Lameness of Equines: Discussion of Most Common Types

When the automobile replaced the driving and riding horse as a means of transportation and the tractor and truck began to replace the draft horse, the problem of lameness became progressively less important. Now with the return of the light horse to popularity the veterinarian is again confronted with this old-time problem

Utilizing Accelerometer Telemetry Tags to Compare Red Snapper (Lutjanus campechanus) Behavior on Artificial and Natural Reefs

The Texas Parks and Wildlife Department Artificial Reef Program has deployed over 2,800 hectares of reefing area composed of petroleum platforms, steel vessels, and concrete. Artificial reefs have been shown to support many important reef fishes such as red snapper (Lutjanus campechanus), however, few studies have compared fish behavior on artificial reefs and natural habitats. We examined activity levels, behavioral patterns and habitat preferences of red snapper over natural reefs, oil platforms and submerged ships. Telemetry tags (Sonotronics model MTT) with tri-axial acceleration range, average depth, and average temperature were programmed to optimize data collection and tag life. Tags were then calibrated with captive fish to determine behavioral categories. Fifty-five wild snapper were caught and surgically implanted at depth to reduce barotrauma and predation, then monitored for one year. Overall dynamic body acceleration (ODBA) as the sum of x, y and z acceleration range was used to estimate activity levels of red snapper residing at each reef type. A variety of residency times were detected on all reef types and fish commonly moved between reefs. Acceleration and depth data indicated that time of day, depth use, lunar cycle, and season influence red snapper movement and behavior. Average ODBA was significantly higher over artificial than natural reefs (p = 0.03) during May 2016 suggesting that red snapper behave differently on artificial habitats. On-going research will determine if higher activity levels recorded on artificial reefs are due to increased feeding opportunities, spawning behavior or increased conspecific interactions

Clinical measurements versus patient-reported outcomes: analysis of the American Shoulder and Elbow Surgeons physician assessment in patients undergoing reverse total shoulder arthroplasty.

BackgroundThe American Shoulder and Elbow Surgeons (ASES) score is composed of a patient-reported portion and a physician assessment. Although the patient-reported score is frequently used to assess postoperative outcomes after shoulder arthroplasty, no previous studies have used the physician-assessment component. This study evaluated the relationship of the ASES physician-assessment measurements with patient-reported shoulder and general health outcomes.MethodsA retrospective review of a prospectively collected multicenter database was used to analyze patients who underwent primary reverse total shoulder arthroplasty (RTSA) from 2012 to 2015 with a minimum 2-year follow-up. ASES physician-assessment and patient-reported components and 12-Item Short Form Health Survey (SF-12) general health questionnaires were obtained preoperatively and 2 years postoperatively. The relationship between ASES physician measurements with ASES patient-reported outcome (PRO) scores and SF-12 Physical and Mental domain scores was assessed with Pearson correlation coefficients.ResultsIncluded were 74 patients (32 men; mean age, 69.2 years; body mass index, 29.4 kg/m2). Preoperative physician measurements and PRO scores were not significantly correlated. Postoperatively, only the ASES physician-measured active (R = 0.54, P < .01) and passive forward flexion (R = 0.53, P < .01) demonstrated moderate correlation with ASES patient scores. The remaining clinical measurements had no significant correlations with ASES patient or SF-12 scores. During the 2-year period, only improvements in active forward flexion correlated with improvements in ASES patient scores (R = 0.36, P < .01).ConclusionsLittle correlation exists between clinical measurements from the ASES physician component and PROs, including the ASES patient-reported and SF-12 general health surveys, in RTSA patients. Improvement in active forward flexion is the only clinical measurement correlated with PRO improvement at 2 years

The global distribution of Bacillus anthracis and associated anthrax risk to humans, livestock and wildlife.

Bacillus anthracis is a spore-forming, Gram-positive bacterium responsible for anthrax, an acute infection that most significantly affects grazing livestock and wild ungulates, but also poses a threat to human health. The geographic extent of B. anthracis is poorly understood, despite multi-decade research on anthrax epizootic and epidemic dynamics; many countries have limited or inadequate surveillance systems, even within known endemic regions. Here, we compile a global occurrence dataset of human, livestock and wildlife anthrax outbreaks. With these records, we use boosted regression trees to produce a map of the global distribution of B. anthracis as a proxy for anthrax risk. We estimate that 1.83 billion people (95% credible interval (CI): 0.59-4.16 billion) live within regions of anthrax risk, but most of that population faces little occupational exposure. More informatively, a global total of 63.8 million poor livestock keepers (95% CI: 17.5-168.6 million) and 1.1 billion livestock (95% CI: 0.4-2.3 billion) live within vulnerable regions. Human and livestock vulnerability are both concentrated in rural rainfed systems throughout arid and temperate land across Eurasia, Africa and North America. We conclude by mapping where anthrax risk could disrupt sensitive conservation efforts for wild ungulates that coincide with anthrax-prone landscapes

