2 research outputs found
Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization
The frequency of triplet gestation is low in
humans, estimated at 1:6400 deliveries. Monochorionic
gestations represent a subpopulation of approximately
10% of these triplet pregnancies. Hypertensive
complications are known to occur with greater frequency
in the context of multiple gestation. In this report we
describe microscopic placental changes associated with
pre-eclampsia and proteinuria in the setting of an
uncommon monochorionic-triamniotic triplet pregnancy
achieved via in vitro fertilization. Histologic features
observed in this case include placental stromal fibrosis
and increased syncytial nodularity (Tenney-Parker
change). In this triplet delivery resulting from two
consecutive fissions of a single embryo, chorion and
amnion configuration are also characterized with a
review of the literature discussing the potential
relationship between in vitro culture conditions and
monozygotic multiple gestation