A) Number of fragments 〈〉 found the selected target sequence Influenza (NCBI∶CY000076) that are correctly identified as a function of probe length

The average standard error is 0.23% and was consistent across all the data points. b) The average number of probes

Reassembled contigs longer than 200 nt in the 81 090 nt of the BRCA1 gene

<p><b>Copyright information:</b></p><p>Taken from "An analysis of the feasibility of short read sequencing"</p><p>Nucleic Acids Research 2005;33(19):e171-e171.</p><p>Published online 7 Nov 2005</p><p>PMCID:PMC1278949.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> <p>http://dx.crossref.org/10.1093%2Fnar%2Fgni170</p> Reassembly was simulated from 25, 50 and 100 nt reads covering the whole of chromosome 17. Reassembled contigs are shown in alternating black and grey. Contigs maybe next to each other, or overlapping slightly without an unambiguous overlap existing between the contigs

Percentage of unique sub-sequences (U) for varying read length (l), the solid line shows uniqueness in the whole human genome, the dashed line shows uniqueness in human chromosome 1

<p><b>Copyright information:</b></p><p>Taken from "An analysis of the feasibility of short read sequencing"</p><p>Nucleic Acids Research 2005;33(19):e171-e171.</p><p>Published online 7 Nov 2005</p><p>PMCID:PMC1278949.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> (a) Percentage of unique sub-sequences (U) for varying read length (l), the solid line shows uniqueness in the whole human genome, the dashed line shows uniqueness in human chromosome 1. (b) Percentage of human chromosome 1 covered by contigs greater than a threshold length as a function of read length. The horizontal axis starts at 18 nt, due to the limitations of reassembly below this length

The figure shows the optimal mRNA secondary structure of the RET haplotypes.

<p>A) Total mRNA secondary structure of the <i>RET</i> wild-type (WT) haplotype. B) Part of mRNA secondary structure of the <i>RET</i> WT haplotype. C) Part of mRNA secondary structure of the <i>RET</i> S836S haplotype (</p><p>T<u>T</u>CGT</p>). D) Part of mRNA secondary structure of the <i>RET</i> 3’UTR haplotype (<p><u>GT</u>C<u>AC</u></p>). Haplotypes generated by RNAfold program (Vienna Package).<p></p

Kaplan–Meier estimates the proportion of sporadic MTC patients with lymph node (A; n = 131; P = 0.011) or distant metastasis (B; n = 116; P<0.001).

<p>The log rank test was used to compare curves.</p

<i>RET</i> minor allele frequency polymorphisms in medullary thyroid carcinoma patients.

<p><i>RET</i> minor allele frequency polymorphisms in medullary thyroid carcinoma patients.</p

Haplotypes inferred by the Phase Program.

<p>Haplotypes inferred by the Phase Program.</p

The clinical and oncological features of medullary thyroid carcinoma patients.

<p>The clinical and oncological features of medullary thyroid carcinoma patients.</p

The minimal free energy (MFE, kcal/mol) and number of double helices (<i>N</i>_<i>DH</i>) were available in both, optimal and suboptimal structures.

<p>For suboptimal structures MFE and NDH are averages over 2900 samples. The variant fragment carrying the S836S and 3’UTR variants (</p><p><u>GT</u>C<u>AC</u></p> haplotype) presented greater <i>N</i>_<i>DH</i> (B,D) and lower levels of MFE (A,C) when compared to wild-type haplotype (WT, TCCGT), this fact happens in both, optimal and suboptimal structures. *These analysis included only synonymous polymorphisms.<p></p

Immunostaining of the RET proto-oncogene in GTCAC haplotype carriers & non-carriers.

<p>A) Two representative slices of RET Immunostaining in a sample carrier S836S/3’UTR (</p><p><u>GT</u>C<u>AC</u></p> haplotype) (left) and non-carrier of this haplotype (right). B) Intensity of RET Immunostaining in samples with or without S836S/3’UTR (<p><u>GT</u>C<u>AC</u></p> haplotype), P = 0.054.<p></p