Lipidome of mammographic breast density in premenopausal women

BACKGROUND: High mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanisms underlying MBD are unclear. Lipids play important roles in cell differentiation, and perturbations in lipid metabolism are implicated in cancer development. Nevertheless, no study has applied untargeted lipidomics to profile the lipidome of MBD. Through this study, our goal is to characterize the lipidome of MBD in premenopausal women. METHODS: Premenopausal women were recruited during their annual screening mammogram at the Washington University School of Medicine in St. Louis, MO. Untargeted lipidomic profiling for 982 lipid species was performed at Metabolon (Durham, NC®), and volumetric measures of MBD (volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV)) was assessed using Volpara 1.5 (Volpara Health®). We performed multivariable linear regression models to investigate the associations of lipid species with MBD and calculated the covariate-adjusted least square mean of MBD by quartiles of lipid species. MBD measures were log RESULTS: Of the 705 premenopausal women, 72% were non-Hispanic white, and 23% were non-Hispanic black. Mean age, and BMI were 46 years and 30 kg/m CONCLUSIONS: We report novel lipid species that are associated with MBD in premenopausal women. Studies are needed to validate our results and the translational potential

NFPA Fluid Powered Vehicle Challenge 2023

This report includes the design process undergone by Team Shifty in designing a vehicle for the NFPA’s Fluid Powered Vehicle challenge. The report covers the background of the competition, research done by the team, engineering specifications for the design, preliminary and final designs, the manufacturing plan and process, project management details, and several recommendations for future teams participating in the challenge. The National Fluid Power Association, NFPA, is a trade association with the goal of connecting fluid power companies and advancing fluid power. With the goal of advancement in mind, NFPA hosts an annual Fluid Powered Vehicle Challenge (FPVC). Since before the NFPA took over this challenge, Cal Poly has produced a team to compete. Team Shifty completed research into past Cal Poly teams as well as other competing university teams to define the engineering specifications for the new vehicle and decide the design directions. The final design includes a new frame to address issues with the last teams frame, a new hydraulic circuit design and selection of new components to improve the circuits performance in the FPVC events and reduce losses, and the addition of gear shifting to the vehicle. With respect to hydraulics, a new manifold was sourced to accommodate the simplified fluid circuit, along with a larger motor to allow the vehicle to operate at higher torque. The prior team’s pneumatic system was completely replaced by a pneumatic front gear shifting system. The electronics implemented was the same system as the previous year, including an STM microcontroller, Nextion touch screen display, and Hydraforce valve operator with only two solenoid valves. Working together, these components allowed the rider to toggle between three unique drive modes, including: direct, regen, and sprint. To produce a functional vehicle, research and planning was put into manufacturing and assembly processes as detailed in the manufacturing plan. The final product failed to perform as proposed in Team Shifty’s Scope of Work, as the vehicle’s rear chain consistently fell off during operation at the competition. This resulted in the vehicle not placing during a few of the challenges, including the Sprint and Endurance races. The cause of this failure was a function of the frame flexing under dynamic loading due to insufficient torsional stiffness, as well as the rear chain being too small to handle the large output torque of the upsized rear motor

Quantifying Inter- and Intra-Population Niche Variability Using Hierarchical Bayesian Stable Isotope Mixing Models

Variability in resource use defines the width of a trophic niche occupied by a population. Intra-population variability in resource use may occur across hierarchical levels of population structure from individuals to subpopulations. Understanding how levels of population organization contribute to population niche width is critical to ecology and evolution. Here we describe a hierarchical stable isotope mixing model that can simultaneously estimate both the prey composition of a consumer diet and the diet variability among individuals and across levels of population organization. By explicitly estimating variance components for multiple scales, the model can deconstruct the niche width of a consumer population into relevant levels of population structure. We apply this new approach to stable isotope data from a population of gray wolves from coastal British Columbia, and show support for extensive intra-population niche variability among individuals, social groups, and geographically isolated subpopulations. The analytic method we describe improves mixing models by accounting for diet variability, and improves isotope niche width analysis by quantitatively assessing the contribution of levels of organization to the niche width of a population