5 research outputs found
Thermodynamics of a μ‑oxo Dicopper(II) Complex for Hydrogen Atom Abstraction
The
mono-μ-hydroxo complex {[CuÂ(tmpa)]<sub>2</sub>-(μ-OH)}<sup>3+</sup> (<b>1</b>) can undergo reversible deprotonation at
−30 °C to yield {[CuÂ(tmpa)]<sub>2</sub>-(μ-O)}<sup>2+</sup> (<b>2</b>). This species is basic with a p<i>K</i><sub>a</sub> of 24.3. <b>2</b> is competent for concerted
proton–electron transfer from TEMPOH, but is an intrinsically
poor hydrogen atom abstractor (BDFEÂ(OH) of 77.2 kcal/mol) based on
kinetic and thermodynamic analyses. Nonetheless, DFT calculations
experimentally calibrated against <b>2</b> reveal that [Cu<sub>2</sub>O]<sup>2+</sup> is likely thermodynamically viable in copper-dependent
methane monoxygenase enzymes
Thermodynamics of a μ‑oxo Dicopper(II) Complex for Hydrogen Atom Abstraction
The
mono-μ-hydroxo complex {[CuÂ(tmpa)]<sub>2</sub>-(μ-OH)}<sup>3+</sup> (<b>1</b>) can undergo reversible deprotonation at
−30 °C to yield {[CuÂ(tmpa)]<sub>2</sub>-(μ-O)}<sup>2+</sup> (<b>2</b>). This species is basic with a p<i>K</i><sub>a</sub> of 24.3. <b>2</b> is competent for concerted
proton–electron transfer from TEMPOH, but is an intrinsically
poor hydrogen atom abstractor (BDFEÂ(OH) of 77.2 kcal/mol) based on
kinetic and thermodynamic analyses. Nonetheless, DFT calculations
experimentally calibrated against <b>2</b> reveal that [Cu<sub>2</sub>O]<sup>2+</sup> is likely thermodynamically viable in copper-dependent
methane monoxygenase enzymes
Pedigree of a consanguineous Pakistani family segregating an autosomal recessive form of a novel type of ectodermal dysplasia.
<p>Circles and squares represent females and males, respectively. Clear symbols represent unaffected individuals while filled symbols represent affected individuals. Symbols with asterisk represent DNA samples available for the molecular analysis.</p
Ideogram of chromosome 18 displaying positions of the functional genes along the linkage interval (Chr18p11.32-p11.31 on GRCH37/hg19 assembly) of 3.03 Mb identified in the family.
<p>Ideogram of chromosome 18 displaying positions of the functional genes along the linkage interval (Chr18p11.32-p11.31 on GRCH37/hg19 assembly) of 3.03 Mb identified in the family.</p
Two-point LOD score between ED syndrome and SNP markers on chromosome 18p11.32-p11.31.
<p><b>a</b> Physical positions of the SNPs are according to the dbSNP132 (<a href="http://genome.ucsc.edu/cgi-bin/hgGateway" target="_blank">http://genome.ucsc.edu/cgi-bin/hgGateway</a>)</p><p><b>b</b> Recombination fraction.</p><p>Two-point LOD score between ED syndrome and SNP markers on chromosome 18p11.32-p11.31.</p