51 research outputs found
COVID-19 and acute kidney injury; a case report
Although there is no definitive evidence that coronavirus disease 2019 (COVID-19) affects the kidneys adversely, amongst those who develop severe COVID-19 infection and require hospitalization, acute kidney injury (AKI) was reported. Here, we report the clinical outcome associated with AKI in a 32-year-old man with confirmed COVID-19 infection with no prior history of renal malfunction. The AKI was identified during intensive care unit (ICU) course with the median creatinine and blood urea nitrogen values of 3.1 mg/dL (normal value: 0.6-1.2 mg/dL) and 145 mg/dL (normal value:15-45 mg/dL), respectively. Renal function of patients hospitalized with COVID-19 infection needs to be monitored regularly to intervene as early as possible and to prevent the development of AKI and further kidney complications
Potential role of saffron and its components on miRNA levels in various disorders, a comprehensive review
The potential therapeutic benefits of saffron and its active constituents have been investigated for the treatment of numerous illnesses. In this review, the impacts of saffron and its essential components on the levels of microRNAs (miRNAs) in different diseases have been delineated. Relevant articles were obtained through databases such as PubMed, Web of Sciences, Scopus, and Google Scholar up to the end of November 2022. miRNA expression has been altered by saffron and its active substances (crocin, crocetin, and safranal) which has been of great advantage in treating diseases such as cardiovascular, type 2 diabetes, cancers, gastrointestinal and liver disorders, central and peripheral nervous system disorders, asthma, osteoarthritis, ischemic-reperfusion induced injury conditions, and renal disorder. This study uncovered the potential restorative advantages of saffron and its derivatives, in miRNA imbalances in a variety of diseases
Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases
Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications.
This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its
correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due
to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 + 9.18 years
were enrolled in this cross sectional study. Thirty healthymen were selected as controls. Lung function parameters
were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls.
Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 + 0.76 L
(58.98%+17.51% predicted). The mean serum hs-CRP was 9.4+6.78 SD and 3.9+1.92 SDmg/L in the cases
and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between
the serum hs-CRP and FEV1 levels (p ¼ .01). The serum hs-CRP levels were also correlated with Global Initiative
for ChronicObstructive Lung disease (GOLD) stages (r ¼ .45, p < .001). Conclusions:Our findings suggest that
the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease
severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning
Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease
Objectives: Chronic obstructive pulmonary disease (COPD) is one of the main late complications
of sulfur mustard poisoning. The aim of this study was to evaluate serum levels of interleukin
(IL)-6 in war veterans with pulmonary complications of sulfur mustard poisoning and their correlation
with severity of airways disease.
Methods: Fifty consecutive patients with sulfur mustard poisoning and stable COPD, and of mean
age 46.3 ± 9.18 years were enrolled in this study. Thirty healthy men were selected as controls
and matched to cases by age and body mass index. Spirometry, arterial blood gas, six-minute
walk test, BODE (body mass index, obstruction, dyspnea, and exercise capacity), and St George’s
Respiratory Questionnaire about quality of life were evaluated. Serum IL-6 was measured in
both patient and control groups.
Results: Fifty-four percent of patients had moderate COPD. Mean serum IL-6 levels were
15.01 ± standard deviation (SD) 0.61 pg/dL and 4.59 ± 3.40 pg/dL in the case and control groups,
respectively (P = 0.03). There was a significant correlation between IL-6 levels and Global
Initiative for Chronic Obstructive Lung Disease stage (r = 0.25, P = 0.04) and between IL-6
and BODE index (r = 0.38, P = 0.01). There was also a significant negative correlation between
serum IL-6 and forced expiratory volume in one second (FEV1, r = −0.36, P = 0.016).
