Functional characteristics of intracellular processes in CD4+ cells following PHA activation in RA patients before and during therapy.

<p>Data are expressed as median [interquartile range].</p>A<p>versus control P<0.05;</p>B<p>versus baseline P<0.05.</p><p>AUC = area under the curve; Max = maximum value; t_max = time to reach maximum value; rpv = relative parameter value.</p><p>GCS = glucocorticosteroid; MTX = methotrexate; LF = leflunomide; IFX = infliximab; ETA = etanercept; ADA = adalimumab; RA = rheumatoid arthritis.</p

Schematic demonstration of kinetic parameters of the investigated intracellular processes during the activation of T-lymphocytes.

<p>Max = Maximum value, tmax = Time to reach maximum.</p

Clinical data and patient characteristics.

<p>GCS = glucocorticosteroid; MTX = methotrexate; LF = leflunomide; IFX = infliximab; ETA = etanercept; ADA = adalimumab; RA = rheumatoid arthritis; Anti-MCV = anti-mutated citrullinated vimentin; DAS-28 = disease activity score in 28 joints; CRP = c-reactive protein; ESR = erythrocyte sedimentation rate.</p><p>Data are expressed as median [interquartile range].</p

Area under the curve values of cytoplasmic calcium and reactive oxigen species in CD4+ cells.

<p>A-versus controls P<0.05; B-versus baseline P<0.05. AUC = area under the curve; RA = rheumatoid arthritis; IFX = infliximab; ETA = etanercept; ADA = adalimumab.</p