THE CONTRIBUTION OF THE BIOMAGNETOMETER SQUID TO THE INVESTIGATION OF THE HEMODYNAMICS OF THE UMBILICAL CORD

THE UMBILICAL CORD CONSTITUΤES AN IMPORTANT FACTOR FOR THE FETAL GROWTH BECAUSE IT IS THE BLOOD CARRIER TO THE FETUS. THE REDUCTION OF THE AMOUNT OF THE TRANSFERRED BLOOD TO THE FETUS ALWAYS LEADS TO DANGEROUS, FOR THE BABY, SITUATIONS. IN THE LAST DECADE THE DOPPLER METHOD HAS BEEN APPLIED WHICH GIVES ADEQUATE INFORMATION ABOUT THE CONDITION OF THE FETUS. BECAUSE IT IS STILL UNKNOWN IF THIS METHOD IS CONSIDERED NON-INVASIVE FOR THE FETUS, WE EXAMINED THE CHANGES IN THE HEMODYNAMICS OF THE UMBILICAL CORD WITH THE USE OF THE BIOMAGNETOMETER SQUID. THE BIOMAGNETIC ACTIVITY EMITTED FROM THE CHANGES OF THE BLOOD FLOW TO THE UMBILICAL VESSELS WAS EXAMINED IN 69 PREGNANT WOMEN AGED BETWEEN 16 AND38 YEARS. THEY WERE EITHER PRIMIPAROUS OR MULTIPAROUS AND THEIR PREGNANCY AGEWAS BETWEEN 36 AND 41 WEEKS. OUR FINDINGS WAS CORRELATED WITH OTHERS CONTROL PARAMETERS OF THE FETOPLACENTAL UNIT.Ο ΟΜΦΑΛΙΟΣ ΛΩΡΟΣ ΑΠΟΤΕΛΕΙ ΕΝΑ ΣΠΟΥΔΑΙΟ ΠΑΡΑΓΟΝΤΑ ΓΙΑ ΤΗΝ ΑΝΑΠΤΥΞΗ ΤΟΥ ΕΜΒΡΥΟΥ ΚΑΘ'ΟΣΟΝ ΑΠΟΤΕΛΕΙ ΤΟΝ ΜΕΤΑΦΟΡΕΑ ΑΙΜΑΤΟΣ ΠΡΟΣ ΑΥΤΟ. Η ΕΛΑΤΤΩΣΗ ΤΟΥ ΠΡΟΣΑΓΟΜΕΝΟΥ ΠΡΟΣ ΤΟ ΕΜΒΡΥΟ ΑΙΜΑΤΟΣ ΟΔΗΓΕΙ ΠΑΝΤΟΤΕ ΣΕ ΕΠΙΚΙΝΔΥΝΕΣ ΓΙ'ΑΥΤΟ ΚΑΤΑΣΤΑΣΕΙΣ. ΤΗΝ ΤΕΛΕΥΤΑΙΑ ΔΕΚΑΕΤΙΑ ΕΦΑΡΜΟΣΤΗΚΕ ΓΙΑ ΤΟ ΣΚΟΠΟ ΤΗΣ ΕΚΤΙΜΗΣΗΣ ΤΗΣ ΟΜΦΑΛΙΚΗΣ ΚΥΚΛΟΦΟΡΙΑΣ Η ΜΕΘΟΔΟΣ DOPPLER, Η ΟΠΟΙΑ ΔΙΝΕΙ ΑΡΚΕΤΕΣ ΠΛΗΡΟΦΟΡΙΕΣ. ΕΠΕΙΔΗ ΕΙΝΑΙ ΑΚΟΜΗ ΑΓΝΩΣΤΟ ΑΝ Η ΜΕΘΟΔΟΣ ΑΥΤΗ ΕΙΝΑΙ ΜΗ ΕΠΕΜΒΑΤΙΚΗ ΓΙΑ ΤΟ ΕΜΒΡΥΟ, ΕΞΕΤΑΣΤΗΚΑΝ ΟΙ ΑΛΛΑΓΕΣ ΣΤΗΝ ΑΙΜΟΔΥΝΑΜΙΚΗ ΤΟΥ ΟΜΦΑΛΙΟΥ ΛΩΡΟΥ ΜΕ ΧΡΗΣΗ ΤΟΥ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟΥ SQUID. Η ΒΙΟΜΑΓΝΗΤΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ Η ΟΠΟΙΑ ΕΚΠΕΜΠΕΤΑΙ ΑΠΟ ΤΟ ΚΥΚΛΟΦΟΡΟΥΜΕΝΟ ΣΤΑ ΟΜΦΑΛΙΚΑ ΑΓΓΕΙΑ ΑΙΜΑ, ΕΞΕΤΑΣΤΗΚΕ ΣΕ 69 ΕΓΚΥΕΣ ΗΛΙΚΙΑΣ ΜΕΤΑΞΥ 16 ΚΑΙ 38 ΕΤΩΝ, ΠΡΩΤΟΤΟΚΕΣ ΚΑΙ ΠΟΛΥΤΟΚΕΣ ΚΑΙ ΤΩΝ ΟΠΟΙΩΝ Η ΗΛΙΚΙΑ ΚΥΗΣΗΣ ΚΥΜΑΙΝΟΝΤΑΝ ΑΠΟ36-41 ΕΒΔΟΜΑΔΕΣ. ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΣΥΣΧΕΤΙΣΘΗΚΑΝ ΜΕ ΑΛΛΕΣ ΠΑΡΑΜΕΤΡΟΥΣ ΕΛΕΓΧΟΥ ΤΗΣ ΕΜΒΡΥΟΠΛΑΚΟΥΝΤΙΑΚΗΣ ΜΟΝΑΔΑΣ. ΣΕ 33 ΦΥΣΙΟΛΟΓΙΚΕΣ ΕΓΚΥΜΟΣΥΝΕΣ Τ'ΑΠΟΤΕΛΕΣΜΑΤΑΑΠΟ ΤΟ SQUID ΧΑΡΑΚΤΗΡΙΣΤΗΚΑΝ ΩΣ ΦΥΣΙΟΛΟΓΙΚΑ. ΣΕ 22 ΑΠΟ ΤΙΣ ΥΠΟΛΟΙΠΕΣ 36 ΠΑΘΟΛΟΓΙΚΕΣ ΕΓΚΥΜΟΣΥΝΕΣ ΥΠΗΡΞΕ ΑΠΟΛΥΤΗ ΣΥΣΧΕΤΙΣΗ (Ρ<10Ε-6) ΜΕΤΑΞΥ ΠΑΘΟΛΟΓΙΚΩΝ ΕΥΡΗΜΑΤΩΝ ΑΠΟ ΤΗΝ ΕΚΠΕΜΠΟΜΕΝΗ ΒΙΟΜΑΓΝΗΤΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ ΚΑΙ ΤΩΝ ΠΑΡΑΜΕΤΡΩΝ ΕΛΕΓΧΟΥ. ΑΠΟ ΤΑ ΑΝΩΤΕΡΩ ΔΕΙΧΝΕΤΑΙ Η ΣΥΜΒΟΛΗ ΤΟΥ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟΥ ΣΤΗΝ ΕΓΚΑΙΡΗ ΔΙΑΓΝΩΣΗ ΤΩΝ ΑΙΜΟΔΥΝΑΜΙΚΩΝ ΔΙΑΤΑΡΑΧΩΝ ΤΟΥ ΟΜΦΑΛΙΟΥ ΛΩΡΟΥ

