176 research outputs found
The Implications of Interactions for Science and Philosophy
Reductionism has dominated science and philosophy for centuries. Complexity
has recently shown that interactions---which reductionism neglects---are
relevant for understanding phenomena. When interactions are considered,
reductionism becomes limited in several aspects. In this paper, I argue that
interactions imply non-reductionism, non-materialism, non-predictability,
non-Platonism, and non-nihilism. As alternatives to each of these, holism,
informism, adaptation, contextuality, and meaningfulness are put forward,
respectively. A worldview that includes interactions not only describes better
our world, but can help to solve many open scientific, philosophical, and
social problems caused by implications of reductionism.Comment: 12 pages, 2 figure
Spatially organizing future genders: an artistic intervention in the creation of a hir-toilet
Toilets, a neglected facility in the study of human relations at work and beyond, have become increasingly important in discussions about future experiences of gender diversity. To further investigate the spatial production of gender and its potential expressions, we transformed a unisex single-occupancy toilet at Uppsala University into an all-gender or ‘hir-toilet’.1 With the aim to disrupt and expose the dominant spatial organization of the two binary genders, we inaugurated the hir-toilet with the help of a performance artist. We describe and analyse internal and external responses thereto, using Lefebvre’s work on dialectics and space. Focusing on how space is variously lived, conceived and perceived, our analysis questions the very rationale of gender categorizations. The results contribute to a renewed critique of binary thinking in the organization of workplaces by extending our understanding of how space and human relations mutually constitute each other
Magnetolocalization in disordered quantum wires
The magnetic field dependent localization in a disordered quantum wire is
considered nonperturbatively.
An increase of an averaged localization length with the magnetic field is
found, saturating at twice its value without magnetic field.
The crossover behavior is shown to be governed both in the weak and strong
localization regime by the magnetic diffusion length L_B. This function is
derived analytically in closed form as a function of the ratio of the mean free
path l, the wire thickness W, and the magnetic length l_B for a two-dimensional
wire with specular boundary conditions, as well as for a parabolic wire. The
applicability of the analytical formulas to resistance measurements in the
strong localization regime is discussed. A comparison with recent experimental
results on magnetolocalization is included.Comment: 22 pages, RevTe
Strong localization of electrons in quasi-one-dimensional conductors
We report on the experimental study of electron transport in sub-micron-wide
''wires'' fabricated from Si -doped GaAs. These quasi-one-dimensional
(Q1D) conductors demonstrate the crossover from weak to strong localization
with decreasing the temperature. On the insulating side of the crossover, the
resistance has been measured as a function of temperature, magnetic field, and
applied voltage for different values of the electron concentration, which was
varied by applying the gate voltage. The activation temperature dependence of
the resistance has been observed with the activation energy close to the mean
energy spacing of electron states within the localization domain. The study of
non-linearity of the current-voltage characteristics provides information on
the distance between the critical hops which govern the resistance of Q1D
conductors in the strong localization (SL) regime. We observe the exponentially
strong negative magnetoresistance; this orbital magnetoresistance is due to the
universal magnetic-field dependence of the localization length in Q1D
conductors. The method of measuring of the single-particle density of states
(DoS) in the SL regime has been suggested. Our data indicate that there is a
minimum of DoS at the Fermi level due to the long-range Coulomb interaction.Comment: 12 pages, 11 figures; the final version to appear in Phys. Rev.
Disturbance spreading in incommensurate and quasiperiodic systems
The propagation of an initially localized excitation in one dimensional
incommensurate, quasiperiodic and random systems is investigated numerically.
