Supplemental material- The integration of Coxiella burnetii PCR testing in serum into the diagnostic algori

Supplemental materials for a study entitled:"The integration of Coxiella burnetii PCR testing in serum into the diagnostic algorithm of suspected acute Q fever in an endemic setting". accepted for publication in the Journal of Clinical Microbiology (JCM01703-23R2) </p

The accuracy of clinical prediction of prognosis for patients admitted with sepsis to internal medicine departments

<div><p></p><p><b>Introduction</b> Prognosis estimation offered by physicians for patients inflicted by sepsis on their admission to Internal Medicine (IM) departments is considered a challenge. Early prognosis estimation is critical and determines the intensity of treatment offered. The accuracy of prognosis estimation made by physicians has previously been investigated mainly among intensive care physicians and oncologists.</p><p><b>Objective</b> To ascertain the accuracy of prognosis prediction made by internists for septic patients on admission to IM departments.</p><p><b>Methods</b> Physicians were asked to estimate the prognosis of every patient identified to have sepsis on admission. Their intuitive assessment of prognosis was incorporated into the patients’ electronic medical record. Survival follow-up was recorded until death or for at least 2 years. Later we compared survival with physicians’ prognosis estimations.</p><p><b>Results</b> Prognosis estimation was recorded for 1,073 consecutive septic patients admitted throughout the years 2008–2009 to IM departments. The mean age of patients was 74.7 ± 16.1 years. A total of 42.4% were suspected to have pneumonia, and 65.4% died during a mean follow-up time of 661.1 ± 612.3 days. Almost half of the patients classified to have good prognosis survived compared to 14.9% and 4.9% of those with intermediate and bad prognosis estimation, respectively (P < 0.001).</p><p><b>Conclusion</b> Internists can discriminate well between septic patients with good, intermediate, and bad prognosis.</p><p></p><p>Key Messages</p><p></p><p>Many patients suffering from sepsis are treated at general medical departments.</p><p></p><p></p><p>Good estimation of the severity of disease upon admission is critical for decision-making regarding treatment.</p><p></p><p></p><p>Internists including junior staff could discriminate well between patients with different degrees of disease severity of sepsis.</p><p></p><p></p><p></p></div

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia

Abstract We looked for predicting factors for the detection of infectious foci on 18F-fluorodeoxyglucose-positron emission tomography in combination with computed tomography (FDG PET/CT) among patients with Staphylococcus aureus bacteremia (SAB) who participated in an interventional study that was conducted at Rambam Health Care Campus, between July 1, 2015 and February 1, 2019. The primary outcome was an infectious focus detected by FDG PET/CT. Independent predictors for detection of focal infection were identified using univariate followed by a logistic regression multivariate analysis. We included 149 patients with 151 separate episodes of SAB who underwent FDG-PET/CT. Focal infections were detected in 107 patients (70.8%). Independent predictors for focal infection detection were community acquisition of bacteremia with odds ratio (OR) 3.03 [95% confidence interval (CI) 1.04–8.77], p-0.042 and C reactive protein (CRP) with OR 1.09 [95% CI 1.04–1.14], p < 0.001. Primary bacteremia was inversely associated with focal infection detection with OR 0.27 [0.10–0.69], p = 0.007, as were the pre-scan blood glucose levels OR 0.9 [0.98–0.99], p-0.004. The latter stayed significant in the subgroup of patients with diabetes mellitus. To conclude, patients with community-acquired bacteremia or high CRP levels should be carefully investigated for focal infection. Patients who present with primary bacteremia seem to be at low risk for focal infection

Risk factors for functional decline among survivors of Gram-negative bloodstream infection: A prospective cohort study

To identify risk factors for functional decline after hospitalization for Gram-negative bacteremia

Seven versus fourteen Days of Antibiotic Therapy for uncomplicated Gram-negative Bacteremia: a Non-inferiority Randomized Controlled Trial

Gram-negative bacteremia is a major cause of morbidity and mortality in hospitalized patients. Data to guide the duration of antibiotic therapy are limited

Portraying infective endocarditis: results of multinational ID-IRI study.

Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).SCOPUS: ar.jinfo:eu-repo/semantics/publishe