Endometrial Stromal Hyperplasia: An Underrecognized Condition

Hyperplasia of the endometrial stroma is a poorly recognized lesion, lacking widespread recognition with most, if not all, such cases sequestrated in the literature as endometrial stromal nodules or low-grade endometrial stromal sarcomas. In this paper, we describe three examples of “endometrial stromal hyperplasia” which have a remarkable morphological similarity with the normally proliferating endometrial stroma and the endometrial stromal neoplasms, but which also possess subtle, but sufficient, differences to justify their taxonomic separation

Altered Intrahepatic Hematopoiesis in Neonates from Women with Pregnancy Induced Hypertension/Pre-Eclampsia

Summary: Aim: To detect whether preeclampsia influences neonatal intrahepatic hematopoiesis, given that an activation of fetal neutrophils and monocytes during the course of this disorder occurs. Experimental design: We examined liver samples from 10 neonates of hypertensive/preeclamptic women at 27 to 28 weeks of gestation delivered by a cessarian section. All neonates were placed in incubators but they all died within 24 hours due to immaturity. The control group comprised 10 fetuses of the same gestational age, after voluntary abortion due to a neural defect. Specific antibodies against CD34, glycophorin C, hemoglobins A and F, myeloperoxidase, CD61, CD68, terminal desoxynucleotidyl transferase and the pax-5/B-cell specific activator protein, were used in each sample. Results: Neonates from hypertensive/preeclamptic women, in comparison with controls, showed: a statistically significant reduction of erythropoiesis by 25% (p=0.015); a statistically significant increase of granulopoiesis (p=0.019); a statistically significant increase in the expression of CD68 positive cells of the monocytic lineage (p=0.017); a statistically significant increase in the expression of CD34 progenitor/stem positive cells (p=0.021). No statistically significant differences were observed in both examined groups, concerning megakaryopoiesis and B lymphopoiesis. Conclusions: Preeclampsia of pregnancy has an impact on neonatal intrahepatic hematopoiesis by increasing granulopoiesis, reducing erythropoiesis and triggering endothelial and stem cell activation. We suggest that these findings reflect a state of persistent inflammation and a loss of red blood cell production possibly contributing to the neonatal morbidity related to this disorder