a small minority of article authors declared the use of RGs. In approximately half of these studies, RGs were used inappropriately. There is an urgent need to improve the use of RGs in this field of research

Completeness of Reporting Is Suboptimal in Randomized Controlled Trials Published in Rehabilitation Journals, With Trials With Low Risk of Bias Displaying Better Reporting: A Meta-research Study

Objective Primary: To evaluate the completeness of reporting of randomized controlled trials (RCTs) published in rehabilitation journals through the evaluation of the adherence to the Consolidated Standards of Reporting Trials (CONSORT) checklist and investigate the relationship between reporting and risk of bias (ROB). Secondary: To study the association between completeness of reporting and the characteristics of studies and journals. Data Sources A random sample of 200 RCTs published between 2011 and 2020 in 68 rehabilitation journals indexed under the “rehabilitation” category in the InCites Journal Citation Report. Study Selection One reviewer evaluated the completeness of reporting operationalized as the adherence to the CONSORT checklist. Two independent reviewers evaluated the ROB using the Cochrane risk-of-bias 2.0 tool. Data Extraction Overall adherence and adherence to each CONSORT section were calculated. Regression analyses investigated the association between completeness of reporting, ROB, and other characteristics (quartile range, publication modalities, study protocol registration). Data Synthesis The mean overall CONSORT adherence across studies was 65%. Studies with high ROB have less adherence than those with low ROB (−5.5%; CI, −10.9 to 0.0). There was a 10.2% (% CI, 6.2-14.3) increase in adherence if the RCT protocol was registered. Studies published in first quartile journals displayed an overall adherence of 11.7% (% CI 17.1-6.4) higher than those published in the fourth quartile. Conclusions Reporting completeness is still suboptimal and is associated with ROB, journal impact ranking, and registration of the study protocol. Trial authors should improve adherence to the CONSORT guideline, and journal editors should adopt new strategies to improve the reporting

Completeness of Reporting Is Suboptimal in Randomized Controlled Trials Published in Rehabilitation Journals, With Trials With Low Risk of Bias Displaying Better Reporting: A Meta-research Study

Abstract Objective: Primary: To evaluate the completeness of reporting of randomized controlled trials (RCTs) published in rehabilitation journals through the evaluation of the adherence to the Consolidated Standards of Reporting Trials (CONSORT) checklist and investigate the relationship between reporting and risk of bias (ROB). Secondary: To study the association between completeness of reporting and the characteristics of studies and journals. Data sources: A random sample of 200 RCTs published between 2011 and 2020 in 68 rehabilitation journals indexed under the "rehabilitation" category in the InCites Journal Citation Report. Study selection: One reviewer evaluated the completeness of reporting operationalized as the adherence to the CONSORT checklist. Two independent reviewers evaluated the ROB using the Cochrane risk-of-bias 2.0 tool. Data extraction: Overall adherence and adherence to each CONSORT section were calculated. Regression analyses investigated the association between completeness of reporting, ROB, and other characteristics (quartile range, publication modalities, study protocol registration). Data synthesis: The mean overall CONSORT adherence across studies was 65%. Studies with high ROB have less adherence than those with low ROB (-5.5%; CI, -10.9 to 0.0). There was a 10.2% (% CI, 6.2-14.3) increase in adherence if the RCT protocol was registered. Studies published in first quartile journals displayed an overall adherence of 11.7% (% CI 17.1-6.4) higher than those published in the fourth quartile. Conclusions: Reporting completeness is still suboptimal and is associated with ROB, journal impact ranking, and registration of the study protocol. Trial authors should improve adherence to the CONSORT guideline, and journal editors should adopt new strategies to improve the reporting

Thermal behaviour of malonic acid, sodium malonate and its compounds with some bivalent transition metal ions

Characterization, thermal stability and thermal decomposition of transition metal malonates, MCH(2)C(2)O(4)center dot nH(2)O (M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II)), as well as, the thermal behaviour of malonic acid (C(3)H(4)O(4)) and its sodium Salt (Na(2)CH(2)C(2)O(4)center dot H(2)O) were investigated employing Simultaneous thermogravimetry and differential thermal analysis (TG-DTA), differential scanning calorimetry (DSC). infrared spectroscopy, TG-FTIR system, elemental analysis and complexometry. The dehydration, as well as, the thermal decomposition of the anhydrous compounds Occurs in a single step. For the sodium malonate the final residue up to 700 C is sodium carbonate, while the transition metal malonates the final residue up to 335 C (Mn), 400 C (Fe), 340 degrees C (Co), 350 C (Ni), 520 C (Cu) and 450 C (Zn) is Mn(3)O(4), Fe(2)O(3), Co(3)O(4). NiO, CuO and ZnO, respectively. The results also provided information concerning the ligand's denticity, thermal behaviour and identification of some gaseous products evolved during the thermal decomposition of these compounds. (C) 2009 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

Characterization and Microbiological Application of Ciprofloxacin Loaded in Natural Rubber Latex Membranes

Natural rubber latex (NRL) from Hevea brasiliensis presents interesting characteristics in biomedical research due to its ability to stimulate angiogenesis, cellular adhesion and formation of extracellular matrix. A broad spectrum antibacterial agent used in skin infection is Ciprofloxacin hydrochloride (CIP). It is a fluoroquinolone employed to treat different bacterial infections caused by gram-positive and gram-negative microorganism. The aim of the present study is to promove the CIP incorporation on the natural material due to develop a biomaterial which could accelerate tissue repair and control wounds infection. The biomaterial characterization was made through several technics. The compound presence on the membrane was observed by Scanning Electron Microscopy technique, which shown crystals merged on the material surface. Through X-Ray Powder Diffraction technic was possible to notice the absence of crystallinity (amorphous structure) in the drug-loaded NRL membrane indicating that the drug is molecularly dispersed within the NRL. Besides that, there are no molecular interaction between drug and NRL showed by Fourier Transform Infrared Spectroscopy neither Raman spectroscopy. Additionally, there were no significant changes in the NRL pyrolysis profile when the drug was added, indicating weak interaction between both compounds, as presented by Derivative Thermogravimetric Analysis assay. Comparing the mechanical properties, both samples (with and without CIP) had a similar behavior. Thus, is possible to presume the material preserved enough elasticity to medical application. Furthermore, antimicrobial assay proved that CIP activity was preserved after its incorporation to the NRL. It allows us to conclude that the material has potential application in infected wound treatment