Distribution of serum biomarker levels in patients with normal (blue, < 200 mg/kg) and increased (red, > 200 mg/kg) fecal calprotectin levels, shown in boxplots.

<p>(A) Serum IL-6 levels (pg/mL). (B) Serum IL-17A levels (pg/mL). (C) Serum TNF-β levels (pg/mL). (D) Serum SAA levels (pg/mL). *<i>P</i> < 0.05; **<i>P</i> < 0.01.</p

Correlations of fecal calprotectin levels (mg/kg) with serum levels of all detected molecules (pg/mL) in patients with Crohn’s disease.

<p>Correlations of fecal calprotectin levels (mg/kg) with serum levels of all detected molecules (pg/mL) in patients with Crohn’s disease.</p

Median (IQR) of serum levels of all detected molecules (pg/mL) in Crohn’s disease patients with ‘normal’ (< 200 mg/kg) and increased (> 200 mg/kg) fecal calprotectin levels.

<p>Median (IQR) of serum levels of all detected molecules (pg/mL) in Crohn’s disease patients with ‘normal’ (< 200 mg/kg) and increased (> 200 mg/kg) fecal calprotectin levels.</p

Distribution of serum biomarker levels in patients with normal (blue, < 200 mg/kg) and increased (red, > 200 mg/kg) fecal calprotectin levels, shown in boxplots.

<p>(A) Serum CRP levels (pg/mL). (B) Serum IFN-γ levels (pg/mL). *<i>P</i> < 0.05; **<i>P</i> < 0.01.</p

Study population characteristics (<i>n</i> = 39) of Crohn’s disease patients with ‘normal’ (< 200 mg/kg) and increased (> 200 mg/kg) fecal calprotectin levels.

<p>Study population characteristics (<i>n</i> = 39) of Crohn’s disease patients with ‘normal’ (< 200 mg/kg) and increased (> 200 mg/kg) fecal calprotectin levels.</p

Demographics of included subjects (healthy volunteers).

<p>Demographics of included subjects (healthy volunteers).</p

Study schedule, activities are marked with an X (T0 is 8 a.m.).

<p>Study schedule, activities are marked with an X (T0 is 8 a.m.).</p

Mean (gastrointestinal residence and transit times determined with the IntelliCap system.

<p>Data are presented mean and standard deviation of 13 evaluable subjects (for CTT and WGTT n = 9).</p

Colon arrival time based on pH (-) corresponds with release of ¹³C (♦) (subject 14).

<p>See also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129076#pone.0129076.g004" target="_blank">Fig 4</a> for the first 10 hours.</p

Difference (delta T) between lag-time (based on isotope signal) and CAT (based on pH) for each subject (n = 12).

<p>Difference (delta T) between lag-time (based on isotope signal) and CAT (based on pH) for each subject (n = 12).</p