Conclusion: Our findings suggest that serum IL-6 is increased in patients with sulfur mustard
poisoning and COPD, and may have a direct association with airflow limitation
A genetic variant in CDKN2A/2B locus was associated with poor prognosis in patients with 1 esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is among the leading causes of cancer related death. Despite extensive efforts in identifying valid cancer prognostic biomarkers, only a very small number of markers have been identified. Several genetic variants in the 9p21 region have been identified that are associated with the risk of multiple cancers. Here, we explored the association of two genetic variants in the 9p21 region, CDKN2A/B, rs10811661 and rs1333049 for the first time in 273 subjects with, or without ESCC. We observed that patients with ESCC had a higher frequency of a TT genotype for rs10811661 than individuals in the control group, and this polymorphism was also associated with tumor size. Moreover, a CC genotype for the rs1333049 polymorphism was associated with a reduced OS of patients with ESCC. In particular, patients with a CC (rs1333049) genotype had a significantly shorter OS (CC genotype: 34.5±8.9 months vs. CG+GG: 47.7±5.9 months; p value= 0.03). We have also shown the association of a novel genetic variant in CDKN2B gene with clinical outcome of ESCC patients. Further investigations are warranted in a larger population to explore the value of emerging markers as a risk stratification marker in ESCC.
Key word: Esophageal squamous cell carcinoma, risk marker, CDKN2A/B, polymorphis
Pulmonary Artery Agenesis with Bronchial Asthma
Unilateral Pulmonary Artery Agenesis (UPAA) is a rare congenital anomaly during the 4 th week of gestational age. It is defined as an absence of pulmonary parenchyma and its supporting artery. A 9-year-old girl was admitted to our hospital because of chronic cough. Chest examination showed a decrement in lung sound of right hemi-thorax with expiratory wheeze. Chest radiography (CXR) revealed a semi-opaque right hemi-thorax. Chest CT with intra-venous contrast demonstrated absence of the right pulmonary artery and lung parenchyma with hyper-inflated left lung and dextro-position of mediastinum. This case emphasizes that in patients with respiratory compliant and chronic cough CXR must be done to rule out similar diagnosis other than asthma.
Pulmonary Artery Agenesis with Bronchial Asthma
Unilateral Pulmonary Artery Agenesis (UPAA) is a rare congenital anomaly during the 4 th week of gestational age. It is defined as an absence of pulmonary parenchyma and its supporting artery. A 9-year-old girl was admitted to our hospital because of chronic cough. Chest examination showed a decrement in lung sound of right hemi-thorax with expiratory wheeze. Chest radiography (CXR) revealed a semi-opaque right hemi-thorax. Chest CT with intra-venous contrast demonstrated absence of the right pulmonary artery and lung parenchyma with hyper-inflated left lung and dextro-position of mediastinum. This case emphasizes that in patients with respiratory compliant and chronic cough CXR must be done to rule out similar diagnosis other than asthma.
The Evidence of Hyperinflation on Chest X Ray and its Correlation with Air Flow Obstruction in COPD Patients
Introduction: According to the latest statistical and epidemiological studies, COPD will become the fourth leading cause of death in 2030 worldwide. Scientists are studying on methods to diagnose COPD in the patients in early stages, because it is a curable and preventable disease in early stages. In this study, evidences of hyperinflation on CXR of COPD patients were compared with pulmonary function test (PFT) finding. Materials and Methods: This cross-sectional study was done on 100 patients who were referred to the pulmonary clinic with symptoms of chronic cough and dyspnea. After taking history and performing physical examination, demographic information, history of smoking and bakery and frequency of exacerbations were recorded. Standard spirometry was performed and the severity of COPD was determined by GOLD (Global initiative for chronic Obstructive Lung Disease) staging. Additionally, they underwent CXR examination (PA and lateral). Collected data were analyzed in SPSS ver. 18. Results: In this study, there were 79 male and 21 female. .. . . The patients, 64% of whom were urban and 36% were rural dwellers. There was significant correlation between FEF50%predict with sterno-diafragmatic angle and retro-sternal lucency (p=0.01, r=-0.26 and p=0.01, r=-0.25 respectively). Also there were significant correlations between the FEV1/FVC with retro-sternal lucency (p=0.006, r=-0.27) and FEV1%predict with sterno-diaphragmatic angle (p=0.002, r=-0.31). Conclusion: The study showed some evidences of lung hyperinflation on CXR which significantly associated with PFT parameters. Sterno-diaphragmatic angle and retro-sternal lucency can be used to predict the severity of airway obstruction in patients with COPD, although the CXR finding cannot be substituted for PFT and CT data.
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