Autophagy in major human diseases

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders

Mercados educacionais e a comunidade Education markets and the community

Os defensores de abordagens baseadas no mercado para a educação invocam, às vezes, a necessidade de "empoderamento" (empowerment) das comunidades nas tomadas de decisão educacionais para justificar a reforma dos sistemas educacionais públicos convencionais. Com base em exemplos da Austrália, da Inglaterra e do País de Gales, da Nova Zelândia e dos eua, este artigo explora as maneiras complexas e contraditórias como as políticas educacionais contemporâneas usam o conceito de envolvimento das comunidades. Ele demonstra mais ainda que o papel e o impacto do envolvimento das comunidades nas escolas nada têm de simples. O artigo conclui que, se o envolvimento das comunidades quer ter efeitos progressistas, ele deve ser articulado com uma política de educação democrática mais ampla.<br>The proponents of market-based approaches to education have sometimes invoked the need for community empowerment in educational decision-making to justify the reform of conventional state educational systems. Drawing upon examples from Australia, England and Wales, New Zealand and the usa, this paper explores the complex and contradictory ways in which the concept of community involvement is used in contemporary education policy. It further demonstrates that the role and impact of community involvement in schools are by no means straightforward. The paper concludes that, if community involvement is to be progressive in its effects, it will need to be articulated with a broader democratic politics of education