12 research outputs found

    Synthesis of some biologically important fluorinated 3-chlorochromones and 1,5-benzothiazepines as antimicrobial and antifungal agents

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    1267-1270A series of synthetic 3-chlorochromones and 1,5-benzo­thiazepines have been synthesized and evaluated for their antimicrobial and antifungal activity against Gram +ve and Gram -ve microorganisms. In these series the chemical transformation of chalcones to respective 3-chlorochromones and 1,5-benzothia­zepines by using DMSO/CuCl2 and 2-aminothiophenol respective­ly has been carried out. Compounds synthesized have been screened for antibacterial activity using Gentamycin and Cefixime and for antifungal activity using Ketoconazole as reference drugs

    Chromone: A valid scaffold in medicinal chemistry

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    Chromones are a group of naturally occurring compounds that are ubiquitous in nature, especially in plants. The word chromone is derived from the Greek word chroma, meaning “color”, which point out that many chromone derivatives can exhibit a diversity of colors.This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants
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