It is discovered that the time evolution of variances of atom
displacements depends on the initial condition. For the initial condition with
nonzero momentum, goes as with and 0 for
incommensurate Frenkel-Kontorova (FK) model at below and above
respectively; and for uniform, quasiperiodic and random chains. It
is also found that with the exponent of distribution
function of frequency at zero frequency, i.e., (as ). For the initial condition with zero
momentum, for all systems studied. The underlying physical meaning
of this diffusive behavior is discussed.Comment: 8 Revtex Pages, 5 PS figures included, to appear in Phys. Rev. B
April 200
Adult granulosa cell tumor associated with endometrial carcinoma: a case report
<p>Abstract</p> <p>Introduction</p> <p>If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, estrogen-dependent endometrial cancers are rarely found, and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early.</p> <p>Case presentation</p> <p>We report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium (International Federation of Obstetricians and Gynecologists stage 1B). She had a good post-operative recovery and was discharged 10 days after treatment.</p> <p>Conclusion</p> <p>The association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis.</p
On the Electron-Electron Interactions in Two Dimensions
In this paper, we analyze several experiments that address the effects of
electron-electron interactions in 2D electron (hole) systems in the regime of
low carrier density. The interaction effects result in renormalization of the
effective spin susceptibility, effective mass, and g*-factor. We found a good
agreement among the data obtained for different 2D electron systems by several
experimental teams using different measuring techniques. We conclude that the
renormalization is not strongly affected by the material or sample-dependent
parameters such as the potential well width, disorder (the carrier mobility),
and the bare (band) mass. We demonstrate that the apparent disagreement between
the reported results on various 2D electron systems originates mainly from
different interpretations of similar "raw" data. Several important issues
should be taken into account in the data processing, among them the dependences
of the effective mass and spin susceptibility on the in-plane field, and the
temperature dependence of the Dingle temperature. The remaining disagreement
between the data for various 2D electron systems, on one hand, and the 2D hole
system in GaAs, on the other hand, may indicate more complex character of
electron-electron interactions in the latter system.Comment: Added refs; corrected typos. 19 pages, 7 figures. To be published in:
Chapter 19, Proceedings of the EURESCO conference "Fundamental Problems of
Mesoscopic Physics ", Granada, 200
Multidisciplinary applications of complex networks modeling, simulation, visualization, and analysis
Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial
BACKGROUND: Low-grade serous carcinoma of the ovary or peritoneum is characterised by MAPK pathway aberrations and its reduced sensitivity to chemotherapy relative to high-grade serous carcinoma. We compared the MEK inhibitor trametinib to physician's choice standard of care in patients with recurrent low-grade serous carcinoma. METHODS: This international, randomised, open-label, multicentre, phase 2/3 trial was done at 84 hospitals in the USA and UK. Eligible patients were aged 18 years or older with recurrent low-grade serous carcinoma and measurable disease, as defined by Response Evaluation Criteria In Solid Tumors version 1.1, had received at least one platinum-based regimen, but not all five standard-of-care drugs, and had received an unlimited number of previous regimens. Patients with serous borderline tumours or tumours containing low-grade serous and high-grade serous carcinoma were excluded. Eligible patients were randomly assigned (1:1) to receive either oral trametinib 2 mg once daily (trametinib group) or one of five standard-of-care treatment options (standard-of-care group): intravenous paclitaxel 80 mg/m2 by body surface area on days 1, 8, and 15 of every 28-day cycle; intravenous pegylated liposomal doxorubicin 40-50 mg/m2 by body surface area once every 4 weeks; intravenous topotecan 4 mg/m2 by body surface area on days 1, 8, and 15 of every 28-day cycle; oral letrozole 2·5 mg once daily; or oral tamoxifen 20 mg twice daily. Randomisation was stratified by geographical region (USA or UK), number of previous regimens (1, 2, or ≥3), performance status (0 or 1), and planned standard-of-care regimen. The primary endpoint was investigator-assessed progression-free survival while receiving randomised therapy, as assessed by imaging at baseline, once every 8 weeks for 15 months, and then once every 3 months thereafter, in the intention-to-treat population. Safety was assessed in patients who received at least one dose of study therapy. This trial is registered with ClinicalTrials.gov, NCT02101788, and is active but not recruiting. FINDINGS: Between Feb 27, 2014, and April 10, 2018, 260 patients were enrolled and randomly assigned to the trametinib group (n=130) or the standard-of-care group (n=130). At the primary analysis, there were 217 progression-free survival events (101 [78%] in the trametinib group and 116 [89%] in the standard-of-care group). Median progression-free survival in the trametinib group was 13·0 months (95% CI 9·9-15·0) compared with 7·2 months (5·6-9·9) in the standard-of-care group (hazard ratio 0·48 [95% CI 0·36-0·64]; p<0·0001). The most frequent grade 3 or 4 adverse events in the trametinib group were skin rash (17 [13%] of 128), anaemia (16 [13%]), hypertension (15 [12%]), diarrhoea (13 [10%]), nausea (12 [9%]), and fatigue (ten [8%]). The most frequent grade 3 or 4 adverse events in the standard-of-care group were abdominal pain (22 [17%]), nausea (14 [11%]), anaemia (12 [10%]), and vomiting (ten [8%]). There were no treatment-related deaths. INTERPRETATION: Trametinib represents a new standard-of-care option for patients with recurrent low-grade serous carcinoma. FUNDING: NRG Oncology, Cancer Research UK, Target Ovarian Cancer, and Novartis
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