Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N-substituted Naphthylethylimidazoline

A number of organosilicon and organogermanium derivatives and some related compounds including the N-substituted. 2-[1-naphthylmethyl]-2-imidazoline and 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been prepared and the toxicity of some compounds have been determined in mice. In this paper we report the synthesis and the evaluation of the pharmacological activity of new organosilicon and organogermanium, compounds such as sila- and germadithioacetals derived from N-substituted naphthylimidazolne

Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds

Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds

A Review on the Radioprotective Activity of organogermanium and Organosilicon Compounds

The present review describes the work carried out during the last 20 years in the field of the radioprotective activity and toxicity of several classes of organosilicon and organogermanium compounds (i.e. metallathiazolidines, metalladithioacetals, metallatranes and germathianes)

Synthèse et évaluation de nouveaux dérivés organiques et organométalliques contre les effets des rayonnements ionisants

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Etude et application de nouveaux composés organiques organosiliciés - germaniés, - phosphorés et - séleniés en radioprotection chimique

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Synthèse et évaluation de nouveaux composés organiques et phosphorés contre les effets des rayonnements ionisants (étude de leur mécanisme d action in vitro)

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF